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The Prognostic Impact of Controlling Nutritional Status (CONUT) in Intrahepatic Cholangiocarcinoma Following Curative Hepatectomy: A Retrospective Single Institution Study

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Abstract

Background

Several studies have examined controlling nutritional status (CONUT), which is one of the useful biomarkers for predicting patients’ prognosis following cancer treatment. The aim of this study was to evaluate the value of CONUT as a postoperative prognostic marker in patients with intrahepatic cholangiocarcinoma (ICC) following curative hepatectomy.

Methods

We retrospectively analyzed 71 patients who underwent curative hepatectomy for ICC between May 2002 and November 2016. Patients were divided into two groups according to their preoperative CONUT score (i.e., CONUT ≧ 2 or CONUT < 2).

Results

The number of patients assigned to the normal, mild, moderate, or severe malnutrition groups was 40, 28, two, and one, respectively. The high CONUT group (CONUT ≧ 2) consisted of 31 patients (43.7%) and had a poor prognosis with regard to overall survival (OS) (p = 0.0149). A high CONUT score is also identified as one of the independent predictors of poor prognosis in OS (hazard ratio 3.02; 95% confidence interval 1.4–6.8; p = 0.007). However, in the current study, a high CONUT score was not associated with postoperative complications (Clavien–Dindo classification ≧ III or more).

Conclusions

CONUT may be useful for the preoperative assessment of prognosis in patients with ICC who have undergone curative hepatectomy.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan

    Tatsunori Miyata, Yo-ichi Yamashita, Takaaki Higashi, Katsunobu Taki, Daisuke Izumi, Keisuke Kosumi, Ryuma Tokunaga, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto & Hideo Baba

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  1. Tatsunori Miyata
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  2. Yo-ichi Yamashita
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Corresponding author

Correspondence to Hideo Baba.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Use of the clinical data in this study was approved by the human ethics review committee of the graduate school of medicine, Kumamoto University.

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Supplementary material 1 (DOCX 359 kb)

268_2017_4214_MOESM2_ESM.tiff

Figure shows relapse-free survival and overall survival in patients with ICC after curative hepatectomy according to NLR (a, b), PLR (c, d), mGPS (e, f), and PNI (g, h). There is no significant difference between the two groups with respect to any of the biomarkers in this figure. (TIFF 3565 kb)

268_2017_4214_MOESM3_ESM.tiff

Figure shows the relation between CONUT score and NLR. CONUT score and NLR recognized a significant positive correlation (r = 0.494, p = 0.0017). (TIFF 16352 kb)

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Miyata, T., Yamashita, Yi., Higashi, T. et al. The Prognostic Impact of Controlling Nutritional Status (CONUT) in Intrahepatic Cholangiocarcinoma Following Curative Hepatectomy: A Retrospective Single Institution Study. World J Surg 42, 1085–1091 (2018). https://doi.org/10.1007/s00268-017-4214-1

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