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The Role of the Platelet-Rich Plasma in Accelerating the Wound-Healing Process and Recovery in Patients Being Operated for Pilonidal Sinus Disease: Preliminary Results

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Abstract

Background

Because of the poor quality of life that results from the open technique (open excision and packing) for surgically treating pilonidal cyst disease, several alternatives that accelerate the wound-healing process have been proposed. This study aimed to evaluate the effect of platelet-derived growth factors on the healing process.

Methods

Fifty-two patients with pilonidal sinus disease who underwent open excision and secondary closure of the surgical wound (n = 22) or additional local postoperative infusion of platelet-derived growth factors (n = 30) were evaluated. Duration of total wound healing and time to return to normal activities were evaluated. Quality of life of patients in each group was assessed via a stabilized questionnaire.

Results

Wound-healing rates were much greater for the platelet group (p < 0.01). Complete healing of the surgical wound required 24 days for the platelet group while the respective time for the control group was more than 30 days (p < 0.01). Patients in the platelet group returned to their normal activities around the postoperative day 17 when mean wound volume was about 10 cc, while control group patients managed to do so around the postoperative day 25.

Conclusions

These data provide evidence that the use of platelet-derived growth factors directly to the surgical wound enhances the healing process resulting in faster recovery of patients surgically treated for pilonidal sinus disease.

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Authors and Affiliations

  1. General Surgery Department, University Hospital of Larissa, Larissa, 41110, Greece

    Michail Spyridakis, Gregory Christodoulidis, Constantine Chatzitheofilou, Dimitris Symeonidis & Konstantinos Tepetes

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  1. Michail Spyridakis
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  2. Gregory Christodoulidis
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  3. Constantine Chatzitheofilou
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  4. Dimitris Symeonidis
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  5. Konstantinos Tepetes
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Correspondence to Michail Spyridakis.

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Spyridakis, M., Christodoulidis, G., Chatzitheofilou, C. et al. The Role of the Platelet-Rich Plasma in Accelerating the Wound-Healing Process and Recovery in Patients Being Operated for Pilonidal Sinus Disease: Preliminary Results. World J Surg 33, 1764–1769 (2009). https://doi.org/10.1007/s00268-009-0046-y

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  • DOI: https://doi.org/10.1007/s00268-009-0046-y

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