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Whole-Body Magnetic Resonance Angiography at 3 Tesla Using a Hybrid Protocol in Patients with Peripheral Arterial Disease

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Abstract

The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing ≥ 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51–0.73) and 0.66 (0.58–0.78). Specificities were 0.94 (0.91–0.97) and 0.96 (0.92–0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64–0.84) and 0.70 (0.58–0.8), respectively. Specificities were 0.93 (0.88–0.96) and 0.95 (0.91–0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with κ = 0.62 (0.44–0.67) and κ = 0.70 (0.59–0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.

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Authors and Affiliations

  1. Department of Radiology, University Hospital at Herlev, Herlev Ringvej 75, 2730, Copenhagen, Denmark

    Yousef W. Nielsen, Vibeke B. Logager & Henrik S. Thomsen

  2. Department of Vascular Surgery, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark

    Jonas P. Eiberg & Torben V. Schroeder

  3. Department of Radiology, University Hospital at Gentofte, Niels Andersens Vej 65, 2900, Copenhagen, Denmark

    Sven Just

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  1. Yousef W. Nielsen
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  2. Jonas P. Eiberg
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  3. Vibeke B. Logager
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  4. Torben V. Schroeder
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  5. Sven Just
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  6. Henrik S. Thomsen
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Correspondence to Yousef W. Nielsen.

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Nielsen, Y.W., Eiberg, J.P., Logager, V.B. et al. Whole-Body Magnetic Resonance Angiography at 3 Tesla Using a Hybrid Protocol in Patients with Peripheral Arterial Disease. Cardiovasc Intervent Radiol 32, 877–886 (2009). https://doi.org/10.1007/s00270-009-9549-z

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  • DOI: https://doi.org/10.1007/s00270-009-9549-z

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