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Downregulation of miR-138 as a Contributing Mechanism to Lcn-2 Overexpression in Colorectal Cancer with Liver Metastasis

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References

  1. Maier HT, Aigner F, Trenkwalder B, Zitt M, Vallant N, Perathoner A et al (2014) Up-regulation of neutrophil gelatinase-associated lipocalin in colorectal cancer predicts poor patient survival. World J Surg 38(8):2160–2167. doi:10.1007/s00268-014-2499-x

    Article  PubMed  Google Scholar 

  2. Sun Y, Yokoi K, Li H, Gao J, Hu L, Liu B et al (2011) NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models. Clin Cancer Res 17(13):4331–4340. doi:10.1158/1078-0432.CCR-11-0226

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Martí J, Fuster J, Solà AM, Hotter G, Molina R, Pelegrina A et al (2013) Prognostic value of serum neutrophil gelatinase-associated lipocalin in metastatic and nonmetastatic colorectal cancer. World J Surg 37(5):1103–1109. doi:10.1007/s00268-013-1930-z

    Article  PubMed  Google Scholar 

  4. Lee YC, Tzeng WF, Chiou TJ, Chu ST (2012) MicroRNA-138 suppresses neutrophil gelatinase-associated lipocalin expression and inhibits tumorigenicity. PLoS One 7(12):e52979. doi:10.1371/journal.pone.0052979

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Long L, Huang G, Zhu H, Guo Y, Liu Y, Huo J (2013) Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2. J Transl Med 11:275. doi:10.1186/1479-5876-11-275

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgements

PI12/01552 and PI13/02609 grants from “Instituto de Salud Carlos III FEDER” and S2010/BMD2344, PT13/0010/0012, and RD12/0036/0051 are acknowledged. R. Manso and P. González-Alonso are supported by “Fundación Conchita Rábago de Jiménez Díaz.”

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Authors and Affiliations

  1. Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital “Fundacion Jimenez Diaz”, Avda. Reyes Católicos-2, 28040, Madrid, Spain

    Ion Cristóbal, Blanca Torrejón & Jesús García-Foncillas

  2. Pathology Department, IIS-Fundacion Jimenez Diaz-UAM, University Hospital “Fundacion Jimenez Diaz”, 28040, Madrid, Spain

    Paula González-Alonso, Rebeca Manso & Federico Rojo

Authors
  1. Ion Cristóbal
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  2. Blanca Torrejón
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  3. Paula González-Alonso
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  4. Rebeca Manso
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  5. Federico Rojo
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  6. Jesús García-Foncillas
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Corresponding author

Correspondence to Ion Cristóbal.

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Cristóbal, I., Torrejón, B., González-Alonso, P. et al. Downregulation of miR-138 as a Contributing Mechanism to Lcn-2 Overexpression in Colorectal Cancer with Liver Metastasis. World J Surg 40, 1021–1022 (2016). https://doi.org/10.1007/s00268-015-3241-z

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  • DOI: https://doi.org/10.1007/s00268-015-3241-z

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