Abstract
Background
The purpose of the study was to determine the incidence of any unplanned reoperation or reintervention procedure after pancreatic resection and to identify the underlying risk factors.
Methods
A total of 189 consecutive pancreatic resections performed from 2001–2008 were searched for any unplanned reoperation, percutaneous drainage, or angiographic reintervention. A retrospective analysis of a prospectively maintained database, including patient characteristics, comorbidities, details of surgery, specific complications, incidence of reoperation/reintervention, and mortality was performed.
Results
Overall rates of reoperation, reintervention, and mortality were 6.3% (12/189), 7.9% (15/189), and 1.6% (3/189), respectively. Four patients underwent reintervention and reoperation, so the combined reoperation/reintervention rate was 12.2% (23/189). Reoperation (P < 0.001) and reintervention (P = 0.002) correlated with mortality. Hemorrhage (relative risk [RR], 58; P = 0.0017) and the combination of hemorrhage and pancreatic fistula (RR, 117; P < 0.0001) were identified as risk factors for unplanned reoperation, hemorrhage (RR, 82; P = 0.005), pancreatic fistula (RR, 42; P < 0.001), and the combination of both complications (RR, 246; P < 0.001) for reoperation and/or reintervention. Other patient- or procedure-related factors did not influence the reoperation and/or reintervention rates significantly.
Conclusions
Pancreatic fistula and hemorrhage are the predominant factors that afford unplanned reoperation/reintervention. Although reporting the incidence of unplanned reoperation will include the most severe postoperative complications, a considerable number of reinterventions are missed. Therefore, in outcome analyses of pancreatic surgery, not only reoperations but also any interventional therapies should be included.
Similar content being viewed by others
References
Birkmeyer JD, Siewers AD, Finlayson EV et al (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346:1128–1137
Nathan H, Cameron JL, Choti MA et al (2009) The volume-outcomes effect in hepato-pancreato-biliary surgery: hospital versus surgeon contributions and specificity of the relationship. J Am Coll Surg 208:528–538
Allareddy V, Ward MM, Allareddy V, Konety BR (2010) Effect of meeting leapfrog volume thresholds on complication rates following complex surgical procedures. Ann Surg 251:377–383
Winter JM, Cameron JL, Campbell KA et al (2006) 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg 10:1199–1211
McPhee JT, Hill JS, Whalen GF et al (2007) Perioperative mortality for pancreatectomy. A national perspective. Ann Surg 246:246–253
Birkmeyer JD, Hamby LS, Birkmeyer CM et al (2001) Is unplanned return to the operating room a useful quality indicator in general surgery? Arch Surg 136:405–410
Ansari MZ, Collopy BT (1966) The risk of an unplanned return to the operating room in Australian hospitals. Aust N Z J Surg 66:10–13
Traverso WL, Shinchi H, Low DE (2004) Useful benchmarks to evaluate outcomes after esophagectomy and pancreaticoduodenectomy. Am J Surg 187:604–608
Glasgow RE, Jackson HH, Neumayer L et al (2007) Pancreatic resection in Veterans Affairs and selected University Medical Centers: results of The Patient Safety in Surgery Study. J Am Coll Surg 204:1252–1260
Standop J, Glowka T, Schmit V et al (2009) Operative re-intervention following pancreatic head resection: indications and outcome. J Gastrointest Surg 13:1503–1509
Limongelli P, Khorsandi SE, Pai M et al (2008) Management of delayed postoperative hemorrhage after pancreatoduodenectomy. Arch Surg 143:1001–1007
Veillette G, Dominguez I, Ferrone C et al (2008) Implications and management of pancreatic fistulas following pancreatoduodenectomy: the Massachusetts General Hospital experience. Arch Surg 143:476–481
Grobmyer ST, Pieracci F, Allen PJ et al (2007) Defining morbidity after pancreaticoduodenectomy: use of a prospective complication grading system. J Am Coll Surg 204:356–364
Suzuki Y, Fujino Y, Ajiki T et al (2005) No mortality among 100 consecutive pancreaticoduodenectomies in a middle-volume center. World J Surg 29:1409–1414. doi:10.1007/s00268-005-0152-4
Wamser P, Stift A, Passler C, Goetzinger P, Sautner T, Jakesz R, Fuegger R (2002) How to pass on expertise: pancreatoduodenectomy at a teaching hospital. World J Surg 26(12):1458–1462. doi:10.1007/s00268-002-5958-8
Sarr MG for The Pancreatic Surgery Group (2003) The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatoduodenectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. J Am Coll Surg 196:556–564
Bassi C, Dervenis CH, Butturini G et al (2005) Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138:8–13
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213
DeOliveira M, Winter JM, Schäfer M et al (2006) Assessment of complications after pancreatic surgery. Ann Surg 244:931–939
Wente MN, Veit JA, Bassi C et al (2007) Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 142:20–25
Sobin LH, Gospodarowicz MK, Wittekind CH (2009) UICC: TNM classification of malignant tumors, 7th edition. Wiley–Blackwell, Oxford
Fröschl U, Sengstbratl M, Huber JU, Függer R (2006) Unplanned reoperation for infection complications: a survey for quality control. Surg Infect 3:263–268
Reid-Lombardo KM, Farnell MB, Crippa S et al (2007) Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1507 patients: a report from the Pancreatic Anastomosis Leak Study Group. J Gastrointest Surg 11:1451–1459
Pratt W, Maithel SK, Vanounou T et al (2006) Postoperative pancreatic fistulas are not equivalent after proximal, distal, and central pancreatectomy. J Gastrointest Surg 10:1265–1279
Pratt WB, Callery MP, Vollmer CM (2008) Risk prediction for development of pancreatic fistula using the ISGPF classification scheme. World J Surg 32:419–428. doi:10.1007/s00268-007-9388-5
Vin Y, Sima C, Getrajdman GI et al (2008) Management and outcomes of postpancreatectomy fistula, leak and abscess: results of 908 patients resected at a single institution between 2000 and 2005. J Am Coll Surg 207:490–498
Strasberg SM, Linehan DC, Clavien PA, Barkun JS (2007) Proposal for definition and severity grading of pancreatic anastomosis failure and pancreatic occlusion failure. Surgery 141:420–426
Fuks D, Piessen G, Huet E et al (2009) Life-threatening postoperative pancreatic fistula (grade C) after pancreaticoduodenectomy: incidence, prognosis, and risk factors. Am J Surg 197:702–709
Bassi C, Molinari E, Malleo G, Crippa S, Butturini G, Salvia R, Talamini G, Pederzoli P (2010) Early versus late drain removal after standard pancreatic resections: results of a prospective randomized trial. Ann Surg 252(2):207–214
Conflict of Interest
The authors declare no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gangl, O., Fröschl, U., Hofer, W. et al. Unplanned Reoperation and Reintervention after Pancreatic Resections: An Analysis of Risk Factors. World J Surg 35, 2306–2314 (2011). https://doi.org/10.1007/s00268-011-1213-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-011-1213-5