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Clinical Implication of Serosal Change in Pathologic Subserosa-Limited Gastric Cancer

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Abstract

Background

The aim of this study was to evaluate the clinical implication of serosal change in pathologic subserosa-limited gastric cancer based on a retrospective analysis.

Methods

A total of 285 patients who were diagnosed with pathologically subserosa-limited gastric cancer were included. The patients were divided into two groups: the accordance group, with subserosa-limited cancer without macroscopic serosa change (n = 124); the discordance group, with subserosa-limited cancer showing macroscopic serosal change (n = 161).

Results

Tumor size, number of metastatic lymph nodes, and pathologic N stage were significantly associated with macroscopic serosal change. Serosal change patients presented a higher recurrence rate compared with patients without serosal change (38.0 vs. 20.2% for the 5-year recurrence rate, P = 0.002), and peritoneal seeding presented frequently in serosal-change patients with significance (41.1%). Likewise, the overall survival of serosal-change patients was significantly worse than that for those without serosal change (66.9 vs. 81.4% for the 5-year survival rate, P = 0.002). Serosal change was an independent prognostic factor for overall survival (relative risk 1.784, P = 0.039).

Conclusions

Serosal change in pathologic subserosa-limited gastric cancer is related to poor survival. Therefore, adjuvant chemotherapy should be considered for these patients, and adequate follow-up programs instituted for early detection of peritoneal seeding.

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Acknowledgments

We thank Dr. Jung for designation and assistance on the draft and statistical analyses.

Conflicts of interest

The authors declare that there are no actual or potential conflicts of interest.

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Authors and Affiliations

  1. Department of Surgery, Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul, 137-701, Korea

    Joo Mee Kim, Hun Jung, Jun Suh Lee, Han Hong Lee, Kyo Yung Song, Cho Hyun Park & Myung Hae Jeon

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  1. Joo Mee Kim
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  2. Hun Jung
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  3. Jun Suh Lee
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Correspondence to Myung Hae Jeon.

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Kim, J.M., Jung, H., Lee, J.S. et al. Clinical Implication of Serosal Change in Pathologic Subserosa-Limited Gastric Cancer. World J Surg 36, 355–361 (2012). https://doi.org/10.1007/s00268-011-1334-x

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  • DOI: https://doi.org/10.1007/s00268-011-1334-x

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