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Preoperative Sequential Portal and Hepatic Vein Embolization in Patients with Hepatobiliary Malignancy

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Abstract

Background

Preoperative portal vein embolization (PVE) induces shrinkage of the embolized lobe and compensatory regeneration in the non-embolized lobe, but does not always induce sufficient regeneration of the future remnant liver (FRL). We previously developed preoperative sequential PVE–hepatic vein embolization (HVE), and here we present our experience of treating 42 patients with sequential PVE–HVE.

Methods

During 8-year study period, preoperative PVE–HVE was performed on 42 patients with hepatobiliary malignancies.

Results

Primary diseases were bile duct cancers [perihilar cholangiocarcinoma (n = 33) and diffuse bile duct cancer (n = 1)], hepatocellular carcinomas (n = 4), and intrahepatic tumors [intrahepatic cholangiocarcinoma (n = 3) and gallbladder cancer liver invasion (n = 1)]. These patients demonstrated insufficient FRL regeneration following PVE, thus HVE was performed to induce further regeneration. No PVE–HVE procedure-associated complications occurred. In the bile duct cancer group, FRL volume was 33.9 ± 2.2 % before PVE, 38.4 ± 1.5 % before HVE, 43.7 ± 2.1 % at surgery, and 73.6 ± 8.3 % at 2 weeks after right hepatectomy. The degree of FRL hypertrophy was 13.3 % after PVE, 28.9 % after PHV–HVE, and 117.1 % at 2 weeks after right hepatectomy. All patients except one recovered uneventfully after surgery, and the 3-year patient survival rate was 45.1 %. In the HCC group, transarterial chemoembolization was initially performed and FRL regeneration following PVE–HVE occurred very slowly. Active FRL regeneration occurred in the liver tumor group, but rapid tumor growth was observed in 1 of 4 patients.

Conclusion

The sequential application of HVE following PVE safely and effectively induces further FRL regeneration in non-cirrhotic livers. Further validation using larger patient population and multicenter studies is needed to reliably widen the indications.

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Abbreviations

FRL:

Future remnant liver

HVE:

Hepatic vein embolization

PV:

Portal vein

PVE:

Portal vein embolization

RHV:

Right hepatic vein

MHV:

Middle hepatic vein

TLV:

Total liver volume

TACE:

Transarterial chemoembolization

HCC:

Hepatocellular carcinoma

PHRR:

Parenchymal hepatic resection rate

KGR:

Kinetic growth rate

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Authors and Affiliations

  1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Shin Hwang, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung & Sung-Gyu Lee

  2. Department of Diagnostic Imaging, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Gi-Young Ko & Dong-Il Kwon

  3. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Myung-Hwan Kim & Sung-Koo Lee

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  1. Shin Hwang
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Correspondence to Shin Hwang.

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Hwang, S., Ha, TY., Ko, GY. et al. Preoperative Sequential Portal and Hepatic Vein Embolization in Patients with Hepatobiliary Malignancy. World J Surg 39, 2990–2998 (2015). https://doi.org/10.1007/s00268-015-3194-2

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