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Micro-CT of Carotid Arteries: A Tool for Experimental Studies

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Abstract

Micro-computed tomography (micro-CT) is a high-resolution, nondestructive tool for two- and three-dimensional imaging and quantification. The ability of this technique to assess atherosclerosis of the carotid artery was evaluated in three human cadaver samples based on the original axial acquisitions, multiplanar reconstructions and volume rendering techniques. Quantitative analysis included the calculation of: (1) the original lumen perimeter, original lumen area, plaque area, residual lumen area, calcified area and gross sectional area reduction of the vascular lumen from two-dimensional slices; (2) the total tissue volume, soft tissue volume and calcified tissue volume from the three-dimensional data set. This preliminary study demonstrates the potential of micro-CT as a supplementary method for the two- and three-dimensional ex vivo evaluation of carotid atherosclerosis.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Christian Albrechts University of Kiel, Arnold-Heller-Strasse 9, D-24105, Kiel, Germany

    Andreas Mohr, Ruediger Wenke, Markus Priebe, Martin Heller & Stefan Mueller-Huelsbeck

  2. Department of Radiology, University of California San Francisco, 350 Parnassus Avenue, Suite 150, San Francisco, CA 94117-3608, USA

    Andreas Mohr, Frank W. Roemer, John A. Lynch, Ali Guermazi & Mikayel Grigorian

  3. Department of Trauma, Hand and Reconstructive Surgery, University of Hamburg, Martinistrasse 52, D-20246, Hamburg, Germany

    Christian Gatzka

Authors
  1. Andreas Mohr
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  2. Ruediger Wenke
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  3. Frank W. Roemer
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  4. John A. Lynch
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  5. Christian Gatzka
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  6. Markus Priebe
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  7. Ali Guermazi
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  8. Mikayel Grigorian
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  9. Martin Heller
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  10. Stefan Mueller-Huelsbeck
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Mohr, A., Wenke, R., Roemer, F. et al. Micro-CT of Carotid Arteries: A Tool for Experimental Studies. CVIR 27, 651–654 (2004). https://doi.org/10.1007/s00270-003-0128-4

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  • DOI: https://doi.org/10.1007/s00270-003-0128-4

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