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Impact of Clinical and Pathohistological Characteristics on the Incidence of Recurrence and Survival in Elderly Patients with Gastric Cancer

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Abstract

Background

Gastric cancer is one of the most frequent malignant tumors worldwide. Despite improvements in diagnostic procedures, as well as the introduction of multimodal treatment strategies, the overall prognosis remains poor. The role of gastric resection in elderly patients with gastric cancer has not been clearly defined as yet. The goal of the present study was to assess whether specific pathohistological features result in different outcomes for younger patients and elderly patients.

Methods

A total of 272 patients with advanced gastric cancer treated surgically in our hospital between 1998 and 2009 were included in the study. Data were analyzed from a prospectively maintained database.

Results

Median overall survival was 84 months in the younger subgroup and 37 months in the elderly subgroup (P = 0.038), whereas local recurrence occurred more frequently in younger patients (33% vs. 23%). We identified positive lymph nodes at the contralateral curvature, perilymphonodular tumor cells, and positive lymph node conglomerates as strong negative prognostic factors. There were few pathohistological characteristics that affected survival and the incidence of tumor recurrence differently in elderly and younger patients. Although only a few elderly patients underwent chemotherapy plus gastric resection (7% vs. 28% of the younger patients), there was a trend toward longer survival for those who received multimodal treatment.

Conclusions

Our results suggest that there is no tumor-related prognostic difference between young and elderly patients that would preclude radical surgery in elderly patients, as long as they are generally fit for surgery.

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Authors and Affiliations

  1. Department of General, Visceral and Vascular Surgery, University of Jena, Erlanger Allee 101, 07740, Jena, Germany

    Yves Dittmar, Falk Rauchfuss, Max Götz, Hubert Scheuerlein, Karin Jandt & Utz Settmacher

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  1. Yves Dittmar
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  2. Falk Rauchfuss
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  3. Max Götz
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  4. Hubert Scheuerlein
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  5. Karin Jandt
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  6. Utz Settmacher
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Correspondence to Yves Dittmar.

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Dittmar, Y., Rauchfuss, F., Götz, M. et al. Impact of Clinical and Pathohistological Characteristics on the Incidence of Recurrence and Survival in Elderly Patients with Gastric Cancer. World J Surg 36, 338–345 (2012). https://doi.org/10.1007/s00268-011-1395-x

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  • DOI: https://doi.org/10.1007/s00268-011-1395-x

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