Abstract
Purpose
To evaluate the effects of transarterial administration of an integrin antagonist, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), combined with transarterial chemoembolization (TACE) to treat hepatic carcinoma in rats.
Methods
Walker-256 tumor was implanted beneath the liver capsule in 26 Wistar rats. Animal subjects were assigned to groups based on which treatment was injected into the hepatic artery: group A, GRGDSP + TACE; group B, TACE alone; and group C, normal saline. Magnetic resonance imaging (MRI), tumor pathology, and immunohistochemistry were performed to assess each treatment.
Results
The ratios of the post-treatment to pretreatment tumor volumes (V2/V1) in groups A, B, and C were 4.42 ± 0.48, 6.98 ± 1.09, and 13.00 ± 1.68, respectively. The metastatic potential of the tumors was assessed by tumor cell nest counts, which were 5.00 ± 1.25, 6.63 ± 1.60, and 7.22 ± 1.92 in groups A, B, and C, respectively. Microvessel density (MVD) was quantified by measuring von Willebrand factor density values, which were 0.18 ± 0.02, 0.22 ± 0.02, and 0.23 ± 0.02 in groups A, B, and C, respectively.
Conclusions
Transarterial infusion of GRGDSP combined with TACE noticeably inhibited the growth of hepatic carcinoma and intrahepatic metastases in rats.
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Qian, J., Yin, J., Liang, H. et al. Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma. Cardiovasc Intervent Radiol 31, 377–382 (2008). https://doi.org/10.1007/s00270-007-9233-0
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DOI: https://doi.org/10.1007/s00270-007-9233-0