Abstract
Background
Despite curative surgery for gastric cancer, many patients die of recurrent cancer. Few studies have investigated the time to recurrence after curative resection for gastric cancer.
Methods
Data were collected prospectively between December 1987 and December 2006. A total of 1,549 patients underwent curative resection of adenocarcinoma of the stomach at Taipei Veterans General Hospital. Among them, 419 patients had recurrence; they were divided into early recurrence (<2 years) and late recurrence (≥2 years). The clinicopathological characteristics, survival time after recurrence, and recurrence patterns were compared between the two groups.
Results
Multivariate analysis showed that stage III gastric cancer patients with early recurrence had larger tumors and more lymph node metastasis than patients with late recurrence, while no difference between early and late recurrence was observed in stage I and II patients. Early recurrence was associated with more distant metastasis than was late recurrence. Patients with advanced TNM stage tended to die within 2 years after recurrence.
Conclusions
Gastric cancer patients with larger tumors and more lymph node metastasis tended to have early recurrence, especially stage III patients. Advanced TNM stage was associated with early cancer death after recurrence.
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References
Nakamura K, Ueyama T, Yao T et al (1992) Pathology and prognosis of gastric carcinoma. Findings in 10,000 patients who underwent primary gastrectomy. Cancer 70:1030–1037
Adachi Y, Oshiro T, Mori M et al (1996) Prediction of early and late recurrence after curative resection for gastric carcinoma. Cancer 77:2445–2448
Shiraishi N, Inomata M, Osawa N et al (2000) Early and late recurrence after gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer 89:255–261
Otsuji E, Kuriu Y, Ichikawa D et al (2004) Time to death and pattern of death in recurrence following curative resection of gastric carcinoma: analysis based on depth of invasion. World J Surg 28:866–869. doi:10.1007/s00268-004-7359-7
Yokota T, Saito T, Teshima S et al (2002) Early and late recurrences after gastrectomy for gastric cancer: a multiple logistic regression analysis. Upsala J Med Sci 107:17–22
Eom BW, Yoon H, Ryu KW et al (2010) Predictors of timing and patterns of recurrence after curative resection for gastric cancer. Dig Surg 27:481–486
Sakuramoto S, Sasako M, Yamaguchi T et al (2007) ACTS-GC Group. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357:1810–1820
Sakar B, Karagol H, Gumus M et al (2004) Timing of death from tumor recurrence after curative gastrectomy for gastric cancer. Am J Clin Oncol 27:205–209
Acknowledgments
This research was supported by the Center of Excellence for Cancer Research at Taipei Veterans General Hospital (DOH100-TD-C-111-007) and the grants from Taipei Veterans General Hospital (99DHA0100632).
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The authors have no financial ties to disclose.
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Chiang, CY., Huang, KH., Fang, WL. et al. Factors Associated with Recurrence Within 2 Years After Curative Surgery for Gastric Adenocarcinoma. World J Surg 35, 2472–2478 (2011). https://doi.org/10.1007/s00268-011-1247-8
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DOI: https://doi.org/10.1007/s00268-011-1247-8