Skip to main content

Advertisement

Log in

Does Size Really Matter? Analysis of the Effect of Large Fibroids and Uterine Volumes on Complication Rates of Uterine Artery Embolisation

  • Clinical Investigation
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

The purpose of this study was to determine whether there is a correlation between large uterine fibroid diameter, uterine volume, number of vials of embolic agent used and risk of complications from uterine artery embolisation (UAE). This was a prospective study involving 121 patients undergoing UAE embolisation for symptomatic uterine fibroids at a single institution. Patients were grouped according to diameter of largest fibroid and uterine volume. Results were also stratified according to the number of vials of embolic agent used and rate of complications. No statistical difference in complication rate was demonstrated between the two groups according to diameter of the largest fibroid (large fibroids were classified as ≥10 cm; Fisher’s exact test P = 1.00), and no statistical difference in complication rate was demonstrated according to uterine volume (large uterine volume was defined as ≥750 cm3; Fisher’s exact test P = 0.70). 84 of the 121 patients had documentation of the number of vials used during the procedure. Patients were divided into two groups, with ≥4 used defined as a large number of embolic agent. There was no statistical difference between these two groups and no associated increased risk of developing complications. This study showed no increased incidence of complications in women with large-diameter fibroids or uterine volumes as defined. In addition, there was no evidence of increased complications according to quantity of embolic material used. Therefore, UAE should be offered to women with large fibroids and uterine volumes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Coleman P, Ayiku L, Nicholl J, Cross E (2004) National Institute for Clinical Excellence Interventional Procedures Programme: systematic review of the efficacy and safety of uterine artery embolisation in the treatment of fibroids. NICE Guidelines. http://www.nice.org.uk/nicemedia/live/11025/30602/30602.pdf

  2. Ravina JH, Herbreteau D, Ciraru-Vigneron N, Bouret JM, Houdart E, Aymard A et al (1995) Arterial embolisation to treat uterine myomata. Lancet 346:671–672

    Article  CAS  PubMed  Google Scholar 

  3. Pelage JP, Dref OL, Soyer P et al (2000) Fibroid-related menorrhagia: treatment with superselective embolisation for symptomatic of the uterine arteries and midterm follow-up. Radiology 215:428–431

    CAS  PubMed  Google Scholar 

  4. Worthington-Kirsch RL, Berkowiz RP, Hutchins FL (1998) Uterine artery embolisation for the management of leiomyomas: quality-of-life assessment and clinical response. Radiology 208:625–629

    CAS  PubMed  Google Scholar 

  5. Goodwin SC, Vedantham S, McLucas B, Forno AE, Perrella R (1997) Preliminary experience with uterine artery embolisation for uterine fibroids. J Vasc Interv Radiol 8:517–526

    Article  CAS  PubMed  Google Scholar 

  6. Vashisht A, Studd J, Carey A et al (1999) Fatal septicaemia after fibroid embolisation. Lancet 354:307–308

    Article  CAS  PubMed  Google Scholar 

  7. Volkers NA, Hehenkamp WJ, Birnie E et al (2006) Uterine artery embolisation in the treatment of symptomatic uterine fibroid tumours (EMMY trial): periprocedural results and complications. J Vasc Interv Radiol 17:471–480

    Article  PubMed  Google Scholar 

  8. Spies JB, Ascher SA, Roth AR, Kim J, Levy EB, Gomez-Jorge J (2001) Uterine artery embolisation for leiomyomata. Obstet Gynaecol 98:29–34

    Article  CAS  Google Scholar 

  9. Katsumori T, Nakajima K, Mihara T (2003) Is a large fibroid a high risk factor for uterine artery embolisation? AJR Am J Roentgenol 181:1309–1314

    PubMed  Google Scholar 

  10. Firouznia K, Ghanaati H, Sanaati M, Jalali A (2008) Uterine artery embolization in 101 cases of uterine fibroids: do size, location and number of fibroids affect therapeutic success and complications? Cardiovasc Intervent Radiol 31:521–526

    Article  PubMed  Google Scholar 

  11. The British Society of Intervention Radiology (2009) UK Uterine Artery Embolisation for Fibroids Registry 2003–2008. Available at: http://www.bsir.org/content/BSIRPage.aspx?pageid=98. Accessed August 2008

  12. Peddada SD, Laughlin SK, Miner K, Guyon JP (2008) Growth of uterine leiomyomata among pre-menopausal black and white women. Proc Natl Acad Sci USA 105:19887–19892

    Article  CAS  PubMed  Google Scholar 

  13. Prollius A, de Vries C, Logenberg E, du Plessis A, Nel M, Wessels PH (2004) Uterine artery embolisation for symptomatic fibroids: the effect of the large uterus on outcome. Br J Obstet Gynaecol 111:239–242

    CAS  Google Scholar 

  14. Bratby MJ, Belli A-M (2008) Radiological treatment of symptomatic uterine fibroids. Best Pract Res Clin Obstet Gynaecol 22:717–734

    Article  CAS  PubMed  Google Scholar 

  15. Goodwin SC, Bonilla SM, Sacks D, Reed RA, Spies JB et al (2003) Reporting standards for uterine artery embolisation for the treatment of uterine leiomyomata. J Vacs Interv Radiol 14:S467–476

    Google Scholar 

  16. Walker WJ, Watson GM (2002) Uterine artery embolisation for the treatment of symptomatic fibroids in 114 women: reduction in size of fibroids and women’s views of the success of the treatment. Br J Obstet Gynaecol 109:129–135

    Google Scholar 

  17. Goodwin SC, McLucas B, Lee M et al (1999) Uterine artery embolisation for the treatment of uterine leiomyoma midterm results. J Vasc Interv Radiol 10:1159–1165

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. A. Parthipun.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parthipun, A.A., Taylor, J., Manyonda, I. et al. Does Size Really Matter? Analysis of the Effect of Large Fibroids and Uterine Volumes on Complication Rates of Uterine Artery Embolisation. Cardiovasc Intervent Radiol 33, 955–959 (2010). https://doi.org/10.1007/s00270-010-9842-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-010-9842-x

Keywords

Navigation