Skip to main content

Delay from Symptom Onset Increases the Conversion Rate in Laparoscopic Cholecystectomy for Acute Cholecystitis

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

An Erratum to this article was published on 04 October 2008

Abstract

Background

Randomized trials suggest that laparoscopic cholecystectomy should be performed on first admission for acute cholecystitis. However, this is not widely practiced, possibly because of a perceived high conversion rate. We hypothesized that delay from onset of symptoms may increase the conversion rate.

Methods

We performed a retrospective case note review of patients undergoing emergency cholecystectomy in a single institution between January 2002 and December 2005. We analyzed whether delay from onset of symptoms was related to the conversion rate in patients with a histopathological diagnosis of acute cholecystitis.

Results

Of patients who underwent emergency laparoscopic cholecystectomy in our institution, 32.4% (197/608) had acute cholecystitis on histopathology. The conversion rate of those with acute cholecystitis was considerably higher (24.4%) than for those with other pathologies (6.3%). For patients with acute cholecystitis, the conversion rates increased with duration of symptoms: 9.5%, 16.1%, 38.9%, and 38.6% for delays of 0–2 days, 3–4 days, 5–6 days, and > 6 days from symptom onset, respectively (chi-square for trend = 14.27, DF = 1, p = 0.00016). Most conversions were due to the presence of acute inflammatory adhesions.

Conclusions

Early intervention for acute cholecystitis (preferably within 2 days of onset of symptoms) is most likely to result in successful laparoscopic cholecystectomy; increasing delay is associated with conversion to open surgery.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. Lee HK, Han HS, Min SK, et al. (2005) Sex-based analysis of the outcome of laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 92:463–466

    Article  PubMed  CAS  Google Scholar 

  2. Lo CM, Liu CL, Fan ST, et al. (1998) Prospective randomized study of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Ann Surg 227:461–467

    Article  PubMed  CAS  Google Scholar 

  3. Lo CM, Liu CL, Lai EC, et al. (1996) Early versus delayed laparoscopic cholecystectomy for treatment of acute cholecystitis. Ann Surg 223:37–42

    Article  PubMed  CAS  Google Scholar 

  4. van der Linden W, Sunzel H (1970) Early versus delayed operation for acute cholecystitis. A controlled clinical trial. Am J Surg 120:7–13

    Article  PubMed  Google Scholar 

  5. Wilson RG, Macintyre IM, Nixon SJ, et al. (1992) Laparoscopic cholecystectomy as a safe and effective treatment for severe acute cholecystitis. BMJ 305:394–396

    Article  PubMed  CAS  Google Scholar 

  6. Lai PB, Kwong KH, Leung KL, et al. (1998) Randomized trial of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 85:764–767

    Article  PubMed  CAS  Google Scholar 

  7. Papi C, Catarci M, D’Ambrosio L, et al. (2004) Timing of cholecystectomy for acute calculous cholecystitis: a meta-analysis. Am J Gastroenterol 99:147–155

    Article  PubMed  Google Scholar 

  8. Shikata S, Noguchi Y, Fukui T (2005) Early versus delayed cholecystectomy for acute cholecystitis: a meta-analysis of randomized controlled trials. Surg Today 35:553–560

    Article  PubMed  Google Scholar 

  9. Cheruvu CV, Eyre-Brook IA (2002) Consequences of prolonged wait before gallbladder surgery. Ann R Coll Surg Engl 84:20–22

    PubMed  CAS  Google Scholar 

  10. Cameron IC, Chadwick C, Phillips J, et al. (2002) Acute cholecystitis—room for improvement? Ann R Coll Surg Engl 84:10–13

    PubMed  CAS  Google Scholar 

  11. Cameron IC, Chadwick C, Phillips J, et al. (2004) Management of acute cholecystitis in UK hospitals: time for a change. Postgrad Med J 80:292–294

    Article  PubMed  CAS  Google Scholar 

  12. Peng WK, Sheikh Z, Nixon SJ, et al. (2005) Role of laparoscopic cholecystectomy in the early management of acute gallbladder disease. Br J Surg 92:586–591

    Article  PubMed  CAS  Google Scholar 

  13. Kolla SB, Aggarwal S, Kumar A, et al. (2004) Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a prospective randomized trial. Surg Endosc 18:1323–1327

    Article  PubMed  CAS  Google Scholar 

  14. Liguori G, Bortul M, Castiglia D (2003) The treatment of laparoscopic cholecystectomy for acute cholecystitis. Ann Ital Chir 74:517–521

    PubMed  CAS  Google Scholar 

  15. Bhattacharya D, Senapati PS, Hurle R, et al. (2002) Urgent versus interval laparoscopic cholecystectomy for acute cholecystitis: a comparative study. J Hepatobiliary Pancreat Surg 9:538–542

    Article  PubMed  Google Scholar 

  16. Madan AK, Aliabadi-Wahle S, Tesi D, et al. (2002) How early is early laparoscopic treatment of acute cholecystitis? Am J Surg 183:232–236

    Article  PubMed  Google Scholar 

  17. Uchiyama K, Onishi H, Tani M, et al. (2004) Timing of laparoscopic cholecystectomy for acute cholecystitis with cholecystolithiasis. Hepatogastroenterology 51:346–348

    PubMed  Google Scholar 

  18. Kitano S, Matsumoto T, Aramaki M, et al. (2002) Laparoscopic cholecystectomy for acute cholecystitis. J Hepatobiliary Pancreat Surg 9:534–537

    Article  PubMed  Google Scholar 

  19. Cheema S, Brannigan AE, Johnson S, et al. (2003) Timing of laparoscopic cholecystectomy in acute cholecystitis. Ir J Med Sci 172:128–131

    Article  PubMed  CAS  Google Scholar 

  20. Knight JS, Mercer SJ, Somers SS, et al. (2004) Timing of urgent laparoscopic cholecystectomy does not influence conversion rate. Br J Surg 91:601–604

    Article  PubMed  CAS  Google Scholar 

  21. Karayiannakis AJ, Makri GG, Mantzioka A, et al. (1996) Postoperative pulmonary function after laparoscopic and open cholecystectomy. Br J Anaesth 77:448–452

    PubMed  CAS  Google Scholar 

  22. Lee KT, Shan YS, Wang ST, et al. (2005) Verress needle decompression of distended gallbladder to facilitate laparoscopic cholecystectomy in acute cholecystitis: a prospective study. Hepatogastroenterology 52:1388–1392

    PubMed  Google Scholar 

Download references

Acknowledgments

The authors are grateful to the Medical Records Department, Ninewells Hospital and Medical School, for support in retrieving case notes.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sirwan M. Hadad.

Additional information

The abstract was presented at the British Journal of Surgery Prize Session of the 7th World Congress of the International Hepato-Pancreato-Biliary Association, 10th Annual Meeting of the Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland in Edinburgh, UK, September 2006.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00268-008-9750-2

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hadad, S.M., Vaidya, J.S., Baker, L. et al. Delay from Symptom Onset Increases the Conversion Rate in Laparoscopic Cholecystectomy for Acute Cholecystitis. World J Surg 31, 1300–1303 (2007). https://doi.org/10.1007/s00268-007-9050-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-007-9050-2

Keywords

  • Conversion Rate
  • Laparoscopic Cholecystectomy
  • Acute Cholecystitis
  • Obstructive Jaundice
  • Bile Duct Injury