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Significance of Lavage Cytology in Advanced Gastric Cancer Patients

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Abstract

Background

Lavage cytology positive (Cy1) is well known as a poor prognostic factor in advanced gastric cancer patients. However, the optimal therapeutic strategy for patients with Cy1 has not yet been established. The aim of this study was to evaluate the clinical significance of Cy1 for the purpose of establishing a suitable therapeutic strategy.

Methods

The data of 996 consecutive advanced gastric cancer patients who underwent gastrectomy between 1992 and 1998 at the National Cancer Center Hospital were retrospectively studied.

Results

The 2- and 5-year survival rates of the patients who underwent gastrectomy without any other noncurative factors besides Cy1 were 25.3 and 7.8%, respectively. When the analysis was limited to type 4 advanced gastric cancer patients, none of the patients with Cy1 survived for more than 40 months.

Conclusions

The prognosis of gastric cancer patients with Cy1 is very poor. Some patients show long survival after standard gastrectomy with D2 lymph node dissection; however, the prognosis of type 4 gastric cancer patients with Cy1 is so poor that multimodality therapy, including perioperative chemotherapy, is essential.

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Authors and Affiliations

  1. Gastric Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Takeo Fukagawa, Hitoshi Katai, Makoto Saka & Shinji Morita

  2. Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan

    Yuko Sasajima & Hirokazu Taniguchi

  3. Digestive Surgery, Cancer Institute Hospital, Tokyo, Japan

    Takeshi Sano

  4. Digestive Surgery, Hyogo Medical College, Nishinomiya, Hyogo, Japan

    Mitsuru Sasako

Authors
  1. Takeo Fukagawa
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  2. Hitoshi Katai
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  3. Makoto Saka
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  4. Shinji Morita
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  5. Yuko Sasajima
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  6. Hirokazu Taniguchi
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  7. Takeshi Sano
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  8. Mitsuru Sasako
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Corresponding author

Correspondence to Takeo Fukagawa.

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Fukagawa, T., Katai, H., Saka, M. et al. Significance of Lavage Cytology in Advanced Gastric Cancer Patients. World J Surg 34, 563–568 (2010). https://doi.org/10.1007/s00268-009-0355-1

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  • DOI: https://doi.org/10.1007/s00268-009-0355-1

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