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Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery

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Abstract

Background

Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety.

Methods

Incidences of global postoperative morbidities and major abdominal morbidities were compared between 101 consecutive patients who received a sheet-type adhesion barrier (Interceed®) and 134 patients who did not receive any adhesion barriers during hepatectomy. Propensity score (PS) adjustment was used to account for potential bias to receive Interceed.

Results

In the PS-adjusted population, the incidences of both global postoperative morbidities and major abdominal morbidities showed no significant difference between the Interceed group and the control group (17.9% vs. 17.6%; P = 0.948 and 7.8% vs. 9.1%; P = 0.813, respectively). Multivariate analysis showed that age + 10 years (odds ratio [OR], 1.70; 95% CI, 1.15–2.50; P = 0.007), estimated blood loss + 100 mL (OR, 1.05; 95% CI, 1.01–1.09, P = 0.009), and laparoscopic approach (OR, 0.10; 95% CI, 0.01–0.75; P = 0.026) were independent predictors for global postoperative morbidities and operation time + 1 h (OR, 1.56; 95% CI, 1.23–1.96; P < 0.001) was a risk factor for major abdominal morbidity, while no specific association between the use of Interceed and the risk of postoperative morbidity was observed.

Conclusions

Use of Interceed does not increase the risk of postoperative morbidities after hepatectomy.

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Funding

This study was supported by study grant from Okinaka Menorial Institute for Medical Disease.

Author information

Author notes

  1. Satoshi Okubo and Junichi Shindoh equally contributed to this work.

Authors and Affiliations

  1. Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minatoku, Tokyo, 105-8470, Japan

    Satoshi Okubo, Junichi Shindoh, Yuta Kobayashi & Masaji Hashimoto

  2. Okinaka Memorial Institute for Medical Disease, Tokyo, Japan

    Junichi Shindoh

Authors
  1. Satoshi Okubo
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  2. Junichi Shindoh
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  3. Yuta Kobayashi
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  4. Masaji Hashimoto
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Corresponding author

Correspondence to Junichi Shindoh.

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Conflict of interest

All authors have no conflict of interest to disclose.

Ethical approval

This study was performed in accordance with the ethical guidelines for clinical study in Japan under approval of the institutional review board of Toranomon Hospital (No. 1919).

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Okubo, S., Shindoh, J., Kobayashi, Y. et al. Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery. World J Surg 44, 4214–4220 (2020). https://doi.org/10.1007/s00268-020-05743-4

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  • DOI: https://doi.org/10.1007/s00268-020-05743-4

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