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Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe

World Journal of Surgery volume 30, pages 1821–1828 (2006)Cite this article

Abstract

Background

Previous studies have shown that lymph node metastasis can be of prognostic value. In this study, we investigated the clinical significance of node metastasis focusing on metastasis in the central compartment for patients with papillary carcinoma located in one lobe.

Patients and Methods

We investigated the frequency of lymph node metastasis in 759 patients with papillary carcinoma to determine whether and how such metastasis affects disease-free survival (DFS).

Results

Central node metastasis was observed in 63% of patients, and the frequency was increased in relation to tumor size. The frequency of lateral node metastasis was 62.0%, which was also directly related to tumor size. On multivariate analysis of cases showing tumor larger than 1 cm, central node metastasis was recognized as an independent prognostic factor of DFS. The frequency of metastasis to the paratracheal nodes contralateral to the tumor was drastically elevated for tumors larger than 1 cm, but metastasis to this region did not independently predict worse DFS.

Conclusion

Central node metastasis independently predicts a worse DFS for patients with papillary carcinoma larger than 1 cm.

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Affiliations

  1. Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011 , Japan

    Yasuhiro Ito MD, UVT, Tomoo Jikuzono MD, Takuya Higashiyama MD, Shuji Asahi MD, Chisato Tomoda MD, Yuuki Takamura MD, Akihiro Miya MD, Kaoru Kobayashi MD, Fumio Matsuzuka MD, Kanji Kuma MD & Akira Miyauchi MD

  2. Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011 , Japan

    Yasuhiro Ito MD, UVT

Authors
  1. Yasuhiro Ito MD, UVT
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  2. Tomoo Jikuzono MD
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  3. Takuya Higashiyama MD
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  4. Shuji Asahi MD
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  5. Chisato Tomoda MD
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  6. Yuuki Takamura MD
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  7. Akihiro Miya MD
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  8. Kaoru Kobayashi MD
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  9. Fumio Matsuzuka MD
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  10. Kanji Kuma MD
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  11. Akira Miyauchi MD
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Corresponding author

Correspondence to Yasuhiro Ito MD, UVT.

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Ito, Y., Jikuzono, T., Higashiyama, T. et al. Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe. World J. Surg. 30, 1821–1828 (2006). https://doi.org/10.1007/s00268-006-0211-5

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  • DOI: https://doi.org/10.1007/s00268-006-0211-5

Keywords

  • Node Metastasis
  • Papillary Carcinoma
  • Central Compartment
  • Lateral Node
  • Lateral Node Metastasis