Skip to main content
SpringerLink
Log in

Trisacryl Gelatin Microspheres Versus Polyvinyl Alcohol Particles in the Preoperative Embolization of Bone Neoplasms

  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

The aim of this study was to compare the efficacy of trisacryl gelatin microspheres versus polyvinyl alcohol particles (PVA) in the preoperative embolization of bone neoplasms, on the basis of intraoperative blood loss quantified by the differences in preoperative and postoperative hematic levels of hemoglobin, hematocrit and erythrocytes count. From January 1997 to December 2002, preoperative embolization of bone tumors (either primary or secondary) was carried out in 49 patients (age range 12/78), 20 of whom were treated with trysacril gelatin microspheres (group A) and 29 with PVA particles (group B). The delay between embolization and surgery ranged from 1 to 13 days in group A and 1 to 4 days in group B. As used in international protocols, we considered hematic levels of hemoglobin, hematocrit and erythrocytes count for the measurement of intraoperative blood loss then the differences in pre- and postoperative levels were used as statistical comparative parameters. We compared the values of patients treated with embospheres (n = 10) and PVA (n = 18) alone, and patients treated with (group A = 10; group B = 11) versus patients treated without other additional embolic materials in each group (group A = 10; group B = 18). According to the Student’s t-test (p < 0.05), the difference of hematic parameters between patients treated by embospheres and PVA alone were significant; otherwise there was no significant difference between patients treated with only one embolic material (embospheres and PVA) versus those treated with other additional embolic agents in each group. The patients treated with microspheres had a minor quantification of intraoperative blood loss compared to those who received PVA particles. Furthermore, they had a minor increase of bleeding related to the delay time between embolization and surgery. The use of additional embolic material did not improve the efficacy of the procedure in either group of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.

Similar content being viewed by others

References

  1. R Capanna DA Campanacci (2001) ArticleTitleThe treatment of metastases in the appendicular skeleton J Bone Joint Surg 83-B 471–481 Occurrence Handle10.1302/0301-620X.83B4.12202

    Article  Google Scholar 

  2. A Clain (1965) ArticleTitleSecondary malignant disease of bone Br J Cancer 19 15–29 Occurrence Handle1:STN:280:CCqD1cfpsFQ%3D Occurrence Handle14284378

    CAS  PubMed  Google Scholar 

  3. E Silverberg (1986) ArticleTitleCancer statistics CA Cancer J Clin 36 9–25 Occurrence Handle1:STN:280:BiiA3c%2FpvFU%3D Occurrence Handle3113694

    CAS  PubMed  Google Scholar 

  4. C Olerud H Jr Johnsson AM Lofberg LE Lorelius L Sjostrom (1993) ArticleTitleEmbolization of spinal metastases reduces perioperative blood loss, 21 patients operated on for renal cell carcinoma Acta Ortho Scand 64 9–12 Occurrence Handle1:STN:280:ByyC1Mfls1A%3D

    CAS  Google Scholar 

  5. S Wallace M Graymeyeh LA Desantos JA Murray MM Romsdahl RB Bracken (1979) ArticleTitleArterial occlusion of pelvic bone tumors Cancer 43 322–328 Occurrence Handle1:STN:280:CSaC3critF0%3D Occurrence Handle83905

    CAS  PubMed  Google Scholar 

  6. PP Lin VB Guzel MF Moura S Wallace RS Benjamin KL Weber FA Morello ZL Gokaslan AW Yasko (2002) ArticleTitleLong-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization Cancer 95 1317–1325 Occurrence Handle10.1002/cncr.10803 Occurrence Handle12216101

    Article  PubMed  Google Scholar 

  7. Y Nagata M Mitsumori K Okajima T Mizowaki K Fujiwara K Sasai Y Nishimura M Hiraoka M Abe K Shimizu Y Kotoura (1998) ArticleTitleTranscatheter arterial embolization for malignant osseus and soft tissue sarcomas. II. Clinical results Cardiovasc Interv Radiol 21 208–213 Occurrence Handle10.1007/s002709900246 Occurrence Handle1:STN:280:DyaK1c3ovFOgug%3D%3D

    Article  CAS  Google Scholar 

  8. C Manke T Bretschneider M Lenhart M Strotzer C Neumann J Gmeinwieser S Feuerbach (2001) ArticleTitleSpinal metastasis from renal cell carcinoma: effect of preoperative particle embolization on intraoperative blood loss Am J Neuroradiol 22 997–1003 Occurrence Handle1:STN:280:DC%2BD3MzotlGqtQ%3D%3D Occurrence Handle11337348

    CAS  PubMed  Google Scholar 

  9. A Uemura H fujimoto S Yasuda I Osaka N Goto M Shinozaki H Ito (2001) ArticleTitleTranscatheter arterial embolization for bone metastases from hepatocellular carcinoma Eur Radiol 11 1457–1462 Occurrence Handle10.1007/s003300000792 Occurrence Handle1:STN:280:DC%2BD3Mvns1ahtQ%3D%3D Occurrence Handle11519558

    Article  CAS  PubMed  Google Scholar 

  10. AN Chatziioannou ME Johnson SG Pneumaticos DD Lawrence CU Carrasco (2000) ArticleTitlePreoperative embolization of bone metastases from renal cell carcinoma Eur Radiol 10 593–596 Occurrence Handle10.1007/s003300050969 Occurrence Handle1:STN:280:DC%2BD3c3lsVGmtQ%3D%3D Occurrence Handle10795540

    Article  CAS  PubMed  Google Scholar 

  11. O Elshafie S Hussein W Jeans NJY Woodhouse (2000) ArticleTitleMassive rise in thyroglobulin with adult respiratory distress syndrome after embolisation of thyroid cancer metastasis Br J Radiol 73 547–549 Occurrence Handle1:STN:280:DC%2BD3czktlWgsQ%3D%3D Occurrence Handle10884754

    CAS  PubMed  Google Scholar 

  12. R Murakami Y Baba M Furusawa T Yokoyama R Nishimura H Uozumi Y Hatanaka Y Yamashita M Takahashi (1996) ArticleTitleShort communication: the value of embolization therapy in painful osseous metastases from hepatocellular carcinomas: comparative study with radiation therapy Br J Radiol 69 1042–1044 Occurrence Handle1:STN:280:ByiC3Mnptlw%3D Occurrence Handle8958023

    CAS  PubMed  Google Scholar 

  13. JWA Smit GJ Vielvoye BM Goslings (2000) ArticleTitleEmbolization for vertebral metastases of follicular thyroid carcinoma J Clin Endocrinol Metab 85(3 989–994 Occurrence Handle10.1210/jc.85.3.989

    Article  Google Scholar 

  14. JP Wallis D Stainsby DBL McClelland (2002) ArticleTitleAudit of red cell transfusion Transfusion Medicine 12 1–9 Occurrence Handle10.1046/j.1365-3148.2002.00354.x Occurrence Handle1:STN:280:DC%2BD383jtVKltw%3D%3D

    Article  CAS  Google Scholar 

  15. N Rosencher HE Kerkkamp G Macheras LM Munuera M Menichel DM Barton S Cremers IL Abraham (2003) ArticleTitleOrthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) Study: blood management in elective and hip arthhroplasty in Europe Transfusion 43 459–469 Occurrence Handle12662278

    PubMed  Google Scholar 

  16. J Berkefeld D Scale J Kirchner T Heinrich J Kollath (1999) ArticleTitleHypervascular spinal tumors: influence of the embolization technique on perioperative hemorrhage Am J Neuroradiol 20 757–763 Occurrence Handle1:STN:280:DyaK1M3ps1Sitw%3D%3D Occurrence Handle10369341

    CAS  PubMed  Google Scholar 

  17. FE Gellad N Sadato Y Numaguchi AM Levine (1990) ArticleTitleVascular metastatic lesions of the spine: preoperative embolization Radiology 176 683–686 Occurrence Handle1:STN:280:By%2BA2Mnns1M%3D Occurrence Handle2389026

    CAS  PubMed  Google Scholar 

  18. PP Barton ER Waneck JF Karnel P Ritschl J Kramer LG Letchner (1996) ArticleTitleEmbolization of bone metastases J Vasc Interv Radiol 7 81–88 Occurrence Handle1:STN:280:BymA2s%2FgsVQ%3D Occurrence Handle8773979

    CAS  PubMed  Google Scholar 

  19. KM van Tol JM Hew PL Jager B Vermey RPF Dullaart TP Links (2000) ArticleTitleEmbolization in combination with radioiodine therapy for bone metastases from differentiated thyroid carcinoma Clin Endocrinol 52 653–659 Occurrence Handle10.1046/j.1365-2265.2000.00998.x Occurrence Handle1:STN:280:DC%2BD3c3lt12quw%3D%3D

    Article  CAS  Google Scholar 

  20. S Sun E Lang (1998) ArticleTitleBone metastases from renal cell carcinoma: preoperative embolization J Vasc Interv Radiol 9 263–269 Occurrence Handle1:STN:280:DyaK1c7pvF2kug%3D%3D Occurrence Handle9540910

    CAS  PubMed  Google Scholar 

  21. M Bendszus R Klein R Burger M Warmuthmetz E Hofman L Solymosi (2000) ArticleTitleEfficacy of trisacryl gelatin microspheres versus polyvinyl alcohol particles in the preoperative embolization of meningiomas AM J Neuroradiol 21 255–261 Occurrence Handle1:STN:280:DC%2BD3c7lvVGmsA%3D%3D Occurrence Handle10696005

    CAS  PubMed  Google Scholar 

  22. A Laurent R Beaujeux M Wassef D Rufennacht E Boschetti JJ Merland (1996) ArticleTitleTrisacryl gelatin microspheres for therapeutic embolization, I: development and in vitro evaluation AM J Neuroradiol 17 533–540 Occurrence Handle1:STN:280:ByiD3srmtVY%3D Occurrence Handle8881250

    CAS  PubMed  Google Scholar 

  23. R Beaujeux A Laurent M Wassef A Casasco YP Gobin A Aymard D Ruffennacht JJ Merland (1996) ArticleTitleTrisacryl gelatin microspheres for therapeutic embolization, II: clinical evaluation in tumors and arteriovenous malformations AM J Neuroradiol 17 541–548 Occurrence Handle1:STN:280:ByiD3srmtVc%3D Occurrence Handle8881251

    CAS  PubMed  Google Scholar 

  24. P Flandroy C Grandfills J Collignon A Thibaut N Nihant S Barbette R Jerome P Teyssie (1990) ArticleTitleD, L polyactide microspheres as an embolic agent: A preliminary study Neuroradiology 32 311–315 Occurrence Handle1:STN:280:By6D2czkvFU%3D Occurrence Handle2234391

    CAS  PubMed  Google Scholar 

  25. RG Quisling JP Mickle WB Ballinger CC Carver B Kaplan (1984) ArticleTitleHistopathologic analysis of intrarterial polyvinyl alcohol microemboli on rat cerebral cortex AM J Neuroradiol 5 101–104 Occurrence Handle1:STN:280:BiuC38vot1w%3D Occurrence Handle6421116

    CAS  PubMed  Google Scholar 

  26. SM Tadavarthy JH Moller K Amplatz (1975) ArticleTitlePolyvinyl alcohol (ivalon): a new embolic material Am J Roentgenol 125 609–615 Occurrence Handle1:STN:280:CSmD1crntVY%3D

    CAS  Google Scholar 

  27. CP Derdeyn CJ Moran DT Cross HH Dietrich RG Dacey (1995) ArticleTitlePolyvinyl alcohol particle size and suspension characteristics Am J Neuroradiol 16 1335–1343 Occurrence Handle1:STN:280:ByqH3cjltFA%3D Occurrence Handle7677036

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments:

We thank Dr. Rosangela Basile for statistical analysis.

Author information

Authors and Affiliations

  1. Division of Angiography and Interventional Radiology, University of Vienna Medical School, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    Antonio Basile, Thomas Rand, Fritz Lomoschitz, Joachim Kettenbach & Johannes Lammer

  2. Department of Orthopedic Surgery, University of Vienna Medical School, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    Cyril Toma

  3. Department of Radiology, Policlinico Monteluce, University of Perugia, via E. Dal Pozzo, Perugia, 06126, Italy

    Tommaso Lupattelli

Authors
  1. Antonio Basile
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas Rand
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fritz Lomoschitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cyril Toma
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tommaso Lupattelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Joachim Kettenbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Johannes Lammer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Basile, A., Rand, T., Lomoschitz, F. et al. Trisacryl Gelatin Microspheres Versus Polyvinyl Alcohol Particles in the Preoperative Embolization of Bone Neoplasms. CVIR 27, 495–502 (2004). https://doi.org/10.1007/s00270-003-0147-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-003-0147-1

Search

Navigation