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Video-Assisted Bilateral Neck Exploration in Patients with Primary Hyperparathyroidism and Failed Localization Studies

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Abstract

Background

In primary hyperparathyroidism (pHPT) positive preoperative localization studies are accepted as a precondition for applying minimally invasive surgical techniques. Without localization, open bilateral neck exploration (BNE) is considered the standard option. Thepresent study analyzes the feasibility and effectiveness of minimally invasive video-assisted BNE in patients with pHPT and negative or discordant localization studies.

Methods

From a prospective series of 380 minimally invasive video-assisted parathyroidectomies (MIVAP) performed in 367 patients for pHPT (1999–2009), 68 patients (10 male, 58 female; mean age: 58 years) were selected. These patients had failed localization studies and underwent BNE with the MIVAP technique. Operative time, complications, conversions to open technique, and cure rate were determined.

Results

Mean operative time was 52 ± 26 min (range: 20–180 min). MIVAP with BNE was successfully completed in 66 (97%) patients with two conversions to open technique. Recurrent laryngeal nerve palsy occurred in one patient. Biochemical cure was achieved in 67 patients (98.5%), in 65 patients (95.5%) after the first operation and in two more patients by video-assisted re-exploration on the first postoperative day. One patient remained with persistent disease even after repeated open BNE.

Conclusions

In experienced hands, video-assisted BNE with the MIVAP technique, for pHPT and failed localization studies, is feasible, safe, and gives results equivalent to the conventional open technique.

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References

  1. Mollerup CL, Bollerslev J, Blichert-Toft M (1994) Primary hyperparathyroidism: incidence and clinical and biochemical characteristics. A demographic study. Eur J Surg 160:485–489

    CAS  PubMed  Google Scholar 

  2. Rubin MR, Bilezikian JP, McMahon DJ et al (2008) The natural history of primary of primary hyperparathyroidism with or without parathyroid surgery after 15 years. J Clin Endocrinol Metab 93:3462–3470

    Article  CAS  PubMed  Google Scholar 

  3. Mack LA, Pasieka J (2004) Asymptomatic primary hyperparathyroidism: a surgical perspective. Surg Clin North Am 84:803–816

    Article  PubMed  Google Scholar 

  4. Edwards ME, Rotramel A, Beyer T et al (2006) Improvement in the health-related quality-of-life symptoms of hyperparathyroidism is durable on long-term follow-up. Surgery 140:655–663

    Article  CAS  PubMed  Google Scholar 

  5. Walgenbach S, Hommel G, Junginger T (2000) Outcome after surgery for primary hyperparathyroidism: ten-year prospective follow-up study. World J Surg 24:564–569

    Article  CAS  PubMed  Google Scholar 

  6. Mandl F (1926) Therapeutisher versuch bein falls von ostitis fibrosa generalisata mittles. Extirpation eines epithelko¨rperchen tumors. Wien Klin Wochenschr 143:245–284

    Google Scholar 

  7. van Heerden JA, Grant CS (1991) Surgical treatment of primary hyperparathyroidism: an institutional perspective. World J Surg 15:688–692

    Article  PubMed  Google Scholar 

  8. Lumachi F, Zucchetta P, Marzola MC et al (2000) Advantages of combined technetium-99 m-sestamibi scintigraphy and high-resolution ultrasonography in parathyroid localization: comparative study in 91 patients with primary hyperparathyroidism. Eur J Endocrinol 143:755–760

    Article  CAS  PubMed  Google Scholar 

  9. Johnson NA, Tublin ME, Ogilvie JB (2007) Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism. AJR Am J Roentgenol 188:1706–1715

    Article  PubMed  Google Scholar 

  10. Irvin GL III, Dembrow VD, Prudhomme DL (1993) Clinical usefulness of an intraoperative “quick parathyroid hormone” assay. Surgery 114:1019–1023

    PubMed  Google Scholar 

  11. Bergson EJ, Sznyter LA, Dubner S et al (2004) Sestamibi scans and intraoperative parathyroid hormone measurement in the treatment of primary hyperparathyroidism. Arch Otolaryngol Head Neck Surg 130:87–91

    Article  PubMed  Google Scholar 

  12. Lee JA, Inabnet WB III (2005) The surgeon’s armamenterium to surgical treatment of primary hyperparathyroidism. J Surg Oncol 89:130–135

    Article  PubMed  Google Scholar 

  13. Palazzo FF, Delbridge LW (2004) Minimal-access/minimally invasive parathyroidectomy for primary hyperparathyroidism. Surg Clin North Am 84:717–734

    Article  PubMed  Google Scholar 

  14. Miccoli P, Bendinelli C, Berti P et al (1999) Video-assisted versus conventional parathyroidectomy in primary hyperparathyroidism: a prospective randomized study. Surgery 126:1117–1121

    Article  CAS  PubMed  Google Scholar 

  15. Bergenfelz A, Lindlom P, Tibblin S et al (2002) Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomised controlled trial. Ann Surg 236:543–551

    Article  PubMed  Google Scholar 

  16. Russel CF, Dolan SJ, Laird JD (2006) Randomised clinical trial comparing scan-directed unilateral versus bilateral exploration for parathyroidectomy due to solitary adenoma. Br J Surg 93:418–421

    Article  Google Scholar 

  17. Henry JF, Raffaelli M, Iacobone M et al (2001) Video-assisted parathyroidectomy via the lateral approach vs conventional surgery in the treatment of sporadic primary hyperparathyroidism: results of a case-control study. Surg Endosc 15:1116–1119

    Article  CAS  PubMed  Google Scholar 

  18. Tang T, Dolan S, Robinson B et al (2007) Does the surgical approach affect quality of life outcomes?—a comparison of minimally invasive parathyroidectomy with open parathyroidectomy. Int J Surg 5:17–22

    Article  PubMed  Google Scholar 

  19. Sackett WR, Barraclough B, Reeve TS et al (2002) Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy. Arch Surg 137:1055–1059

    Article  PubMed  Google Scholar 

  20. Arici C, Cheah WK, Ituarte PH et al (2001) Can localization studies be used to direct focused parathyroid operations? Surgery 129:720–729

    Article  CAS  PubMed  Google Scholar 

  21. Scheiner JD, Dupuy DE, Monchik JM et al (2001) Pre-operative localization of parathyroid adenomas: a comparison of power and colour Doppler ultrasonography with nuclear medicine scintigraphy. Clin Radiol 56:984–988

    Article  CAS  PubMed  Google Scholar 

  22. Moalem J, Guerrero M, Kebebew E (2009) Bilateral neck exploration in primary hyperparathyroidism—when is it selected and how is it performed. World J Surg 33:2282–2291

    Article  PubMed  Google Scholar 

  23. Chen H, Pruhs Z, Starling JR et al (2005) Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy. Surgery 138:583–587

    Article  PubMed  Google Scholar 

  24. Miccoli P, Berti P, Materazzi G et al (2004) Results of video-assisted Parathyroidectomy: single institution’s six year experience. World J Surg 28:1216–1218

    Article  PubMed  Google Scholar 

  25. Gawande AA, Monchik JM, Abbruzzese TA et al (2006) Reassessment of parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism after 2 preoperative localization studies. Arch Surg 141:381–384 discussion 384

    Article  CAS  PubMed  Google Scholar 

  26. Mihai R, Palazzo FF, Gleeson FV et al (2007) Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism. Br J Surg 94:42–47

    Article  CAS  PubMed  Google Scholar 

  27. Jacobson SR, van Heerden JA, Farley DR et al (2004) Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe. World J Surg 28:1127–1131

    Article  PubMed  Google Scholar 

  28. Gauger PG, Agarwal G, England BG et al (2001) Intraoperative parathyroid hormone monitoring fails to detect double parathyroid adenomas: a 2-institution experience. Surgery 130:1005–1010

    Article  CAS  PubMed  Google Scholar 

  29. Karakousis GC, Han D, Kelz RR et al (2007) Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT). Surgery 142:845–850

    Article  PubMed  Google Scholar 

  30. Phillips IJ, Kurzawinski TR, Honour JW (2005) Potential pitfalls in intraoperative parathyroid hormone measurements during parathyroid surgery. Ann Clin Biochem 42:453–458

    Article  CAS  PubMed  Google Scholar 

  31. Fraker DL, Harsono H, Lewis R (2009) Minimally invasive parathyroidectomy: benefits and requirements of localisation, diagnosis, and intraoperative PTH monitoring. Long term results. World J Surg 33:2256–2265

    Article  PubMed  Google Scholar 

  32. Sebag F, Hubbard JG, Maweja S et al (2003) Negative preoperative localisation studies are highly predictive of multiglandular disease in sporadic primary hyperparathyroidism. Surgery 134:1038–1041

    Article  PubMed  Google Scholar 

  33. Miccoli P, Berti P, Conte M et al (2000) Minimally invasive video-assisted parathyroidectomy: lesson learned from 137 cases. J Am Coll Surg 191:613–618

    Article  CAS  PubMed  Google Scholar 

  34. Cook GJ, Wong JC, Smellie WJ (1998) [11C]Methionine positron emission tomography for patients with persistent or recurrent hyperparathyroidism after surgery. Eur J Endocrinol 139:195–197

    Article  CAS  PubMed  Google Scholar 

  35. Gagner M (1996) Endoscopic parathyroidectomy. Br J Surg 83:875

    Article  CAS  PubMed  Google Scholar 

  36. Ikeda Y, Takami H, Niimi M et al (2002) Endoscopic total parathyroidectomy by the anterior chest approach for renal hyperparathyroidism. Surg Endosc 16:320–322

    Article  CAS  PubMed  Google Scholar 

  37. Henry JF, Defechereux T, Gramatica L et al (1999) Minimally invasive video-assisted parathyroidectomy by lateral approach. Langenbecks Arch Surg 384:298–301

    Article  CAS  PubMed  Google Scholar 

  38. Miccoli P, Bendinelli C, Conte M et al (1998) Endoscopic parathyroidectomy by a gasless approach. J Laparoendosc Adv Surg Tech A 8:189–194

    Article  CAS  PubMed  Google Scholar 

  39. Henry JF, Sebag F, Cherenko M et al (2008) Endoscopic parathyroidectomy: why and when? World J Surg 32:2509–2515

    Article  PubMed  Google Scholar 

  40. Lombardi CP, Raffaelli M, Traini E et al (2009) Video-assisted minimally invasive parathyroidectomy: benefits and long-term results. World J Surg 33:2266–2281

    Article  PubMed  Google Scholar 

  41. Lombardi CP, Raffaelli M, Traini E et al (2008) Advantages of a video-assisted approach to parathyroidectomy. ORL J Otorhinolaryngol Relat Spec 70:313–318

    PubMed  Google Scholar 

  42. Berti P, Materazzi G, Picone A et al (2003) Limits and drawbacks of video-assisted parathyroidectomy. Br J Surg 90:743–747

    Article  CAS  PubMed  Google Scholar 

  43. Henry JF, Sebag F, Tamagnini P et al (2004) Endoscopic parathyroid surgery: results of 365 consecutive procedures. World J Surg 28:1219–1223

    Article  PubMed  Google Scholar 

  44. Arnalsteen LC, Alesina PF, Quiereux JL et al (2002) Long-term results of less than total parathyroidectomy for hyperparathyroidism in multiple endocrine neoplasia type 1. Surgery 132:1119–1125

    Article  PubMed  Google Scholar 

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Correspondence to Pier F. Alesina.

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Alesina, P.F., Singaporewalla, R.M. & Walz, M.K. Video-Assisted Bilateral Neck Exploration in Patients with Primary Hyperparathyroidism and Failed Localization Studies. World J Surg 34, 2344–2349 (2010). https://doi.org/10.1007/s00268-010-0700-4

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