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The Predictive Value of Pulse Wave Velocity for Anastomotic Leakage After Colorectal Surgery

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Abstract

Background

Arterial perfusion defects are a risk factor for anastomotic leakage (AL) following colorectal surgery. Measuring arterial stiffness using pulse wave velocity (PWV) is known to reflect the performance of the arterial network. The objective of this study was to assess the predictive value of PWV for AL after colorectal surgery.

Methods

A prospective monocentric study was conducted on all consecutive patients who underwent colorectal surgery scheduled between March 1, 2016 and May 1, 2017. Patients were divided into two groups according to the PWV which was measured preoperatively using the pOpmètre® device: PWV+ (PWV > 10 m/s) and PWV− (PWV ≤ 10 m/s). We then compared the PWV+ and PWV− groups. The primary endpoint was the AL rate.

Results

A total of 96 patients were studied, including 60 in the PWV− group and 36 in the PWV+ group. Patients in the PWV+ group were more at risk of presenting with AL than those in the PWV− group (6.25 vs 0%) (p = 0.002). There was no difference in immediate postoperative complications between the two groups apart from the length of hospital stay. PWV predicted the appearance of AL with a sensitivity of and a negative predictive value of 100%.

Conclusion

Measuring PWV could be a used as a predictive examination in the early detection of AL after colorectal surgery.

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Author notes

  1. A. Venara and R. Jaouen have contributed equally to this work.

Authors and Affiliations

  1. Department of Visceral and Endocrine Surgery, CHU Angers, Angers University Hospital, 4 Rue Larrey, 49933, Angers Cedex 9, France

    A. Venara, R. Jaouen, E. Lermite, P. Le Naoures, C. Casa & A. Hamy

  2. Angers Medical University, Angers, France

    A. Venara, R. Jaouen, E. Lermite & A. Hamy

  3. INSERM U1235- TENS, The Enteric Nervous System in Gut and Brain Disorders, Institute of Digestive Tract Disorders, (Institut des maladies de l’appareil digestif), 1 Rue Gaston Veil 44035, Nantes, France

    A. Venara & E. Duchalais

  4. Department of Visceral and Endocrine Surgery, Nantes University Hospital, 1 Place Alexis Ricordeau, 44000, Nantes, France

    E. Mirallié & E. Duchalais

Authors
  1. A. Venara
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  2. R. Jaouen
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  3. E. Lermite
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  4. P. Le Naoures
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  7. E. Duchalais
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Contributions

Author’s contribution

VA: conception, design, analysis and interpretation of data, manuscript author, provided feedback on the manuscript, drafted the article, and revised it critically with regard to important intellectual content. Final approval of the version to be published. JR: conception, design, analysis and interpretation of data, manuscript author, provided feedback on the manuscript, drafted the article, and revised it critically with regard to important intellectual content. Final approval of the version to be published. LE: provided care for study patients, provided feedback on the manuscript, drafted the article, and revised it critically regarding important intellectual content. Final approval of the version to be published. LNP: provided care for study patients, provided feedback on the manuscript, drafted the article, and revised it critically regarding important intellectual content. Final approval of the version to be published. CC: provided care for study patients, provided feedback on the manuscript, drafted the article, and revised it critically with regard to important intellectual content. Final approval of the version to be published. ME: methodology, statistical analysis and interpretation, provided feedback on the manuscript. Final approval of the version to be published. DE: provided care for study patients, provided feedback on the manuscript, drafted the article, and revised it critically regarding important intellectual content. Final approval of the version to be published. HA: conception, design, analysis and interpretation of data, manuscript author, provided feedback on the manuscript, drafted the article, and revised it critically with regard to important intellectual content. Final approval of the version to be published.

Corresponding author

Correspondence to A. Venara.

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The authors declare no conflicts of interest associated with this study.

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Venara, A., Jaouen, R., Lermite, E. et al. The Predictive Value of Pulse Wave Velocity for Anastomotic Leakage After Colorectal Surgery. World J Surg 43, 252–259 (2019). https://doi.org/10.1007/s00268-018-4757-9

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  • DOI: https://doi.org/10.1007/s00268-018-4757-9

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