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Preliminary Experience with Locoregional Intraarterial Chemotherapy of Uterine Cervical or Endometrial Cancer Using the Peripheral Implantable Port System (PIPS™): A Feasibility Study

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Abstract

The purpose of this study was to assess the suitability of a percutaneously implantable catheter port system (PIPS) for repeated intraarterial locoregional chemotherapy (ILC) for cervical and endometrial carcinoma. In 30 patients with advanced, recurrent, or high-risk cervical (n = 23) or endometrial (n = 7) carcinoma, PIPS for ILC was implanted via a femoral access, the catheter localized in the infrarenal abdominal aorta. Chemotherapy was performed adjuvantly after surgery (n = 14) or neo-adjuvantly to enable surgery, or for palliation (n = 16). Port implantation, catheter placement, and repeated port puncture was uneventful in all patients. Complications included catheter dislocation (n = 1), catheter thrombosis (n = 2), subcutaneous infection (n = 1), port-bed skin atrophy (n = 1), requiring port explantation in 3 patients. At 2 years follow-up, complete remission was observed in 7/14 patients with adjuvant chemotherapy, partial remission in 3/14. Successful down-staging could be achieved in 4/8 patients with neo-adjuvant chemotherapy. The PIPS is suitable for repeated ILC which may be a valuable method for pre- and post-surgical therapy of advanced or high-risk cervical and endometrial cancer, for adjuvant chemotherapy as well as neo-adjuvantly for down-staging, or for palliation.

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Authors and Affiliations

  1. Depts. of Diagnostic Imaging, Interventional Radiology, and Nuclear Medicine, Diakonissenkrankenhaus Karlsruhe, Germany

    Ernst-Peter Strecker, Irene Boos & Dieter Göttmann

  2. Depts. of Gynecology and Obstetrics, Städtisches Klinikum Pforzheim, Germany

    Ralf Heber & Dirk Heinrich

Authors
  1. Ernst-Peter Strecker
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  2. Ralf Heber
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  3. Irene Boos
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  4. Dieter Göttmann
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  5. Dirk Heinrich
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Strecker, EP., Heber, R., Boos, I. et al. Preliminary Experience with Locoregional Intraarterial Chemotherapy of Uterine Cervical or Endometrial Cancer Using the Peripheral Implantable Port System (PIPS™): A Feasibility Study . CVIR 26, 118–122 (2003). https://doi.org/10.1007/s00270-002-2551-3

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  • DOI: https://doi.org/10.1007/s00270-002-2551-3

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