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The Impact of Hybrid Minimally Invasive Esophagectomy with Neck-Abdominal First Approach on the Short- and Long-Term Outcomes for Esophageal Squamous Cell Carcinoma

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Abstract

Background

Currently, there is no consensus for an optimal minimally invasive esophagectomy (MIE) approach. This study aimed to compare hybrid MIE (hMIE) with neck-abdominal first approach to standard open esophagectomy (OE).

Methods

Data from a cohort of 301 patients were retrospectively analyzed. All participants received either hMIE or OE for the treatment of esophageal squamous cell carcinoma at Tokyo Medical and Dental University between January 2003 and December 2013. Analyses included propensity score matching and the Kaplan–Meier statistical method to determine overall survival (OS) and disease-free survival (DFS) of the cohort.

Results

After one-to-one propensity score matching, there were 68 patient pairs. The hMIE group had significantly lower incidence of severe postoperative complications (20.1% vs. 7.4%; p = 0.026) and severe respiratory complications (7.4% vs. 0%; p = 0.058) than the OE group. The 5-year oncological outcomes of the two groups were almost equivalent (OS: OE, 55.0%; hMIE, 69.0%; p = 0.063 and DFS: OE, 54.0%; hMIE, 62.0%; p = 0.28).

Conclusions

This study compared hMIE with neck-abdominal first approach to standard OE. The results showed significantly less severe postoperative complications for hMIE with neck-abdominal first approach in comparison with OE, without a compromise in long-term oncological outcomes.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8519, Japan

    Akihiro Hoshino, Yasuaki Nakajima, Kenro Kawada, Yutaka Tokairin, Takuya Okada, Toshihiro Matsui, Kazuya Yamaguchi, Tatsuyuki Kawano & Yusuke Kinugasa

Authors
  1. Akihiro Hoshino
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  2. Yasuaki Nakajima
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  3. Kenro Kawada
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  4. Yutaka Tokairin
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  5. Takuya Okada
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  6. Toshihiro Matsui
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  7. Kazuya Yamaguchi
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  8. Tatsuyuki Kawano
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  9. Yusuke Kinugasa
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Corresponding author

Correspondence to Akihiro Hoshino.

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The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Ethics Committee of Tokyo Medical and Dental University (Approval number: M2018-161), and was performed in accordance with the ethical principles of the Helsinki Declaration.

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Written informed consent was obtained from all patients included in the study.

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Hoshino, A., Nakajima, Y., Kawada, K. et al. The Impact of Hybrid Minimally Invasive Esophagectomy with Neck-Abdominal First Approach on the Short- and Long-Term Outcomes for Esophageal Squamous Cell Carcinoma. World J Surg 44, 3829–3836 (2020). https://doi.org/10.1007/s00268-020-05655-3

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  • DOI: https://doi.org/10.1007/s00268-020-05655-3

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