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Margin Width of Resected Lepidic Lung Cancer Does Not Affect Recurrence After Sublobar Resection

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Abstract

Background

A sufficient resection margin is required for the sublobar resection of lung cancers. However, the width of the resection margin may not be important in lepidic adenocarcinoma, because such tumors are non- or minimally invasive. The purpose of this study was to determine the effect of resection margin width on the outcome of patients with lepidic-dominant adenocarcinoma after sublobar resection.

Methods

This study included 133 patients with small (≤2 cm), clinical N0M0 lung cancer who underwent sublobar resection with curative intent. The patients were divided into 4 groups: Group A, lepidic tumor with margin/tumor ratio <1; Group B, lepidic tumor with margin/tumor ratio ≥1; Group C, non-lepidic tumor with margin/tumor ratio <1; Group D, non-lepidic tumor with margin/tumor ratio ≥1. The clinicopathological features and survival outcomes between Group A and B patients, and between Group C and D patients were compared.

Results

The 5-year recurrence-free survival (RFS) rates of Group A and B patients were both 100%. The 5-year RFS rates of Group C and D patients were 49.9 and 97.1%, respectively (p = 0.009). By multivariate analysis, the margin/tumor ratio was a significant independent factor for recurrence in patients with non-lepidic tumors (hazard ratio = 0.157, 95% confidence interval 0.027–0.898; p = 0.037).

Conclusions

Tumor recurrence after sublobar resection is not associated with short resection margins in patients with lepidic tumors. However, a short resection margin is a significant risk factor for recurrence in patients with non-lepidic tumors.

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Acknowledgements

This research was not supported by outside funds.

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea

    Youngkyu Moon & Jae Kil Park

  2. Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Kyo Young Lee

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  1. Youngkyu Moon
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  2. Kyo Young Lee
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Correspondence to Youngkyu Moon.

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Moon, Y., Lee, K.Y. & Park, J.K. Margin Width of Resected Lepidic Lung Cancer Does Not Affect Recurrence After Sublobar Resection. World J Surg 42, 1449–1457 (2018). https://doi.org/10.1007/s00268-017-4291-1

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