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Minimally Invasive Surgical Treatment of Hepatocellular Carcinoma: Long-Term Outcome

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Abstract

Background

Laparoscopic liver resection for hepatocellular carcinoma (HCC) is still a matter of debate because of the uncertainty of the long-term results and the fear of compromising the oncological resection. Published findings on survival and outcome after laparoscopic liver resection for HCC are scarce still. The aim of the present study was to report the perioperative and long-term outcome of minimally invasive surgical treatment of HCC.

Methods

From January 1998 to November 2008, all patients with HCC who underwent laparoscopic liver resection in our unit were included. A prospectively collected database was analyzed retrospectively. Perioperative outcome included procedure-related morbidity and mortality. Long-term outcome included 5-year overall survival and disease-free survival.

Results

During the study period, 30 consecutive patients with HCC underwent laparoscopic liver resection (hand-assisted laparoscopic liver resection, n = 22; total laparoscopic liver resection, n = 7; converted to open approach, n = 1). The mean tumor size was 2.8 cm. The mean operating time was 139.4 min, and 90% of patients had R0 resection and 10% of patients had R1 resection. The hospital mortality and morbidity rates were 0 and 20%, respectively. The mean hospital stay was 7.4 days. For those patients (n = 22) with a minimal follow-up of 24 months, the 5-year overall and disease-free survival rates were 50 and 36%, respectively. No port site recurrence occurred.

Conclusions

This study showed that laparoscopic liver resection for HCC was feasible and safe in selected patients. The long-term survival was also favorable.

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References

  1. Leong TY, Leong AS (2008) Epidemiology. In: Lau WY (ed) Hepatocellular carcinoma. World Scientific Publishing Co. Pvt. Ltd, Singapore, pp 1–24

    Google Scholar 

  2. El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557–25576

    Article  PubMed  CAS  Google Scholar 

  3. Lau WY (2000) Primary hepatocellular carcinoma. In: Blumgart LH, Fong Y (eds) Surgery of the liver and biliary tract, vol II, 2nd edn. WB Saunders Company, London, pp 1423–1450

    Google Scholar 

  4. Lau WY (2002) Management of hepatocellular carcinoma. J R Coll Surg Edinb 47:389–399

    PubMed  CAS  Google Scholar 

  5. Lai EC, Lau WY (2005) The continuing challenge of hepatic cancer in Asia. Surgeon 3:210–215

    Article  PubMed  CAS  Google Scholar 

  6. Lau WY, Lai EC (2008) Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int 7:237–257

    PubMed  Google Scholar 

  7. Lau WY, Lai EC (2009) The current role of radiofrequency ablation in the management of hepatocellular carcinoma: a systematic review. Ann Surg 249:20–25

    Article  PubMed  Google Scholar 

  8. Liu R (2008) Laparoscopic liver resection. In: Lau WY (ed) Hepatocellular carcinoma. World Scientific Publishing Co. Pvt. Ltd, Singapore, pp 491–506

    Google Scholar 

  9. Tang CN, Li MK (2002) Laparoscopic-assisted liver resection. J Hepatobiliary Pancreat Surg 9:105–110

    Article  PubMed  Google Scholar 

  10. Tang CN, Tsui KK, Ha JP et al (2006) A single-centre experience of 40 laparoscopic liver resections. Hong Kong Med J 12:419–425

    PubMed  CAS  Google Scholar 

  11. Lai EC, Tang CN, Ha JP et al (2009) Laparoscopic liver resection for hepatocellular carcinoma: 10-year experience in a single center. Arch Surg 144:143–147

    Article  PubMed  Google Scholar 

  12. Gagner M, Rogula T, Selzer D (2004) Laparoscopic liver resection: benefits and controversies. Surg Clin North Am 84:451–462

    Article  PubMed  Google Scholar 

  13. Gigot JF, Glineur D, Santiago Azagra J, Hepatobiliary, Pancreatic Section of the Royal Belgian Society of Surgery, the Belgian Group for Endoscopic Surgery et al (2002) Laparoscopic liver resection for malignant liver tumors: preliminary results of a multicenter European study. Ann Surg 236:90–97

    Article  PubMed  Google Scholar 

  14. Cherqui D, Laurent A, Tayar C et al (2006) Laparoscopic liver resection for peripheral hepatocellular carcinoma in patients with chronic liver disease: midterm results and perspectives. Ann Surg 243:499–506

    Article  PubMed  Google Scholar 

  15. Dagher I, Lainas P, Carloni A et al (2008) Laparoscopic liver resection for hepatocellular carcinoma. Surg Endosc 22:372–378

    Article  PubMed  Google Scholar 

  16. Vibert E, Perniceni T, Levard H et al (2006) Laparoscopic liver resection. Br J Surg 93:67–72

    Article  PubMed  CAS  Google Scholar 

  17. Shimada M, Hashizume M, Maehara S et al (2001) Laparoscopic hepatectomy for hepatocellular carcinoma. Surg Endosc 15:541–544

    Article  PubMed  CAS  Google Scholar 

  18. Laurent A, Cherqui D, Lesurtel M et al (2003) Laparoscopic liver resection for subcapsular hepatocellular carcinoma complicating chronic liver disease. Arch Surg 138:763–769

    Article  PubMed  Google Scholar 

  19. Belli G, Fantini C, D’Agostino A et al (2005) Laparoscopic hepatic resection for completely exophytic hepatocellular carcinoma on cirrhosis. J Hepatobiliary Pancreat Surg 12:488–493

    Article  PubMed  Google Scholar 

  20. Kaneko H, Takagi S, Otsuka Y et al (2005) Laparoscopic liver resection of hepatocellular carcinoma. Am J Surg 189:190–194

    Article  PubMed  Google Scholar 

  21. Chen HY, Juan CC, Ker CG (2008) Laparoscopic liver surgery for patients with hepatocellular carcinoma. Ann Surg Oncol 15:800–806

    Article  PubMed  Google Scholar 

  22. Huang MT, Lee WJ, Wang W et al (2003) Hand-assisted laparoscopic hepatectomy for solid tumor in the posterior portion of the right lobe: initial experience. Ann Surg 238:674–679

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong SAR, China

    Eric C. H. Lai, Chung Ngai Tang, George P. C. Yang & Michael K. W. Li

Authors
  1. Eric C. H. Lai
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  2. Chung Ngai Tang
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  3. George P. C. Yang
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  4. Michael K. W. Li
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Corresponding author

Correspondence to Eric C. H. Lai.

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Lai, E.C.H., Tang, C.N., Yang, G.P.C. et al. Minimally Invasive Surgical Treatment of Hepatocellular Carcinoma: Long-Term Outcome. World J Surg 33, 2150–2154 (2009). https://doi.org/10.1007/s00268-009-0155-7

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  • DOI: https://doi.org/10.1007/s00268-009-0155-7

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