World Journal of Surgery

, Volume 42, Issue 11, pp 3463–3473 | Cite as

Enhanced Recovery After Surgery Programs for Laparoscopic Abdominal Surgery: A Systematic Review and Meta-analysis

  • Zhengyan LiEmail author
  • Qingchuan ZhaoEmail author
  • Bin Bai
  • Gang Ji
  • Yezhou Liu
Scientific Review



Enhanced recovery after surgery (ERAS) protocols or laparoscopic technique has been applied in various surgical procedures. However, the clinical efficacy of combination of the two methods still remains unclear. Thus, our aim was to assess the role of ERAS protocols in laparoscopic abdominal surgery.


We performed a systematic literature search in various databases from January 1990 to October 2017. The results were analyzed according to predefined criteria.


In the present meta-analysis, the outcomes of 34 comparative studies (15 randomized controlled studies and 19 non-randomized controlled studies) enrolling 3615 patients (1749 in the ERAS group and 1866 in the control group) were pooled. ERAS group was associated with shorter hospital stay (WMD − 2.37 days; 95% CI − 3.00 to − 1.73; P 0.000) and earlier time to first flatus (WMD − 0.63 days; 95% CI − 0.90 to − 0.36; P 0.000). Meanwhile, lower overall postoperative complication rate (OR 0.62; 95% CI 0.51–0.76; P 0.000) and less hospital cost (WMD 801.52 US dollar; 95% CI − 918.15 to − 684.89; P 0.000) were observed in ERAS group. Similar readmission rate (OR 0.73, 95% CI 0.52–1.03, P 0.070) and perioperative mortality (OR 1.33; 95% CI 0.53–3.34; P 0.549) were found between the two groups.


ERAS protocol for laparoscopic abdominal surgery is safe and effective. ERAS combined with laparoscopic technique is associated with faster postoperative recovery without increasing readmission rate and perioperative mortality.


Authors’ contributions

Zhengyan Li and Qingchuan Zhao performed the experiment conception and design. Zhengyan Li and Bin Bai performed the research and retrieved the data. Zhengyan Li, Gang Ji, and Yezhou Liu performed the data analysis. Zhengyan Li did the paper writing. All authors read and approved the final manuscript.


This study was supported by the National Key Basic Research Program of China (No. 2014CBA02002).

Compliance with ethical standards

Conflict of interest

Zhengyan Li, Qingchuan Zhao, Bin Bai, Gang Ji, and Yezhou Liu have no conflicts of interest or financial ties to disclose.

Supplementary material

268_2018_4656_MOESM1_ESM.docx (224 kb)
Supplementary material 1 (DOCX 223 kb)


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Copyright information

© Société Internationale de Chirurgie 2018

Authors and Affiliations

  1. 1.Department of Surgery, Xijing Hospital of Digestive DiseasesThe Fourth Military Medical UniversityXianChina

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