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Neonatal Neuroblastoma needs the Aggressive Treatment?

World Journal of Surgery volume 36, pages 2102–2107 (2012)Cite this article

Abstract

Background

Routine antenatal ultrasound scans increased the detection of the neuroblastoma (NB) in neonates. We reviewed the treatment outcome and clinical presentation of neonatal NB.

Methods

We included patients who had pathologically confirmed NB presented within 28 days after birth from January 1999 to December 2010.

Results

There were 17 patients (8 females and 9 males), which consist of 16 % of total NB cases of children in our institution. Nine were followed from prenatal period as an abdominal mass and eight were presented postnatally (5 abdominal distensions, 2 tachypnea, and 1 persistent jaundice). The primary lesion was located in adrenal gland in ten patients, retroperitoneum in four, and posterior mediastinum in three. The tumor size was median 4.1 cm (range, 3–7). The stage of the patients were as follows: stage 1 in six, stage 2 in one, stage 3 in three, stage 4S in five, and stage 4 in two. Six patients were in the low-risk group, seven were intermediate-risk group, and four were high-risk group. Thirteen showed favorable histology among 15 specimens. Five patients (29.4 %) showed MYCN amplification. The median follow-up period was 78.4 months (range, 17.4–138.6). Fifteen of 17 (88.2 %) are alive without evidence of recurrences and two patients of stage 4S with MYCN amplification in high-risk group died.

Conclusions

The overall survival of neonatal NB is 88.2 %, but we observed a high ratio of stage 4 and stage 4S tumors and MYCN amplification. We suggested that early treatment might be better for neonatal NB more than 3 cm in size. Aggressive treatment for neonatal NB could bring more favorable outcome.

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Affiliations

  1. Department of Pediatric Surgery, Inje University Haeundae Paik Hospital, Busan, Korea

    So-Hyun Nam

  2. Department of Pediatric Surgery, University of Ulsan College of Medicine, Asan Medical Center, 388-1, Poognap-dong, Songpa-gu, Seoul, Korea

    Dae Yeon Kim & Seong Chul Kim

  3. Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

    Jong-Jin Seo

Authors
  1. So-Hyun Nam
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  2. Dae Yeon Kim
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  3. Seong Chul Kim
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  4. Jong-Jin Seo
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Correspondence to Dae Yeon Kim.

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Nam, SH., Kim, D.Y., Kim, S.C. et al. Neonatal Neuroblastoma needs the Aggressive Treatment?. World J Surg 36, 2102–2107 (2012). https://doi.org/10.1007/s00268-012-1632-y

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  • DOI: https://doi.org/10.1007/s00268-012-1632-y

Keywords

  • Adrenal Mass
  • Posterior Mediastinum
  • Adrenal Hemorrhage
  • MYCN Amplification
  • Favorable Histology