Skip to main content

Advertisement

SpringerLink
Log in

Preoperative Hepatitis B Virus DNA Level is a Risk Factor for Postoperative Liver Failure in Patients Who Underwent Partial Hepatectomy for Hepatitis B-Related Hepatocellular Carcinoma

  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Objective

Our objective was to explore the short-term effects of preoperative serum hepatitis B virus DNA level (HBV DNA) on postoperative hepatic function in patients who underwent partial hepatectomy for hepatitis B-related hepatocellular carcinoma (HCC).

Methods

The clinical data of 1,602 patients with hepatitis B-related HCC who underwent partial hepatectomy in our department were retrospectively studied. The patients were divided into three groups according to their preoperative HBV DNA levels: group A <200 IU/mL, group B 200–20,000 IU/mL, and group C >20,000 IU/mL. The rates of postoperative complications, especially the rate of postoperative liver failure, were compared.

Results

There were significant differences among the three groups in the rates of postoperative liver failure. On multivariate logistic regression analysis, a high preoperative HBV DNA level was an independent risk factor for postoperative liver failure.

Conclusions

Preoperative HBV DNA level was a significant risk factor for postoperative hepatic dysfunction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132(7):2557–2576

    Article  CAS  PubMed  Google Scholar 

  2. Bruix J, Sherman M, American Association for the Study of Liver Diseases (2011) Management of hepatocellular carcinoma: an update. Hepatology 53(3):1020–1022

    Article  PubMed Central  PubMed  Google Scholar 

  3. Bruix J, Sherman M, Llovet JM et al (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona 2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35(3):421–430

    Article  CAS  PubMed  Google Scholar 

  4. Pang YY (2002) The Brisbane 2000 terminology of liver anatomy and resections. HPB 2000;2:333–39. HPB (Oxford) 4(2):99 author reply 99–100

    Article  Google Scholar 

  5. Ishak K, Baptista A, Bianchi L et al (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22(6):696–699

    Article  CAS  PubMed  Google Scholar 

  6. Mullen JT, Ribero D, Reddy SK et al (2007) Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy. J Am Coll Surg 204(5):854–862 discussion 862–4

    Article  PubMed  Google Scholar 

  7. Yamashita Y, Hamatsu T, Rikimaru T et al (2001) Bile leakage after hepatic resection. Ann Surg 233(1):45–50

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Lok AS, McMahon BJ (2004) AASLD practice guidelines. Chronic hepatitis B: update of therapeutic guidelines. Rom J Gastroenterol 13(2):150–154

    PubMed  Google Scholar 

  9. Lok AS, McMahon BJ (2007) Chronic hepatitis B. Hepatology 45(2):507–539

    Article  CAS  PubMed  Google Scholar 

  10. Song TJ, Ip EW, Fong Y (2004) Hepatocellular carcinoma: current surgical management. Gastroenterology 127(5 Suppl 1):S248–S260

    Article  PubMed  Google Scholar 

  11. Detroz B, Sugarbaker PH, Knol JA et al (1994) Causes of death in patients undergoing liver surgery. Cancer Treat Res 69:241–257

    Article  CAS  PubMed  Google Scholar 

  12. Jarnagin WR, Gonen M, Fong Y et al (2002) Improvement in perioperative outcome after hepatic resection: analysis of 1, 803 consecutive cases over the past decade. Ann Surg 236(4):397–406 discussion 406–7

    Article  PubMed Central  PubMed  Google Scholar 

  13. Simons JP, Hill JS, Ng SC et al (2009) Perioperative mortality for management of hepatic neoplasm: a simple risk score. Ann Surg 250(6):929–934

    Article  PubMed  Google Scholar 

  14. Schindl MJ, Redhead DN, Fearon KC et al (2005) The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection. Gut 54(2):289–296

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Bertoletti A, Gehring AJ (2006) The immune response during hepatitis B virus infection. J Gen Virol 87(Pt 6):1439–1449

    Article  CAS  PubMed  Google Scholar 

  16. Klenerman P, Hill A (2005) T cells and viral persistence: lessons from diverse infections. Nat Immunol 6(9):873–879

    Article  CAS  PubMed  Google Scholar 

  17. Webster GJ, Reignat S, Maini MK et al (2000) Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 32(5):1117–1124

    Article  CAS  PubMed  Google Scholar 

  18. Trobonjaca Z, Kroger A, Stober D et al (2002) Activating immunity in the liver. II. IFN-beta attenuates NK cell-dependent liver injury triggered by liver NKT cell activation. J Immunol 168(8):3763–3770

    Article  CAS  PubMed  Google Scholar 

  19. Rapicetta M, Ferrari C, Levrero M (2002) Viral determinants and host immune responses in the pathogenesis of HBV infection. J Med Virol 67(3):454–457

    Article  CAS  PubMed  Google Scholar 

  20. Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5(3):215–229

    Article  CAS  PubMed  Google Scholar 

  21. Wieland SF, Chisari FV (2005) Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol 79(15):9369–9380

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Lau JY, Wright TL (1993) Molecular virology and pathogenesis of hepatitis B. Lancet 342(8883):1335–1340

    Article  CAS  PubMed  Google Scholar 

  23. Xie Y, Zhao H, Dai WS et al (2003) HBV DNA level and antigen concentration in evaluating liver damage of patients with chronic hepatitis B. Hepatobiliary Pancreat Dis Int 2(3):418–422

    CAS  PubMed  Google Scholar 

  24. Yeo W, Johnson PJ (2006) Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology 43(2):209–220

    Article  CAS  PubMed  Google Scholar 

  25. Yeo W, Chan PK, Zhong S et al (2000) Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol 62(3):299–307

    Article  CAS  PubMed  Google Scholar 

  26. Yeo W, Lam KC, Zee B et al (2004) Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy. Ann Oncol 15(11):1661–1666

    Article  CAS  PubMed  Google Scholar 

  27. Nagamatsu H, Kumashiro R, Itano S et al (2003) Investigation of associating factors in exacerbation of liver damage after chemotherapy in patients with HBV-related HCC. Hepatol Res 26(4):293–301

    Article  PubMed  Google Scholar 

  28. Zhong S, Yeo W, Schroder C et al (2004) High hepatitis B virus (HBV) DNA viral load is an important risk factor for HBV reactivation in breast cancer patients undergoing cytotoxic chemotherapy. J Viral Hepat 11(1):55–59

    Article  CAS  PubMed  Google Scholar 

  29. Jang JW, Choi JY, Bae SH et al (2006) A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization. Hepatology 43(2):233–240

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

The State Key Project on Infectious Diseases of China: 2008ZX10002-018, 2008ZX10002-025. The Creative Research Group, National Natural Science Foundation of China (30921006, 81081778).

Author information

Authors and Affiliations

  1. The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China

    Gang Huang, Wan Yee Lau, Feng Shen, Ze-ya Pan, Si-yuan Fu, Yun Yang, Wei-ping Zhou & Meng-chao Wu

  2. Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

    Wan Yee Lau

Authors
  1. Gang Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wan Yee Lau
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Feng Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ze-ya Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Si-yuan Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yun Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wei-ping Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Meng-chao Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wei-ping Zhou.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huang, G., Lau, W.Y., Shen, F. et al. Preoperative Hepatitis B Virus DNA Level is a Risk Factor for Postoperative Liver Failure in Patients Who Underwent Partial Hepatectomy for Hepatitis B-Related Hepatocellular Carcinoma. World J Surg 38, 2370–2376 (2014). https://doi.org/10.1007/s00268-014-2546-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-014-2546-7

Keywords

Search

Navigation