Abstract
Background
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is pathologically classified as non-small-cell lung cancer (NSCLC), but its clinical behavior is more aggressive than other types of NSCLC. Accordingly, the optimal treatment strategy for LCNEC, including the indication of adjuvant treatment, remains controversial.
Methods
A retrospective review of 139 patients who underwent curative-intent surgery for LCNEC was performed to investigate clinicopathologic features and survival outcomes and to evaluate whether adjuvant treatment affected survival outcomes.
Results
The mean patient age was 64 years (126 men, 90.6%). Operative procedures included 111 lobectomies (79.8%), 12 pneumonectomies (8.6%), and 2 sublobar resections. Pathologic stage was IA in 31 (22%), IB in 36 (26%), IIA in 34 (24%), IIB in 9 (6%), IIIA in 19 (14%), IIIB in 2 (1.4%), and IV in 4 patients (2.9%). Postoperatively, 50 patients (36%) received adjuvant treatment. The median follow-up duration was 33 months. The 5-year overall survival (OS) rate was 53%, and 5-year disease-free survival (DFS) rate was 39%. In patients with pathologic stage I, there was no significant difference in either OS or DFS according to the addition of adjuvant treatment. However, in patients with pathologic stage II or higher, patients who underwent adjuvant treatment showed significantly better OS (p = 0.023) and DFS (p = 0.038).
Conclusions
Our findings showed that patients who underwent curative-intent surgery for LCNEC benefitted from the use of adjuvant treatment especially in pathologic stage II or higher.
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References
Travis WD (2010) Advances in neuroendocrine lung tumors. Ann Oncol 7:65–71
Asamura H, Kameya T, MAtsuno Y et al (2006) Neuroendocrine neoplasms of the lung: a prognostic spectrum. J Clin Oncol 24:70–76
Fernandez FG, Battafarano RJ (2006) Large-cell neuroendocrine carcinoma of the lung. Cancer Control 13:270–275
Iyoda A, Jiang SX, Travis WD et al (2013) Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. Mol Clin Oncol 1:437–443
Gollard R, Jhatakia S, Elliott M et al (2010) Large cell/neuroendocrine carcinoma. Lung Cancer 69:13–18
Battafarano RJ, Fernandez FG, Ritter J et al (2005) Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer. J Thorac Cardiovasc Surg 130:166–172
Doddoli C, Barlesi F, Chetaille B et al (2004) Large cell neuroendocrine carcinoma of the lung: an aggressive disease potentially treatable with surgery. Ann Thorac Surg 77:1168–1172
Iyoda A, Hiroshima K, Nakatani Y et al (2007) Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. Ann Thorac Surg 84:702–707
Kumar P, Herndon J 2nd, Langer M et al (1996) Pattern of disease failure after trimodality therapy of nonsmall cell lung carcinoma pathologic stage IIIA (N2). Analysis of Cancer and Leukemia Group B Protocol 8935. Cancer 77:2393–2399
Williams CD, Gajra A, Ganti AK et al (2014) Use and impact of adjuvant chemotherapy in patients with resected non-small cell lung cancer. Cancer 120:1939–1947
Howington JA, Blum MG, Chang AC et al (2013) Treatment of stage I and II non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143:278–313
Saji H, Tsuboi M, Matsubayashi J et al (2010) Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapy. Anticancer Drugs 21:89–93
Sarkaria IS, Iyoda A, Roh MS et al (2011) Neoadjuvant and adjuvant chemotherapy in resected pulmonary large cell neuroendocrine carcinoma: a single institution experience. Ann Thorac Surg 92:1180–1186
Travis WD, Brambilla E, Müller-Hermelink HK et al (2004) Pathology and genetics: tumors of the lung, pleura, thymus and heart. IARC, Lyon
Edge S, Byrd DR, Compton CC et al (2009) AJCC cancer staging manual, 7th edn. Springer, New York
Paci M, Cavazza A, Annessi V et al (2004) Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study. Ann Thorac Surg 77:1163–1167
Veronesi G, Morandi U, Alloisio M et al (2006) Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases. Lung Cancer 53:111–115
Iyoda A, Hiroshima K, Moriya Y et al (2009) Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. J Thorac Cardiovasc Surg 138:446–453
Iyoda A, Hiroshima K, Moriya Y et al (2006) Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non small cell carcinoma. J Thorac Cardiovasc Surg 132:312–315
Dresler CM, Ritter JH, Patterson GA et al (1997) Clinical-pathologic analysis of 40 patients with large cell neuroendocrine carcinoma of the lung. Ann Thorac Surg 63:180–185
Douillard JY, Rosell R, De Lena M et al (2006) Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer(Adjuvant Navelbine International Trialist Association[ANITA]): a randomized controlled trial. Lancet Oncol 7:719–727
Butts CA, Ding K, Seymour L et al (2010) Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10. J Clin Oncol 28:29–34
Ettinger DS, Akerley W, Borghaei H et al (2013) Non-small cell lung cancer, version2. 2013. J Natl Compr Canc Netw 11:645–653
Roesel C, Terjung S, Weinreich G et al (2016) A single-institution analysis of the surgical management of pulmonary large cell neuroendocrine carcinomas. Ann Thorac Surg 101:1909–1914
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Kim, K.W., Kim, H.K., Kim, J. et al. Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. World J Surg 41, 1820–1827 (2017). https://doi.org/10.1007/s00268-017-3908-8
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DOI: https://doi.org/10.1007/s00268-017-3908-8