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Impact of the Level of Anastomosis on Reflux Esophagitis Following Esophagectomy with Gastric Tube Reconstruction

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Abstract

Background

Among patients who undergo gastric tube reconstruction after esophagectomy, it is generally accepted that the incidence of reflux esophagitis (RE) is significantly lower in patients with neck anastomosis than in those with intrathoracic anastomosis. However, the true impact of the level of anastomosis on RE currently remains unclear.

Methods

We examined 53 patients with thoracic esophageal cancer underwent radical esophagectomy with gastric tube reconstruction and neck anastomosis. The level of anastomosis was assessed by measuring the distance from the sternal notch to the stapled ring by computed tomography. The relative level of anastomosis was calculated by the distance from the sternal notch to the most caudal side of the stapled ring (mm)/height (cm).

Results

The relative level of anastomosis in 30 (56.6%) patients showed <0, which indicated that anastomosis in these patients was located at a lower level than the sternal notch. The mean relative level of anastomosis was significantly lower in patients with RE (grade A to D) than in those without RE (grade N) (−0.062 vs. −0.012 mm/cm, respectively; p = 0.043). RE was more severe with a lower relative level of anastomosis (p for trends = 0.044).

Conclusions

The level of anastomosis in patients with gastric tube reconstruction following esophagectomy was associated with the incidence of RE. The displacement of anastomosis into the thoracic cavity was detected in approximately half of the patients with neck anastomosis. RE was more severe with a lower level of anastomosis, even in patients with neck anastomosis.

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Author’s contribution

Study conception and design: MS, acquisition of data: TY, YK, HH, KH, analysis and interpretation of data: MS, MS, TM, TY, drafting of manuscript: MS, critical revision: HK.

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Authors and Affiliations

  1. Department of General Surgical Science, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Tomonori Yoshida, Yuji Kumakura, Hiroaki Honjo, Keigo Hara & Hiroyuki Kuwano

  2. Department of Molecular Pharmacology and Oncology, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Takehiko Yokobori

Authors
  1. Makoto Sakai
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  2. Makoto Sohda
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  3. Tatsuya Miyazaki
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  4. Tomonori Yoshida
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  5. Yuji Kumakura
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  6. Hiroaki Honjo
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  7. Keigo Hara
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  9. Hiroyuki Kuwano
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Correspondence to Makoto Sakai.

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Sakai, M., Sohda, M., Miyazaki, T. et al. Impact of the Level of Anastomosis on Reflux Esophagitis Following Esophagectomy with Gastric Tube Reconstruction. World J Surg 41, 804–809 (2017). https://doi.org/10.1007/s00268-016-3786-5

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  • DOI: https://doi.org/10.1007/s00268-016-3786-5

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