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World Journal of Surgery

, Volume 37, Issue 2, pp 356–363 | Cite as

Image and Pathological Changes after Radiofrequency Ablation of Invasive Breast Cancer: A Pilot Study of Nonsurgical Therapy of Early Breast Cancer

  • Yasuteru YoshinagaEmail author
  • Yasuko Enomoto
  • Ritsuko Fujimitsu
  • Mikiko Shimakura
  • Kazuki Nabeshima
  • Akinori Iwasaki
Article

Abstract

Background

The surgical treatment of early breast cancer has proceeded to less invasive approaches with better cosmetic results. The current study was undertaken to evaluate the clinical and pathological findings after radiofrequency ablation (RFA) without resection for a longer period of time.

Method

A total of 14 patients with breast cancer were enrolled. All patients were diagnosed to have invasive ductal carcinoma, and the median breast tumor size was 12 mm (range, 6–20 mm). Six patients received RFA treatment followed by immediate resection and eight patients without resection. The patients without resection were evaluated by ultrasound, MRI, and the pathological findings of a core needle biopsy after RFA. The removed specimens were examined by hematoxylin-eosin (HE) staining and nicotinamide adenine dinucleotide (NADH) diaphorase staining. The median follow-up of the patients was 39.9 months.

Results

NADH staining was necessary to diagnose complete tumor cell death in the tissue for 3 months after RFA. However, HE staining alone could confirm the effect without NADH staining more than 6 months after RFA. Post-RFA, MRI scans clearly demonstrated the area as a complete ablated lesion in all patients without resection. The ablated area detected by MRI or ultrasound became gradually smaller. All patients that underwent RFA with no resection were alive without relapse.

Conclusion

RFA therefore could be an effective alternative to partial mastectomy for early breast cancer. Further research will be necessary to establish the standardization of the indications, as well as the optimal techniques and post treatment evaluation modalities.

Keywords

Breast Cancer Sentinel Node Sentinel Lymph Node Biopsy Early Breast Cancer Core Needle Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirurgie 2012

Authors and Affiliations

  • Yasuteru Yoshinaga
    • 1
    Email author
  • Yasuko Enomoto
    • 1
  • Ritsuko Fujimitsu
    • 2
  • Mikiko Shimakura
    • 2
  • Kazuki Nabeshima
    • 3
  • Akinori Iwasaki
    • 1
  1. 1.Department of General Thoracic, Breast and Pediatric Surgery, School of MedicineFukuoka UniversityFukuokaJapan
  2. 2.Department of Radiology, School of MedicineFukuoka UniversityFukuokaJapan
  3. 3.Department of Pathology, School of MedicineFukuoka UniversityFukuokaJapan

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