CardioVascular and Interventional Radiology

, Volume 34, Issue 1, pp 132–138 | Cite as

Irreversible Electroporation of Renal Cell Carcinoma: A First-in-Man Phase I Clinical Study

  • Maciej Pech
  • Andreas Janitzky
  • Johann Jacob Wendler
  • Christof Strang
  • Simon Blaschke
  • Oliver Dudeck
  • Jens Ricke
  • Uwe-Bernd Liehr
Clinical Investigation

Abstract

Purpose

Irreversible electroporation (IRE) is a newly developed nonthermal tissue-ablation technique in which high-voltage electrical pulses of microsecond duration are applied to induce irreversible permeabilisation of the cell membrane, presumably through nanoscale defects in the lipid bilayer, leading to apoptosis. The purpose of this study was to assess the feasibility and safety of ablating renal cell carcinoma (RCC) tissue by IRE.

Methods

Six patients scheduled for curative resection of RCC were included. IRE was performed during anaesthesia immediately before the resection with electrographic synchronisation. Central haemodynamics were recorded before and 5 min after electroporation. Five-channel electrocardiography (ECG) was used for detailed analysis of ST waveforms. Blood sampling and 12-lead ECG were performed before, during, and at scheduled intervals after the intervention.

Results

Analysis of ST waveforms and axis deviations showed no relevant changes during the entire study period. No changes in central haemodynamics were seen 5 min after IRE. Similarly, haematological, serum biochemical, and ECG variables showed no relevant differences during the investigation period. No changes in cardiac function after IRE therapy were found. One case of supraventricular extrasystole was encountered. Initial histopathologic examination showed no immediate adverse effects of IRE (observation of delayed effects will require a different study design).

Conclusion

IRE seems to offer a feasible and safe technique by which to treat patients with kidney tumours and could offer some potential advantages over current thermal ablative techniques.

Keywords

Irreversible electroporation Ablation Renal carcinoma Interventional radiology 

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2010

Authors and Affiliations

  • Maciej Pech
    • 1
  • Andreas Janitzky
    • 2
  • Johann Jacob Wendler
    • 2
  • Christof Strang
    • 3
  • Simon Blaschke
    • 2
  • Oliver Dudeck
    • 1
  • Jens Ricke
    • 1
  • Uwe-Bernd Liehr
    • 2
  1. 1.Department of Radiology and Nuclear MedicineUniversity of MagdeburgMagdeburgGermany
  2. 2.Department of UrologyUniversity of MagdeburgMagdeburgGermany
  3. 3.Department of Anaesthesiology and Intensive Care MedicineUniversity of MagdeburgMagdeburgGermany

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