World Journal of Surgery

, Volume 34, Issue 4, pp 632–634 | Cite as

Fibrin Sealant: Past, Present, and Future: A Brief Review

  • William D. SpotnitzEmail author



Fibrin sealant is a two-component topical hemostat, sealant, and tissue adhesive consisting of fibrinogen and thrombin that has been used in the United States as a blood bank- or laboratory-derived product since the 1980s and has been commercially available since 1998.


Initially, surgeons employed hospital-based materials because of the lack of availability of a commercially produced agent. At present, there are five U.S. Food and Drug Administration (FDA)-approved forms including products derived from pooled or autologous human plasma as well as bovine plasma. On-label indications include hemostasis, colonic sealing, and skin graft attachment. Recent clinical and experimental uses include tissue or mesh attachment, fistula closure, lymphatic sealing, adhesion prevention, drug delivery, and tissue engineering.


The modern literature on fibrin sealant now exceeds 3000 articles and continues to expand. This brief review presents the history of this material, its present clinical use, and its future applications.


Fibrinogen Fibrin Glue Fibrin Sealant Fistula Closure Colostomy Closure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author thanks Dr. Eric Rose for his interest in fibrin sealant at the Columbia Presbyterian Medical Center during the1980s, which facilitated the author’s exploration of the clinical and experimental use of this material.


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Copyright information

© Société Internationale de Chirurgie 2009

Authors and Affiliations

  1. 1.Department of Surgery, Surgical Therapeutic Advancement CenterUniversity of Virginia Health SystemCharlottesvilleUSA

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