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High Postoperative Interleukin-8 Levels Related to Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery

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Abstract

Background

Atrial fibrillation (AF) is the most frequently encountered postoperative arrhythmic complication after coronary artery bypass graft (CABG). There is increasing evidence to support the influence of inflammation in the pathogenesis of AF. The aim of the present study was to investigate the relation of postoperative new AF and systemic inflammatory changes after CABG.

Methods

A total of 113 CABG patients were recruited in the present study. Holter data from 24-hour electrocardiography were collected from 1 day before the operation to postoperative day 2 (POD2). AF was registered as positive if any AF event occurred. Serum cytokine, including interleukin (IL)-6, IL-8, and IL-10 were analyzed before and after surgery.

Results

The overall incidences of postoperative AF and sustained AF were 36.3% and 31.9%, respectively. Patients with postoperative AF had longer respiratory treatment, intensive care unit treatment, and inotropic medication periods. Similar concentrations of serum IL-6 were found after surgery in patients with and without AF. The concentrations of serum IL-8 was significantly higher at 2 hours and on POD1 and POD2 in patients with postoperative AF. The concentration of serum IL-10 was significantly higher on POD1 in patients with postoperative AF.

Conclusions

Postoperative AF in CABG patients is associated with a more complicated postoperative outcome. Higher concentrations of serum IL-8 in CABG patients with postoperative AF suggested that an influence of inflammation in the pathogenesis postoperative AF after open heart surgery.

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Acknowledgments

The study was supported by the National Science Fund for Distinguished Young Scholars of China (30525020), Guangdong Science and Technology Department Key Guiding Projects (2004B30601012), and the Research Foundation of Tampere University Hospital, Finland.

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Authors and Affiliations

  1. Department of Cardiac Surgery, Heart Center, Affiliated 1st Hospital, Sun Yat-sen University, Guang Zhou, 510080, China

    Zhong-Kai Wu

  2. Department of Cardiac Surgery, Heart Center, Tampere University Hospital, Tampere, Finland

    Zhong-Kai Wu, Jari Laurikka & Matti R. Tarkka

  3. Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland

    Saila Vikman

  4. Immunopharmacology Research Group, Medical School, University of Tampere and Research Unit, Tampere University Hospital, Tampere, Finland

    Riina Nieminen & Eeva Moilanen

Authors
  1. Zhong-Kai Wu
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  2. Jari Laurikka
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  3. Saila Vikman
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  4. Riina Nieminen
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  6. Matti R. Tarkka
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Correspondence to Zhong-Kai Wu.

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Wu, ZK., Laurikka, J., Vikman, S. et al. High Postoperative Interleukin-8 Levels Related to Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery. World J Surg 32, 2643–2649 (2008). https://doi.org/10.1007/s00268-008-9758-7

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  • DOI: https://doi.org/10.1007/s00268-008-9758-7

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