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Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

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Abstract

Background

This study’s objective was to conduct a multinational registry of patients with carotid body tumors (CBTs) and to analyze patients’ clinical characteristics, treatments, and outcomes.

Methods

Retrospective study from the Carotid Paraganglioma Cooperative International Registry involving eleven medical centers in Bolivia, Ecuador, Mexico, and Spain, of all patients with a CBT who underwent resection between 2009 and 2019.

Results

A total of 1432 patients with a CBT surgically treated were included. Median patient age was 54 years (range: 45–63 years), and 82.9% (1184) of the study cohort were female. While at low altitude, the proportion of female-to-male cases was 2:1, at high altitude, this proportion increased to 8:1, with statistically significant differences (p = .022). Median operative time was 139 min (range: 110–180 min), while median operative blood loss was 250 ml (range: 100–500 ml), with statistically significant difference in increased blood loss (p = .001) and operative time (p = .001) with a higher Shamblin classification. Eight (0.6%) patients suffered stroke. Univariate analysis analyzing for possible factors associated with increased odds of stroke revealed intraoperative vascular lesion to present an OR of 2.37 [CI 95%; 1.19–4.75] (p = 0.001). In 245 (17.1%), a cranial nerve injury was reported. Seven (0.5%) deaths were recorded.

Conclusion

The most common CBT type on this cohort was hyperplasic, which might be partially explained by the high altitudes where these patients lived. Increased blood loss and operative time were associated with a higher Shamblin classification, and the risk of stroke was associated with patients presenting transoperative vascular lesions.

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Acknowledgements

CAPACITY collaborators: Edgar Geovanny Cárdenas Figueroa, MD—Hospital de Especialidades Carlos Andrade Marín, Quito, Ecuador, Verónica Elizabeth Borja Rojas, MD—Hospital de Especialidades Carlos Andrade Marín, Quito, Ecuador. Ingrid Valeria Salinas Ramos, MD—Hospital Obrero Nº1, La Paz, Bolivia. Alfonso Juan Gonzalez-Valladares, MD—Hospital de Especialidades del Centro Médico Nacional Siglo XXI, CDMX, México. Aneiva Claudia Katherine Perez, MD—Hospital Obrero Nº1, La Paz, Bolivia. Gael Bañuelos-Gutierrez, MD—Hospital de Especialidades del Centro Médico Nacional Siglo XXI, CDMX, México. Jesus Isaias Garcia Palafox, MD—Instituto Mexicano del Seguro Social (IMSS) HGZ 8, CDMX, México. Gregorio Fernando Gardeazabal-Diaz, MD—Hospital Obrero Nº1, La Paz, Bolivia. César Armando López Aldayuz, MD—Seguro Banca Privada, La Paz, Bolivia. José Ángel Barajas-Colón, MD—Hospital de Especialidades del Centro Médico Nacional Siglo XXI, CDMX, México.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector.

Author information

Authors and Affiliations

  1. Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710, Monterrey, N.L., Mexico

    Mauricio Gonzalez-Urquijo, Andrea Becerril-Gaitan, David Hinojosa-Gonzalez & Mario Alejandro Fabiani

  2. Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103, Quito, Ecuador

    Victor Hugo Viteri-Pérez, Victor Hugo Jaramillo-Vergara, Edgar Geovanny Cárdenas-Figueroa & Verónica Elizabeth Borja-Rojas

  3. Hospital de Especialidades CMN La Raza, Av. Hospital Benito Juárez 4, La Raza, Azcapotzalco, 02990, Mexico City, CDMX, Mexico

    María Elizabeth Enríquez-Vega

  4. Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia

    Ivan Walter Soto Vaca Guzmán, Ingrid Valeria Salinas-Ramos, Aneiva Claudia Katherine-Perez & Gregorio Fernando Gardeazabal-Diaz

  5. Hospital Santa Bárbara, Destacamento 111, Sucre, Bolivia

    Gregorio Eloy Valda-Ameller

  6. Hospital Dr. Jaime Mendoza, El Villar, Sucre, Bolivia

    Gregorio Eloy Valda-Ameller

  7. Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720, Mexico City, CDMX, Mexico

    José de Jesús García-Pérez, Alfonso Juan Gonzalez-Valladares, Gael Bañuelos-Gutierrez & José Ángel Barajas-Colón

  8. Hospital Clínico Universitario de Valladolid, Av. Ramón Y Cajal, 3, 47003, Valladolid, Spain

    Carlos Vaquero-Puerta

  9. Instituto Mexicano del Seguro Social (IMSS) UMAE 189, Av. Cuauhtémoc, Formando Hogar, 91810, Veracruz, , Ve, Mexico

    Miguel Angel Cisneros-Tinoco

  10. Hospital Central Universitario, C. Antonio Rosales 33000, Obrera, 31350, Chihuahua, Chih., Mexico

    Joaquin Miguel Santoscoy-Ibarra

  11. Instituto Mexicano del Seguro Social (IMSS) HGZ 8, CDMX, Mexico

    Jesus Isaias Garcia-Palafox

  12. Seguro Banca Privada, La Paz, Bolivia

    César Armando López-Aldayuz

Authors
  1. Mauricio Gonzalez-Urquijo
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  2. Victor Hugo Viteri-Pérez
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  3. Andrea Becerril-Gaitan
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  4. David Hinojosa-Gonzalez
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  5. María Elizabeth Enríquez-Vega
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  6. Ivan Walter Soto Vaca Guzmán
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  7. Gregorio Eloy Valda-Ameller
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  8. José de Jesús García-Pérez
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  9. Carlos Vaquero-Puerta
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  10. Victor Hugo Jaramillo-Vergara
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  11. Miguel Angel Cisneros-Tinoco
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  12. Joaquin Miguel Santoscoy-Ibarra
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  13. Mario Alejandro Fabiani
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Consortia

CAPACITY

  • Edgar Geovanny Cárdenas-Figueroa
  • , Verónica Elizabeth Borja-Rojas
  • , Ingrid Valeria Salinas-Ramos
  • , Alfonso Juan Gonzalez-Valladares
  • , Aneiva Claudia Katherine-Perez
  • , Gael Bañuelos-Gutierrez
  • , Jesus Isaias Garcia-Palafox
  • , Gregorio Fernando Gardeazabal-Diaz
  • , César Armando López-Aldayuz
  •  & José Ángel Barajas-Colón

Contributions

Mauricio Gonzalez-Urquijo, Victor Hugo Viteri-Pérez, Andrea Becerril-Gaitan, David Hinojosa-Gonzalez, Mario Alejandro Fabiani contributed to the study conceptualization and methodology. Mario Alejandro Fabiani should be recognized for the project administration and supervision. Victor Hugo Viteri-Pérez, María Elizabeth Enríquez-Vega, Ivan Walter Soto Vaca Guzmán, Gregorio Eloy Valda Ameller, José de Jesús García-Pérez, Carlos Vaquero-Puerta, Victor Hugo Jaramillo-Vergara, Miguel Angel Cisneros-Tinoco, Joaquin Miguel Santoscoy-Ibarra performed the data collection and interpretation. David Hinojosa-Gonzalez and Andrea Becerril-Gaitan performed the formal analyses, writing of the original draft and visualization. Andrea Becerril-Gaitan, Victor Hugo Viteri-Pérez, Mario Alejandro Fabiani, David Hinojosa-Gonzalez and Mauricio Gonzalez-Urquijo reviewed and edited the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mario Alejandro Fabiani.

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Gonzalez-Urquijo, M., Viteri-Pérez, V.H., Becerril-Gaitan, A. et al. Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group. World J Surg 46, 2507–2514 (2022). https://doi.org/10.1007/s00268-022-06663-1

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