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Surgical Consideration Based on Lymph Nodes Spread Patterns in Patients with Peripheral Right Middle Non-small Cell Lung Cancer 3 cm or Less

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Abstract

Background

The optimal extent of lung resection and lymph nodes dissection for peripheral early-stage right middle non-small cell lung cancer (NSCLC) still remains controversial. In this study, we analyzed the patterns of lymph nodes metastasis (LNM) of patients with peripheral right middle NSCLC ≤ 3 cm, aiming to provide evidences for surgical choice for early-stage peripheral right middle lobe NSCLC.

Methods

We retrospectively investigated the clinical and pathological data of patients diagnosed with peripheral right middle lobe NSCLC ≤ 3 cm between January 2015 and December 2019. The LNM patterns were analyzed by tumor size.

Results

A total of 60 patients were included for analysis. The tumor size was preoperatively divided as follows: ≤ 1 cm (13 patients); > 1 cm but ≤ 2 cm (36 patients); > 2 cm but ≤ 3 cm (11 patients). Fifty-four patients were categorized as N0 group, 1 patient as N1 group, and 5 patients as N2 group. In the upper zone, 3 patients were found to have LNM. In the subcarinal zone, another 3 patients had LNM. But the lymph nodes of all these patients were negative in the lower zone. In station 10, 1 patient (1.67%) was found to have LNM, while in station 11–13, 2 patients (3.33%) were found to have LNM.

Conclusion

For the right middle lobe peripheral NSCLC ≤ 1 cm, sublobar resection with lymph node sampling may be a feasible treatment. For cancers > 1 cm but ≤ 2 cm, lobectomy with lobe-specific lymph node dissection (especially station 2R and 4R) may be a preferred choice. For tumors > 2 cm but ≤ 3 cm, lobectomy with systematic lymph node dissection may still be the standard of care.

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Author notes

  1. Rulan Wang and Han-Yu Deng contributed equally to the study and were co-first authors.

Authors and Affiliations

  1. Lung Cancer Center, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, People’s Republic of China

    Rulan Wang, Han-Yu Deng, Jie Zhou, Rui Jiang & Qinghua Zhou

Authors
  1. Rulan Wang
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  2. Han-Yu Deng
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  3. Jie Zhou
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  4. Rui Jiang
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  5. Qinghua Zhou
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Contributions

QZ contributed to conception and design and provided administrative support; HYD helped in the provision of study materials or patients; RLW, HYD, JZ, and RJ performed collection and assembly of data; RLW and HYD performed data analysis and interpretation; all authors wrote the manuscript and made the final approval of the manuscript.

Corresponding authors

Correspondence to Han-Yu Deng or Qinghua Zhou.

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All authors have read and approved this final version of the manuscript. No conflict of interest exists for any of the authors.

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Wang, R., Deng, HY., Zhou, J. et al. Surgical Consideration Based on Lymph Nodes Spread Patterns in Patients with Peripheral Right Middle Non-small Cell Lung Cancer 3 cm or Less. World J Surg 44, 3530–3536 (2020). https://doi.org/10.1007/s00268-020-05647-3

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