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Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study

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Abstract

Background

This study aims to investigate the association between preoperative Red blood cell Distribution Width (RDW) and postoperative outcomes, including myocardial infarction (MI), and mortality.

Methods

A prospective cohort including all patients submitted to elective vascular arterial surgery at a university hospital. The primary and secondary outcomes were 30-day mortality and 30-day MI, respectively.

Results

Atrial fibrillation, chronic kidney disease (CKD), and dependent functional status were more prevalent in deceased patients. After multivariable analysis, age (adjusted OR 1.08, 95% Confidence Interval [1.01–1.15], p = 0.027) and RDW-standard deviation (RDW-SD) (1.08 [1.01–1.16], p = 0.032) remained independent predictors of mortality. Patients with MI had higher rates of diabetes, CKD, dependent functional status, ASA physical status IV, and insulin medication. After multivariable analysis, dependent functional status (4.8 [1.6–15.0], p = 0.007), insulin medication (4.4 [1.5–12.6], p = 0.007) and RDW-SD (1.10 [1.02–1.19], p = 0.020) were independent predictors of MI.

Conclusion

RDW-SD independently predicted postoperative MI and mortality, and may provide valuable information for prevention and early management of adverse outcomes.

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Acknowledgements

All authors made a substantial contribution to the concept and design, acquisition of data or analysis and interpretation of data; drafted the article or revised it critically for important intellectual content and approved the final version to be published.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Faculty of Medicine, University of Porto, Porto, Portugal

    Francisca Vieira da Silva Caldeira de Albuquerque

  2. Department of Angiology and Vascular Surgery, São João University Hospital Center, Porto, Portugal

    Marina Felicidade Dias-Neto & João Manuel Palmeira da Rocha-Neves

  3. Faculty of Medicine, Surgery and Physiology–Cardiovascular R&D Centre (UNIC), University of Porto, Porto, Portugal

    Marina Felicidade Dias-Neto

  4. Biomedicine Department–Unit of Anatomy, Faculty of Medicine, University of Porto, Porto, Portugal

    João Manuel Palmeira da Rocha-Neves

  5. Burn Unit–Department of Plastic Surgery, São João University Hospital Center, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal

    Pedro José Vinhais Domingues Videira Reis

Authors
  1. Francisca Vieira da Silva Caldeira de Albuquerque
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  2. Marina Felicidade Dias-Neto
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  3. João Manuel Palmeira da Rocha-Neves
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  4. Pedro José Vinhais Domingues Videira Reis
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Correspondence to Pedro José Vinhais Domingues Videira Reis.

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Caldeira de Albuquerque, F.V.S., Dias-Neto, M.F., Rocha-Neves, J.M.P. et al. Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study. World J Surg 46, 957–965 (2022). https://doi.org/10.1007/s00268-022-06441-z

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  • DOI: https://doi.org/10.1007/s00268-022-06441-z

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