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Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study



This study aims to investigate the association between preoperative Red blood cell Distribution Width (RDW) and postoperative outcomes, including myocardial infarction (MI), and mortality.


A prospective cohort including all patients submitted to elective vascular arterial surgery at a university hospital. The primary and secondary outcomes were 30-day mortality and 30-day MI, respectively.


Atrial fibrillation, chronic kidney disease (CKD), and dependent functional status were more prevalent in deceased patients. After multivariable analysis, age (adjusted OR 1.08, 95% Confidence Interval [1.01–1.15], p = 0.027) and RDW-standard deviation (RDW-SD) (1.08 [1.01–1.16], p = 0.032) remained independent predictors of mortality. Patients with MI had higher rates of diabetes, CKD, dependent functional status, ASA physical status IV, and insulin medication. After multivariable analysis, dependent functional status (4.8 [1.6–15.0], p = 0.007), insulin medication (4.4 [1.5–12.6], p = 0.007) and RDW-SD (1.10 [1.02–1.19], p = 0.020) were independent predictors of MI.


RDW-SD independently predicted postoperative MI and mortality, and may provide valuable information for prevention and early management of adverse outcomes.

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All authors made a substantial contribution to the concept and design, acquisition of data or analysis and interpretation of data; drafted the article or revised it critically for important intellectual content and approved the final version to be published.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Correspondence to Pedro José Vinhais Domingues Videira Reis.

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Caldeira de Albuquerque, F.V.S., Dias-Neto, M.F., Rocha-Neves, J.M.P. et al. Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study. World J Surg 46, 957–965 (2022).

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