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Kidney Transplantation and Obesity: Are There Any Differences in Outcomes?

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Abstract

Introduction

Kidney transplantation (KT) is the gold standard treatment for end-stage renal disease (ESRD) patients. Obesity is a strong risk factor for developing cardiovascular disease, chronic kidney disease, and ESRD. This study aimed to investigate the outcomes of kidney transplantation in obese recipients.

Material and methods

We retrospectively reviewed the medical records of recipients from January 2016 to December 2021 in a single center. Outcomes in recipients of a kidney allograft with BMI ≥ 30 were compared with the outcomes in recipients with 30 < BMI.

Results

A total of 467 consecutive kidney transplantation recipients’ files were studied. 213 (45.6%) allograft recipients had a BMI ≥ 30, and 254 (54.4%) allograft recipients had a BMI < 30. DGF rate was 29.1% in the BMI ≥ 30 and 30.7% in the BMI < 30 group (P = 0.41). On the other hand, 30 days readmission rate also did not show a significant difference between the BMI ≥ 30 and BMI < 30 allograft recipients (37 vs. 33.8%, P = 0.46). The mean overall costs of transplantation in the BMI ≥ 30 group was $254,395, and it was $256,029 in the BMI < 30 group (P = 0.84).

Conclusion

Our study shows that the outcomes of renal allograft transplant were comparable between recipients with BMI ≥ 30 and BMI < 30 in terms of DGF, LOS, 30 days readmission, acute rejection rate, and survival rates, and BMI should not be a single independent criterion for decision making to select an optimal recipient.

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Abbreviations

BMI:

Body mass index

CIT:

Cold ischemia time

DGF:

Delayed graft function

DVT:

Deep vein thrombosis

EPIC:

Electronic medical record system

ESRD:

End-stage renal disease

KDPI:

Kidney risk profile index

KT:

Kidney transplantation

LOS:

Length of stay

PRA:

Panel reactive antibodies

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Funding

The authors declare that there was no source of funding for this project.

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Authors and Affiliations

  1. Division of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA

    Mahmoudreza Moein, Melanie Tacher Otero, Gavrielle J. Rood, Matthew Hanlon & Reza Saidi

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  1. Mahmoudreza Moein
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  2. Melanie Tacher Otero
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  3. Gavrielle J. Rood
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  4. Matthew Hanlon
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  5. Reza Saidi
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Correspondence to Reza Saidi.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Moein, M., Otero, M.T., Rood, G.J. et al. Kidney Transplantation and Obesity: Are There Any Differences in Outcomes?. World J Surg 47, 510–518 (2023). https://doi.org/10.1007/s00268-022-06806-4

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