Abstract.
A new therapy complementary to transcatheter arterial embolization (TAE) in which anticancer agents are percutaneously injected into the tumor under ultrasound guidance (percutaneous injection chemotherapy combined with TAE; TAE-PICT) has been developed and found to be effective. A total of 68 hepatocellular carcinoma (HCC) nodules in 50 patients were treated with TAE-PICT, and the complications were evaluated. Among those with solitary HCC nodules 5 cm in diameter, 17 were treated with TAE-PICT and 24 with only TAE in a prospective comparative study. No major complications were seen, and the anticancer drugs could still be found in the tumor 3 months after injection. A significantly higher cumulative survival rate (p = 0.03961) and significantly higher cumulative recurrence-free survival rate (p = 0.00647) were achieved in patients treated with TAE-PICT than in those treated with TAE alone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Paolucci, V., Schaeff, B., Schneider, M., Gutt, C.: Tumor seeding following laparoscopy: international survey. World J. Surg. 23:989, 1999
Fahim, R.B., McDonald, J.R., Richards, J.C., Ferris, D.O.: Carcinoma of the gallbladder: a study of its mode of spread. Ann. Surg. 156:114, 1962
Ricardo, A.E., Feig, B.W., Ellis, L.M., Hunt, K.K., Curley, S.A., Mc- Fayden, B.V., Jr., Mansfield, P.F.: Gallbladder cancer and trocar site recurrence. Am. J. Surg. 174:619, 1997
Suzuki, K., Kimura, T., Ogawa, H.: Is laparoscopic cholecystectomy hazardous for gallbladder cancer? Surgery 123:311, 1998
Yamaguchi, K., Chijiiwa, K., Saiki, S., Nishihara, K., Takashima, M., Kawakami, K., Tanaka, M.: Retrospective analysis of 70 operations for gallbladder carcinoma. Br. J. Surg. 84:200, 1997
Gollackner, B., Langle, F., Auer, H., Maier, A., Mittleböck, M., Agstner, I., Karner, J., Langer, F., Aspöck, H., Loidolt, H., Rockenschaub, S., Steininger, R.: Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J. Surg. 24:717, 2000
Akoglu, M., Davidson, B.R.: A rational approach to the terminology of hydatid disease of the liver. J. Infect. 24:1, 1992
Langer, J.C., Rose, D.B., Keystone, J.S., Taylor, B.R., Langer, B.: Diagnosis and management of hydatid disease of the liver: a 15-year North American experience. Ann. Surg. 199:412, 1984
Safioleas, M., Misiakos, E., Manti, C., Katsikas, D., Skalkeas, G.: Diagnostic evaluation and surgical management of hydatid disease of the liver. World J. Surg. 18:859, 1994
Atalay, F., Kirimlioglu, V., Gundogdu, H., Akincioglu, T., Gencer, A.: Surgery for hydatid cyst of the liver. Hiroshima J. Med. Sci. 44:89, 1995
Alfieri, S., Doglietto, G.B., Pacelli, F., Costamagna, G., Carriero, C., Mutignani, M., Liberatori, M., Crucitti, F.: Radical surgery for liver hydatid disease: a study of 89 consecutive patients. Hepatogastroenterology 44:496, 1997
Atalay, F., Kirimlioglu, V., Gundogdu, H., Akincioglu, T., Gencer, A.: Surgery for hydatid cysts of the liver. Hiroshima J. Med. Sci. 44:89, 1995
Gollackner, B., Langle, F., Auer, H., Maier, A., Mittlbock, M., Agstner, I., Karner, J., Langer, F., Aspock, H., Loidolt, H., Rockenschaub, S., Steininger, R.: Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J. Surg. 24:717, 2000
Magistrelli, P., Masetti, R., Coppola, R., Messia, A., Nuzzo, G., Picciocchi, A.: Surgical treatment of hydatid disease of the liver: a 20-year experience. Arch Surg. 126:518, 1991
Morris, D.L., Smith, P.G.: Albendazole in hydatid disease: hepatocellular toxicity Trans. R. Soc. Trop. Med. Hyg. 81:343, 1987
Elhamel, A.: Pericystectomy for the treatment of hepatic hydatid cysts. Surgery 107:316, 1990
Gonzales, E.M., Selas, P.R., Martinez, B., Garcia, G., Carazo, F.P., Pascal, M.H.: Results of surical treatment of hepatic hydatosis: current therapeutic modifications. World J. Surg. 13:88, 1989
Mottaghian, H., Saidi, F.: Postoperative recurrence of hydatid disease. Br. J. Surg. 65:237, 1978
Little, J.M., Hollands, M.J., Ekberg, H.: Recurrence of hydatid disease. World J. Surg. 12:700, 1988
Turkcapar, A.G., Ersoz, S., Gungor, C., Aydinuraz, K., Yerdel, M.A., Aras, N.: Surgical treatment of hepatic hydatidosis combined with perioperative treatment with albendazole. Eur. J. Surg. 163:923, 1997
Langer, J.C., Rose, D.B., Keystone, J.S., Taylor, B.R., Langer, B.: Diagnosis and management of hydatid disease of the liver: a 15-year North American experience. Ann. Surg. 199:412, 1984
Safioleas, M., Misiakos, E., Manti, C., Katsikas, D., Skalkeas, G.: Diagnostic evaluation and surgical management of hydatid disease of the liver. World J. Surg. 18:859, 1994
Moreno-Gonzalez, E., Loinaz Segurola, C., Garcia Urena, M.A., Garcia Garcia, I., Gomez Sanz, R., Jimenez Romero, C., Gonzalez Pinto, I., Corral Sanchez, M.A., Palma Carazo, F.: Liver transplantation for Echinococcus granulosus hydatid disease. Transplantation 58:797, 1994
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sarli, L., Costi, R., Kayaalp, C. et al. Letters to the Editor. World J. Surg. 25, 387–389 (2001). https://doi.org/10.1007/s002680020155
Published:
Issue Date:
DOI: https://doi.org/10.1007/s002680020155