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Pancreatoduodenectomy for Distal Cholangiocarcinoma: Prognostic Impact of Lymph Node Metastasis

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Abstract

Background

The aim of this study was to identify useful prognostic factors in patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma.

Methods

The records of 36 patients with distal cholangiocarcinoma undergoing pancreatoduodenectomy were retrospectively reviewed. Potential clinicopathological prognostic factors that may affect survival were examined by univariate and multivariate analysis.

Results

There was no mortality. Overall survival rates were 75%, 54%, and 50% for 1, 3 and 5 years, respectively (median survival time, 26 months). Univariate analysis found that age (≧ 65 years), pancreatic invasion, duodenal invasion, lymph node metastasis, perineural invasion and a positive surgical margin were significant predictors of poor prognosis (P < 0.05). Furthermore, lymph node metastasis was found to be a significant independent predictor of poor prognosis by multivariate analysis (P = 0.043). Moreover, there were significant differences in the 5-year survival between patients with 2 or less involved lymph nodes and those with 3 or more positive nodes (P < 0.001). There were no 2-year survivors of the group of patients with 3 or more positive nodes.

Conclusions

These results suggest that the presence and number of lymph nodes exhibiting metastatic disease might be useful in predicting the postsurgical outcome in patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma.

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Authors and Affiliations

  1. Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Yoshiaki Murakami MD, Kenichiro Uemura MD, Yasuo Hayashidani MD, Takeshi Sudo MD, Hiroki Ohge MD & Taijiro Sueda MD

Authors
  1. Yoshiaki Murakami MD
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  2. Kenichiro Uemura MD
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  3. Yasuo Hayashidani MD
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  4. Takeshi Sudo MD
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  5. Hiroki Ohge MD
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  6. Taijiro Sueda MD
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Corresponding author

Correspondence to Yoshiaki Murakami MD.

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Murakami, Y., Uemura, K., Hayashidani, Y. et al. Pancreatoduodenectomy for Distal Cholangiocarcinoma: Prognostic Impact of Lymph Node Metastasis. World J. Surg. 31, 337–342 (2007). https://doi.org/10.1007/s00268-006-0224-0

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  • DOI: https://doi.org/10.1007/s00268-006-0224-0

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