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Postoperative Albumin–Bilirubin Grade Change Predicts the Prognosis of Patients with Hepatitis B-Related Hepatocellular Carcinoma Within the Milan Criteria

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Abstract

Objective

Albumin–bilirubin (ALBI) grade has been validated as a simple, evidence-based, and objective prognostic tool for patients with hepatocellular carcinoma (HCC). However, minimal information is available concerning postoperative ALBI grade changes in HCC. This study aimed to investigate the prognostic value of postoperative ALBI grade changes in patients with hepatitis B virus (HBV)-related HCC within the Milan criteria after liver resection.

Methods

Patients with HBV-related HCC within the Milan criteria who underwent liver resection between 2010 and 2016 at West China Hospital were reviewed (N = 258). A change in ALBI grade was defined as first postoperative month ALBI grade–preoperative ALBI grade. If the value was >0, postoperative worsening of ALBI grade was considered; otherwise, stable ALBI grade was considered. Cox proportional hazard regression analyses were used to determine the factors that influence recurrence and survival.

Results

During the follow-up, 130 patients experienced recurrence and 47 patients died. Multivariate analyses revealed that postoperative worsening of ALBI grade (HR 1.541, 95% CI 1.025–2.318, P = 0.038), microvascular invasion (MVI, HR 1.802, 95% CI 1.205–2.695, P = 0.004), and multiple tumors (HR 1.676, 95% CI 1.075–2.615, P = 0.023) were associated with postoperative recurrence, whereas MVI (HR 2.737, 95% CI 1.475–5.080, P = 0.001), postoperative worsening of ALBI grade (HR 2.268, 95% CI 1.227–4.189, P = 0.009), high alpha-fetoprotein level (HR 2.055, 95% CI 1.136–3.716, P = 0.017), and transfusion (HR 2.597, 95% CI 1.395–4.834, P = 0.003) negatively influenced long-term survival. Patients with postoperative worsening of ALBI grade exhibited increased incidence of recurrence and worse long-term survival.

Conclusion

Postoperative worsening of ALBI grade was associated with increased recurrence and poorer overall survival for patients with HBV-related HCC within the Milan criteria. We should pay attention to liver function changes in HCC patients after liver resection.

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Abbreviations

AFP:

Alpha-fetoprotein

ALBI:

Albumin–bilirubin grade

HBV:

Hepatitis B virus

HCC:

Hepatocellular carcinoma

MVI:

Microvascular invasion

NLR:

Neutrophil to lymphocyte rate

OS:

Overall survival

RFS:

Recurrence-free survival

TNM:

Tumor-node-metastasis

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Acknowledgement

This study was supported by Grants from Science and Technological Supports Project of Sichuan Province (2016SZ0025 and 2015SZ0049) as well as Health and Family Planning Commission of Sichuan Province (17PJ393).

Author contributions

CL and TFW proposed this study. CL, WP, XYZ, LNY, BL, JYY, WTW, and MQX collected the data. CL and XYZ analyzed the data.

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Authors and Affiliations

  1. Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China

    Chuan Li, Xiao-Yun Zhang, Wei Peng, Tian-Fu Wen, Lu-Nan Yan, Bo Li, Jia-Yin Yang, Wen-Tao Wang & Ming-Qing Xu

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  1. Chuan Li
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Correspondence to Tian-Fu Wen.

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Li, C., Zhang, XY., Peng, W. et al. Postoperative Albumin–Bilirubin Grade Change Predicts the Prognosis of Patients with Hepatitis B-Related Hepatocellular Carcinoma Within the Milan Criteria. World J Surg 42, 1841–1847 (2018). https://doi.org/10.1007/s00268-017-4355-2

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  • DOI: https://doi.org/10.1007/s00268-017-4355-2

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