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Clinical Significance of Occult Metastatic Melanoma in Sentinel Lymph Nodes and Other High-risk Factors Based on Long-term Follow-up

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Abstract

Selective sentinel lymphadenectomy (SSL) following preoperative lymphoscintigraphy is the most significant recent advance in the management of patients with primary melanoma. This study evaluates the prognostic value of sentinel lymph node (SLN) status and other risk factors in predicting survival and recurrence in patients with primary cutaneous melanoma. From October 1993 to July 1998 a series of 412 patients with primary invasive melanoma underwent SSL at the UCSF/ Mt. Zion Melanoma Center. The outcome of 363 evaluable patients is summarized in this study. The factors related to survival and disease recurrence were analyzed by Cox proportional hazard regression models. The overall incidence of patients with positive SLNs was 18%. Over a median follow-up of 4.8 years, the overall mortality rate in patients with primary cutaneous melanoma was 18.7%, and 74 recurrences occurred (20.4%). Mortality was significantly related to SLN status [HR = 2.06; 95% Confidence interval (CI) 1.18, 3.58], angiolymphatic invasion (HR = 2.21; 95% CI 1.08, 4.55), ulceration (HR = 1.79; 95% CI 1.02, 3.15), mitotic index (HR =1.38; 95% CI 1.01, 1.90), and tumor thickness (HR = 2.20, 95% CI 1.21, 3.99). Factors significantly related to disease-free survival included SLN status (HR = 2.09; 95% CI 1.31, 3.34), tumor thickness (HR = 1.89; 95%. CI 1.20,2.98), and age (HR= 1.26 95% CI 1.08, 1.47). SLN status was the most significant factor for melanoma recurrence and death. Other important predictors include tumor thickness, ulceration, lymphatic invasion, and mitotic index.

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Acknowledgments

This study was supported in part by the Eva B. Buck Charitable Trust and the UCSF/Mount Zion Auxiliary Fund.

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Authors and Affiliations

  1. Department of Surgery, University of California, San Francisco, Medical Center at Mount Zion and CSF Comprehensive Cancer Center, 1600 Divisadero Street, Box 1674, San Francisco, California 94143, USA

    Stanley P.L. Leong M.D., Robert P. Kim M.D., Dennis H. Nguyen B.A., Kensho Iwanaga B.A. & Robert E. Allen Jr. M.D.

  2. Department of Dermatology, University of California, San Francisco, Medical Center at Mount Zion and CSF Comprehensive Cancer Center, 1600 Divisadero Street, San Francisco, California 94143, USA

    Mohammed Kashani-Sabet M.D. & Richard W. Sagebiel M.D.

  3. Medical Statistics Section, University of Alabama at Birmingham Comprehensive Cancer Center, 1802 6th Avenue South, NP 2540, Birmingham, Alabama 35294, USA

    Renee A. Desmond Ph.D., Yuting Zhang M.S. & Seng-Jaw Soong Ph.D.

  4. Department of Pathology, University of California, San Francisco, Medical Center at Mount Zion and CSF Comprehensive Cancer Center, 1600 Divisadero Street, San Francisco, California 94143, USA

    Patrick A. Treseler M.D., Ph.D.

  5. Department of Nuclear Medicine, University of California, San Francisco, Medical Center at Mount Zion and CSF Comprehensive Cancer Center, 1600 Divisadero Street, San Francisco, California 94143, USA

    Eugene T. Morita M.D.

Authors
  1. Stanley P.L. Leong M.D.
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  2. Mohammed Kashani-Sabet M.D.
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  5. Dennis H. Nguyen B.A.
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  6. Kensho Iwanaga B.A.
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  7. Patrick A. Treseler M.D., Ph.D.
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  8. Robert E. Allen Jr. M.D.
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  9. Eugene T. Morita M.D.
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  10. Yuting Zhang M.S.
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  11. Richard W. Sagebiel M.D.
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  12. Seng-Jaw Soong Ph.D.
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Correspondence to Stanley P.L. Leong M.D..

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Leong, S.P., Kashani-Sabet, M., Desmond, R.A. et al. Clinical Significance of Occult Metastatic Melanoma in Sentinel Lymph Nodes and Other High-risk Factors Based on Long-term Follow-up. World J. Surg. 29, 683–691 (2005). https://doi.org/10.1007/s00268-005-7736-x

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