Predicted Coronary Heart Disease Risk Decreases in Obese Patients After Laparoscopic Sleeve Gastrectomy
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To assess the reduction of 6 and 12 months postoperatively of Framingham risk score in morbidly obese patients with laparoscopic sleeve gastrectomy (LSG).
Material and methods
In total, 870 morbid obesity patients received LSG in Taipei Medical University Hospital from June 2007 to June 2014 were retrospectively studied preoperatively, 6 and 12 months after surgery. The coronary heart disease risk was calculated using Framingham risk score.
The body mass index in men and women decreased from 43.3 ± 6.9, 39.2 ± 6.0 kg/m2 preoperatively to 32.9 ± 6.7, 31.0 ± 5.2 kg/m2 and to 30.4 ± 5.6 , 28.2 ± 4.7 kg/m2, respectively, at 6 and 12 months after surgery (P < 0.0001). At 6 and 12 months after LSG, there was a marked improvement on lipid profile as well as a significant decline in the prevalence of diabetes mellitus, systemic hypertension, and smoking. The Framingham risk score in men and women reduced from 3.2 ± 5.7, 6.1 ± 5.7 preoperatively to 1.4 ± 5.9, 3.3 ± 5.9 and 0.1 ± 6.2, 2.8 ± 6.1, respectively, at 6 and 12 months after surgery (P < 0.0001).
Laparoscopic sleeve gastrectomy is efficient not only in the reduction of obesity and its related comorbidities but also in decreasing the long-term coronary event risk. Early intervention for the high-risk group is strongly recommended.
Compliance with ethical standards
Conflict of interest
All the authors declare that they have no conflict of interest.
- 1.WHO (2015) Obesity and overweightGoogle Scholar
- 2.Health Promotion Administration (2014) Ministry of Health and Welfare. Annual ReportGoogle Scholar
- 3.Hess DS, Hess DW (1998) Biliopancreatic diversion with a duodenal switch. Obes Surg 8(267–28):2Google Scholar
- 4.Cottam D, Qureshi FG, Mattar SG et al (2006) Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc 20(859–86):3Google Scholar
- 7.Deitel M, Gagner M, Erickson AL et al (2011) Third International summit: current status of sleeve gastrectomy. Surg Obes Relat Dis 7(749–75):9Google Scholar
- 10.Vest AR, Heneghan HM, Agarwal S et al (2012) Bariatric surgery and cardiovascular outcomes: a systematic review. Heart 98(1763–177):7Google Scholar
- 14.Galassi A, Reynolds K, He J (2006) Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 119(812–81):9Google Scholar
- 15.Gami AS, Witt BJ, Howard DE et al (2007) Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 49(403–41):4Google Scholar
- 20.Wilson PW, D’Agostino RB, Levy D et al (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97(1837–184):7Google Scholar
- 21.National Cholesterol Education Program Expert Panel on Detection E, Treatment of High Blood Cholesterol in A Third Report of the National Cholesterol Education Program (NCEP) (2002) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106:3143–3421CrossRefGoogle Scholar
- 22.D’Agostino RB Sr, Vasan RS, Pencina MJ et al (2008) General cardiovascular risk profile for use in primary care: the framingham heart study. Circulation 117(743–75):3Google Scholar
- 24.Gutierrez-Blanco D, Funes-Romero D, Madiraju S et al (2017) Reduction of Framingham BMI score after rapid weight loss in severely obese subjects undergoing sleeve gastrectomy: a single institution experience. Surg Endosc 1:1–7Google Scholar
- 26.Brethauer SA, Hammel JP, Schauer PR (2009) Systematic review of sleeve gastrectomy as staging and primary bariatric procedure. Surg Obes Relat Dis 5(469–47):5Google Scholar
- 27.Puzziferri N, Nakonezny PA, Livingston EH et al (2008) Variations of weight loss following gastric bypass and gastric band. Ann Surg 248(233–24):2Google Scholar
- 28.Heneghan HM, Meron-Eldar S, Brethauer SA et al (2011) Effect of bariatric surgery on cardiovascular risk profile. Am J Cardiol 108(1499–150):7Google Scholar
- 29.Iancu M, Copaescu C, Serban M et al (2013) Laparoscopic sleeve gastrectomy reduces the predicted coronary heart disease risk and the vascular age in obese subjects. Chirurgia 108(659–66):5Google Scholar
- 30.Schauer PR, Kashyap SR, Wolski K et al (2012) Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med 366(1567–157):6Google Scholar
- 32.Batsis JA, Romero-Corral A, Collazo-Clavell ML et al (2007) Effect of weight loss on predicted cardiovascular risk: change in cardiac risk after bariatric surgery. Obesity (Silver Spring) 15(772–78):4Google Scholar
- 33.Vogel JA, Franklin BA, Zalesin KC et al (2007) Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery. Am J Cardiol 99(222–22):6Google Scholar