Abstract
This study was performed to evaluate the outcome of percutaneous revascularization in “edge restenoses” developing after radioactive stent implantation in de novo and in-stent lesions. Twenty-one consecutive patients undergoing target lesion revascularization (TLR) at any follow-up after phosphorus-32 radioactive stent implantation were included in this study. We assessed the incidence of death, myocardial infarction, repeated TLR and recurrent angina over the following 18 months. After 6 months, TLR rate was 28.6%, and no stent thromboses, deaths or Q-wave myocardial infarctions occurred. Among the patients with TLR there were significantly more subjects who had received a radioactive stent in a previous in-stent restenosis (66.7% vs. 0% in patients without second restenosis; P < 0.001), or who had received two radioactive stents (83.3% vs. 33.3%; P = 0.038). After 18 months, TLR rate was 33.3%, and two patients (9.5%) had died. Restenosis after intravascular radiotherapy can be safely treated by percutaneous interventional techniques, yielding an acceptable clinical result within 18 months.
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Acknowledgements
We wish to thank Alfred Hefner, Ph.D., from the Austrian Research Center Seibersdorf for his valuable support in the process of obtaining governmental approval for the use of radioactive stents in our catheterization laboratory.
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Wexberg, P., Beran, G., Lang, I. et al. Percutaneous Interventions in Radiation-Associated Coronary In-Stent Restenosis . CVIR 26, 154–157 (2003). https://doi.org/10.1007/s00270-002-2644-z
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DOI: https://doi.org/10.1007/s00270-002-2644-z