Abstract
Introduction
Endoscopic placement of oesophageal stents may be used in benign oesophageal perforation and oesophageal anastomotic leakage to control sepsis and reduce mortality and morbidity by avoiding thoracotomy. This updated systematic review aimed to assess the safety and effectiveness of oesophageal stents in these two scenarios.
Methods
A systematic literature search of all published studies reporting use of metallic and plastic stents in the management of post-operative anastomotic leaks, spontaneous and iatrogenic oesophageal perforations were identified. Primary outcomes were technical (deploying ≥ 1 stent to occlude site of leakage with no evidence of leakage of contrast within 24–48 h) and clinical success (complete healing of perforation or leakage by placement of single or multiple stents irrespective of whether the stent was left in situ or was removed). Secondary outcomes were stent migration, perforation and erosion, and mortality rates. Subgroup analysis was performed for plastic versus metallic stents and anastomotic leaks versus perforations separately.
Results
A total of 66 studies (n = 1752 patients) were included. Technical and clinical success rates were 96% and 87%, respectively. Plastic stents had significantly higher migration rates (24% vs 16%, p = 0.001) and repositioning (11% vs 3%, p < 0.001) and lower technical success (91% vs 95%, p = 0.032) than metallic stents. In patients with anastomotic leaks, plastic stents were associated with higher stent migration (26% vs 15%, p = 0.034), perforation (2% vs 0%, p = 0.013), repositioning (10% vs 0%, p < 0.001), and lower technical success (95% vs 100%, p = p = 0.002). In patients with perforations only, plastic stents were associated with significantly lower technical success (85% vs 99%, p < 0.001).
Conclusions
Covered metallic oesophageal stents appear to be more effective than plastic stents in the management of oesophageal perforation and anastomotic leakage. However, quality of evidence of generally poor and high-quality randomised trial is needed to further evaluate best management option for oesophageal perforation and anastomotic leakage.
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References
Markar S, Gronnier C, Duhamel A et al (2015) The impact of severe anastomotic leak on long-term survival and cancer recurrence after surgical resection for esophageal malignancy. Ann Surg 262(6):972–980
Goense L, van Dijk WA, Govaert JA et al (2017) Hospital costs of complications after esophagectomy for cancer. Eur J Surg Oncol 43(4):696–702
Messager M, Warlaumont M, Renaud F et al (2017) Recent improvements in the management of esophageal anastomotic leak after surgery for cancer. Eur J Surg Oncol 43(2):258–269
Rutegard M, Lagergren P, Rouvelas I et al (2012) Intrathoracic anastomotic leakage and mortality after esophageal cancer resection: a population-based study. Ann Surg Oncol 19(1):99–103
Junemann-Ramirez M, Awan MY, Khan ZM et al (2005) Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. Eur J Cardiothorac Surg 27(1):3–7
Sauvanet A, Mariette C, Thomas P et al (2005) Mortality and morbidity after resection for adenocarcinoma of the gastroesophageal junction: predictive factors. J Am Coll Surg 201(2):253–262
Griffin SM, Shaw IH, Dresner SM (2002) Early complications after Ivor Lewis subtotal esophagectomy with two-field lymphadenectomy: risk factors and management. J Am Coll Surg 194(3):285–297
Dasari BV, Neely D, Kennedy A et al (2014) The role of esophageal stents in the management of esophageal anastomotic leaks and benign esophageal perforations. Ann Surg 259(5):852–860
Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700
Slim K, Nini E, Forestier D et al (2003) Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73(9):712–716
Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283(15):2008–2012
Evrard S, Le Moine O, Lazaraki G et al (2004) Self-expanding plastic stents for benign esophageal lesions. Gastrointest Endosc 60(6):894–900
Kim AW, Liptay MJ, Snow N et al (2008) Utility of silicone esophageal bypass stents in the management of delayed complex esophageal disruptions. Ann Thorac Surg 85(6):1962–1967 (discussion 1967)
Zhou JH, Gong TQ, Jiang YG et al (2009) Management of delayed intrathoracic esophageal perforation with modified intraluminal esophageal stent. Dis Esophagus 22(5):434–438
Dent B, Griffin SM, Jones R et al (2016) Management and outcomes of anastomotic leaks after oesophagectomy. Br J Surg 103(8):1033–1038
van Boeckel PG, Sijbring A, Vleggaar FP et al (2011) Systematic review: temporary stent placement for benign rupture or anastomotic leak of the oesophagus. Aliment Pharmacol Ther 33(12):1292–1301
Freeman RK, Ascioti AJ, Dake M et al (2015) An Assessment of the Optimal Time for Removal of Esophageal Stents Used in the Treatment of an Esophageal Anastomotic Leak or Perforation. Ann Thorac Surg 100(2):422–428
Fischer A, Thomusch O, Benz S et al (2006) Nonoperative treatment of 15 benign esophageal perforations with self-expandable covered metal stents. Ann Thorac Surg 81(2):467–472
Vermeulen BD, Siersema PD (2018) Esophageal stenting in clinical practice: an overview. Curr Treat Options Gastroenterol 16(2):260–273
Yakoub D, Fahmy R, Athanasiou T et al (2008) Evidence-based choice of esophageal stent for the palliative management of malignant dysphagia. World J Surg 32(9):1996–2009
Mozafari H, Dong P, Zhao S et al (2018) Migration resistance of esophageal stents: The role of stent design. Comput Biol Med 100:43–49
Diana M, Swanstrom LL, Halvax P et al (2015) Esophageal covered stent fixation using an endoscopic over-the-scope clip Mechanical proof of the concept and first clinical experience. Surg Endosc 29(11):3367–3372
Shim CS, Cho YD, Moon JH et al (2001) Fixation of a modified covered esophageal stent: its clinical usefulness for preventing stent migration. Endoscopy 33(10):843–848
Vanbiervliet G, Filippi J, Karimdjee BS et al (2012) The role of clips in preventing migration of fully covered metallic esophageal stents: a pilot comparative study. Surg Endosc 26(1):53–59
Law R, Prabhu A, Fujii-Lau L et al (2018) Stent migration following endoscopic suture fixation of esophageal self-expandable metal stents: a systematic review and meta-analysis. Surg Endosc 32(2):675–681
Siersema PD, Tan TG, Sutorius FF et al (1997) Massive hemorrhage caused by a perforating Gianturco-Z stent resulting in an aortoesophageal fistula. Endoscopy 29(5):416–420
Unosawa S, Hata M, Sezai A et al (2008) Surgical treatment of an aortoesophageal fistula caused by stent implantation for esophageal stenosis: report of a case. Surg Today 38(1):62–64
Um SJ, Park BH, Son C (2009) An aortoesophageal fistula in patient with lung cancer after chemo-irradiation and subsequent esophageal stent implantation. J Thorac Oncol 4(2):263–265
Rogart J, Greenwald A, Rossi F et al (2007) Aortoesophageal fistula following Polyflex stent placement for refractory benign esophageal stricture. Endoscopy 39(Suppl 1):E321–E322
Ahn M, Shin BS, Park MH (2010) Aortoesophageal fistula secondary to placement of an esophageal stent: emergent treatment with cyanoacrylate and endovascular stent graft. Ann Vasc Surg 24(4):555
Siewert JR, Stein HJ, Bartels H (2004) Anastomotic leaks in the upper gastrointestinal tract. Chirurg 75(11):1063–1070
Kauer WK, Stein HJ, Dittler HJ et al (2008) Stent implantation as a treatment option in patients with thoracic anastomotic leaks after esophagectomy. Surg Endosc 22(1):50–53
Griffin SM, Lamb PJ, Dresner SM et al (2001) Diagnosis and management of a mediastinal leak following radical oesophagectomy. Br J Surg 88(10):1346–1351
Licht E, Markowitz AJ, Bains MS et al (2016) Endoscopic Management of Esophageal Anastomotic Leaks After Surgery for Malignant Disease. Ann Thorac Surg 101(1):301–304
Schweigert M, Solymosi N, Dubecz A et al (2014) One decade of experience with endoscopic stenting for intrathoracic anastomotic leakage after esophagectomy: brilliant breakthrough or flash in the pan? Am Surg 80(8):736–745
van Halsema EE, van Hooft JE (2015) Clinical outcomes of self-expandable stent placement for benign esophageal diseases: a pooled analysis of the literature. World J Gastrointest Endosc 7(2):135–153
Kuehn F, Loske G, Schiffmann L et al (2017) Endoscopic vacuum therapy for various defects of the upper gastrointestinal tract. Surg Endosc 31(9):3449–3458
Newton NJ, Sharrock A, Rickard R et al (2017) Systematic review of the use of endo-luminal topical negative pressure in oesophageal leaks and perforations. Dis Esophagus 30(3):1–5
Virgilio E, Ceci D, Cavallini M (2018) Surgical Endoscopic Vacuum-assisted Closure Therapy (EVAC) in Treating Anastomotic Leakages After Major Resective Surgery of Esophageal and Gastric Cancer. Anticancer Res 38(10):5581–5587
Pournaras DJ, Hardwick RH, Safranek PM et al (2018) Endoluminal Vacuum Therapy (E-Vac): a Treatment Option in Oesophagogastric Surgery. World J Surg 42(8):2507–2511
Kamarajah SK SP, Bundred J, Siaw-Acheampong K, Jefferies B, Nepogodiev D, Evans R, Mohamed I, Wanigsooriya K, McKay S, Whitehouse T, Alderson D, Gossage J, Hillegersberg RV, Vohra R, Griffiths EA. International Variation in Surgical Practices in Units performing Oesophagectomy for Oesophageal Cancer: A Unit Survey of the participants of the Oesophagogastric Anastomosis Audit (OGAA). Association of Upper Gastrointestinal Surgery 2018. Edinburgh: British Journal of Surgery, 2018
Evans RPT SP, Nepogodiev D, Bundred J, Kamarajah S, Jefferies B, Siaw- Acheampong K, Wanigasooriya K, McKay S, Mohamed I, Whitehouse T, Alderson D, Gossage J, van Hillegersberg R, Vohra RS, Griffiths EA. Study protocol for a multi-centre, prospective, cohort study on oesophago-gastric anastomoses and anastomotic leak (The Oesophago-Gastric Anastomosis Audit/OGAA). Disease of Esophagus 2018
Pajarinen J, Ristkari SK, Mokka RE (1999) A report of three cases with an oesophageal perforation treated with a coated self-expanding stent. Ann Chir Gynaecol 88(4):332–334
Roy-Choudhury SH, Nicholson AA, Wedgwood KR et al (2001) Symptomatic malignant gastroesophageal anastomotic leak: management with covered metallic esophageal stents. AJR Am J Roentgenol 176(1):161–165
Doniec JM, Schniewind B, Kahlke V et al (2003) Therapy of anastomotic leaks by means of covered self-expanding metallic stents after esophagogastrectomy. Endoscopy 35(8):652–658
Siersema PD, Homs MY, Haringsma J et al (2003) Use of large-diameter metallic stents to seal traumatic nonmalignant perforations of the esophagus. Gastrointest Endosc 58(3):356–361
Johnsson E, Lundell L, Liedman B (2005) Sealing of esophageal perforation or ruptures with expandable metallic stents: a prospective controlled study on treatment efficacy and limitations. Dis Esophagus 18(4):262–266
Koch S, Weber A, Fein F et al (2005) Esophageal stents as a salvage therapy for non-malignant iatrogenic esophageal perforations. Gastroenterol Clin Biol 29(6–7):735–739
Han XW, Li YD, Wu G et al (2006) New covered mushroom-shaped metallic stent for managing anastomotic leak after esophagogastrostomy with a wide gastric tube. Ann Thorac Surg 82(2):702–706
Eisendrath P, Cremer M, Himpens J et al (2007) Endotherapy including temporary stenting of fistulas of the upper gastrointestinal tract after laparoscopic bariatric surgery. Endoscopy 39(7):625–630
Tuebergen D, Rijcken E, Mennigen R et al (2008) Treatment of thoracic esophageal anastomotic leaks and esophageal perforations with endoluminal stents: efficacy and current limitations. J Gastrointest Surg 12(7):1168–1176
Amrani L, Menard C, Berdah S et al (2009) From iatrogenic digestive perforation to complete anastomotic disunion: endoscopic stenting as a new concept of “stent-guided regeneration and re-epithelialization”. Gastrointest Endosc 69(7):1282–1287
Babor R, Talbot M, Tyndal A (2009) Treatment of upper gastrointestinal leaks with a removable, covered, self-expanding metallic stent. Surg Laparosc Endosc Percutan Tech 19(1):e1–e4
Leers JM, Vivaldi C, Schafer H et al (2009) Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent. Surg Endosc 23(10):2258–2262
Salminen P, Gullichsen R, Laine S (2009) Use of self-expandable metal stents for the treatment of esophageal perforations and anastomotic leaks. Surg Endosc 23(7):1526–1530
Blackmon SH, Santora R, Schwarz P, et al. Utility of removable esophageal covered self-expanding metal stents for leak and fistula management. Ann Thorac Surg 2010; 89(3):931-6; discussion 936-7
Kiernan PD, Khandhar SJ, Fortes DL et al (2010) Thoracic esophageal perforations. Am Surg 76(12):1355–1362
Lee KM, Shin SJ, Hwang JC et al (2010) Proximal-releasing stent insertion under transnasal endoscopic guidance in patients with postoperative esophageal leakage. Gastrointest Endosc 72(1):180–185
Cerna M, Kocher M, Valek V et al (2011) Covered biodegradable stent: new therapeutic option for the management of esophageal perforation or anastomotic leak. Cardiovasc Intervent Radiol 34(6):1267–1271
Hirdes MM, Vleggaar FP, Van der Linde K et al (2011) Esophageal perforation due to removal of partially covered self-expanding metal stents placed for a benign perforation or leak. Endoscopy 43(2):156–159
Inbar R, Santo E, Subchi Ael A et al (2011) Insertion of removable self-expanding metal stents as a treatment for postoperative leaks and perforations of the esophagus and stomach. Isr Med Assoc J 13(4):230–233
Koivukangas V, Biancari F, Merilainen S et al (2012) Esophageal stenting for spontaneous esophageal perforation. J Trauma Acute Care Surg 73(4):1011–1013
Al-issa MA, Petersen TI, Taha AY et al (2014) The role of esophageal stent placement in the management of postesophagectomy anastomotic leak. Saudi J Gastroenterol 20(1):39–42
Ben-David K, Behrns K, Hochwald S et al (2014) Esophageal perforation management using a multidisciplinary minimally invasive treatment algorithm. J Am Coll Surg 218(4):768–774
Navaneethan U, Lourdusamy V, Duvuru S et al (2015) Timing of esophageal stent placement and outcomes in patients with esophageal perforation: a single-center experience. Surg Endosc 29(3):700–707
Rajan PS, Bansal S, Balaji NS et al (2014) Role of endoscopic stents and selective minimal access drainage in oesophageal leaks: feasibility and outcome. Surg Endosc 28(8):2368–2373
Gonzalez JM, Garces Duran R, Vanbiervliet G et al (2015) Double-type metallic stents efficacy for the management of post-operative fistulas, leakages, and perforations of the upper gastrointestinal tract. Surg Endosc 29(7):2013–2018
Persson S, Rouvelas I, Kumagai K et al (2016) Treatment of esophageal anastomotic leakage with self-expanding metal stents: analysis of risk factors for treatment failure. Endosc Int Open 4(4):E420–E426
van den Berg MW, Kerbert AC, van Soest EJ et al (2016) Safety and efficacy of a fully covered large-diameter self-expanding metal stent for the treatment of upper gastrointestinal perforations, anastomotic leaks, and fistula. Dis Esophagus 29(6):572–579
Liang DH, Hwang E, Meisenbach LM et al (2017) Clinical outcomes following self-expanding metal stent placement for esophageal salvage. J Thorac Cardiovasc Surg 154(3):1145–1150
Sousa P, Castanheira A, Martins D et al (2017) Treatment of Postoperative Leaks of the Upper Gastrointestinal Tract with Colonic Self-Expandable Metal Stents. GE Port J Gastroenterol 24(4):169–175
Wu G, Yin M, Zhao YS et al (2017) Novel esophageal stent for treatment of cervical anastomotic leakage after esophagectomy. Surg Endosc 31(12):5024–5031
Zhang Y, Yao L, Xu M et al (2017) Treatment of leakage via metallic stents placements after endoscopic full-thickness resection for esophageal and gastroesophageal junction submucosal tumors. Scand J Gastroenterol 52(1):76–80
Emre A, Sertkaya M, Akbulut S et al (2018) Self-expandable metallic stent application for the management of upper gastrointestinal tract disease. Turk J Surg 34(2):101–105
Plum PS, Herbold T, Berlth F, et al. Outcome of Self-Expanding Metal Stents in the Treatment of Anastomotic Leaks After Ivor Lewis Esophagectomy. World J Surg 2018
van Heel NC, Haringsma J, Spaander MC et al (2010) Short-term esophageal stenting in the management of benign perforations. Am J Gastroenterol 105(7):1515–1520
D’Cunha J, Rueth NM, Groth SS, et al. Esophageal stents for anastomotic leaks and perforations. J Thorac Cardiovasc Surg 2011; 142(1):39-46 e1
Freeman RK, Vyverberg A, Ascioti AJ. Esophageal stent placement for the treatment of acute intrathoracic anastomotic leak after esophagectomy. Ann Thorac Surg 2011; 92(1):204-8; discussion 208
Freeman RK, Ascioti AJ, Giannini T, et al. Analysis of unsuccessful esophageal stent placements for esophageal perforation, fistula, or anastomotic leak. Ann Thorac Surg 2012; 94(3):959-64; discussion 964-5
van Boeckel PG, Dua KS, Weusten BL et al (2012) Fully covered self-expandable metal stents (SEMS), partially covered SEMS and self-expandable plastic stents for the treatment of benign esophageal ruptures and anastomotic leaks. BMC Gastroenterol 12:19
El H II, Imperiale TF, Rex DK et al (2014) Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes. Gastrointest Endosc 79(4):589–598
Freeman RK, Ascioti AJ, Dake M, et al. An analysis of esophageal stent placement for persistent leak after the operative repair of intrathoracic esophageal perforations. Ann Thorac Surg 2014; 97(5):1715-9; discussion 1719-20
Freeman RK, Herrera A, Ascioti AJ et al (2015) A propensity-matched comparison of cost and outcomes after esophageal stent placement or primary surgical repair for iatrogenic esophageal perforation. J Thorac Cardiovasc Surg 149(6):1550–1555
Suzuki T, Siddiqui A, Taylor LJ et al (2016) Clinical Outcomes, Efficacy, and Adverse Events in Patients Undergoing Esophageal Stent Placement for Benign Indications: a Large Multicenter Study. J Clin Gastroenterol 50(5):373–378
Ben-David K, Lopes J, Hochwald S et al (2011) Minimally invasive treatment of esophageal perforation using a multidisciplinary treatment algorithm: a case series. Endoscopy 43(2):160–162
Ali JT, Rice RD, David EA et al (2017) Perforated esophageal intervention focus (PERF) study: a multi-center examination of contemporary treatment. Dis Esophagus 30(11):1–8
Thornblade LW, Cheng AM, Wood DE et al (2017) A Nationwide Rise in the Use of Stents for Benign Esophageal Perforation. Ann Thorac Surg 104(1):227–233
Aloreidi K, Patel B, Ridgway T et al (2018) Non-surgical management of Boerhaave’s syndrome: a case series study and review of the literature. Endosc Int Open 6(1):E92–E97
Gelbmann CM, Ratiu NL, Rath HC et al (2004) Use of self-expandable plastic stents for the treatment of esophageal perforations and symptomatic anastomotic leaks. Endoscopy 36(8):695–699
Hunerbein M, Stroszczynski C, Moesta KT et al (2004) Treatment of thoracic anastomotic leaks after esophagectomy with self-expanding plastic stents. Ann Surg 240(5):801–807
Langer FB, Wenzl E, Prager G, et al. Management of postoperative esophageal leaks with the Polyflex self-expanding covered plastic stent. Ann Thorac Surg 2005; 79(2):398-403; discussion 404
Schubert D, Scheidbach H, Kuhn R et al (2005) Endoscopic treatment of thoracic esophageal anastomotic leaks by using silicone-covered, self-expanding polyester stents. Gastrointest Endosc 61(7):891–896
Radecke K, Lang H, Frilling A et al (2006) Successful sealing of benign esophageal leaks after temporary placement of a self-expanding plastic stent without fluoroscopic guidance. Z Gastroenterol 44(10):1031–1038
Freeman RK, Ascioti AJ, Wozniak TC (2007) Postoperative esophageal leak management with the Polyflex esophageal stent. J Thorac Cardiovasc Surg 133(2):333–338
Freeman RK, Van Woerkom JM, Ascioti AJ. Esophageal stent placement for the treatment of iatrogenic intrathoracic esophageal perforation. Ann Thorac Surg 2007; 83(6):2003-7; discussion 2007-8
Kiev J, Amendola M, Bouhaidar D et al (2007) A management algorithm for esophageal perforation. Am J Surg 194(1):103–106
Pennathur A, Chang AC, McGrath KM, et al. Polyflex expandable stents in the treatment of esophageal disease: initial experience. Ann Thorac Surg 2008; 85(6):1968-72; discussion 1973
Yano F, El Sherif A, Filipi CJ et al (2008) Use of temporary esophageal stent in management of perforations after benign esophageal surgery. Surg Laparosc Endosc Percutan Tech 18(3):283–285
Freeman RK, Van Woerkom JM, Vyverberg A et al (2009) Esophageal stent placement for the treatment of spontaneous esophageal perforations. Ann Thorac Surg 88(1):194–198
Fernandez A, Vila JJ, Vazquez S, et al. Self-expanding plastic stents for the treatment of post-operative esophago-jejuno anastomosis leak. A case series study. Rev Esp Enferm Dig 2010; 102(12):704-10
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Kamarajah, S.K., Bundred, J., Spence, G. et al. Critical Appraisal of the Impact of Oesophageal Stents in the Management of Oesophageal Anastomotic Leaks and Benign Oesophageal Perforations: An Updated Systematic Review. World J Surg 44, 1173–1189 (2020). https://doi.org/10.1007/s00268-019-05259-6
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DOI: https://doi.org/10.1007/s00268-019-05259-6