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World Journal of Surgery

, Volume 29, Issue 9, pp 1131–1134 | Cite as

When Is Curative Gastrectomy Justified for Gastric Cancer with Positive Peritoneal Lavage Cytology but Negative Macroscopic Peritoneal Implant?

  • Isao MiyashiroEmail author
  • Ko Takachi
  • Yuichiro Doki
  • Osamu Ishikawa
  • Hiroaki Ohigashi
  • Kohei Murata
  • Yo Sasaki
  • Shingi Imaoka
  • Akihiko Nakaizumi
  • Akemi Takenaka
  • Hiroshi Furukawa
  • Masahiro Hiratsuka
Article

Abstract

For gastric cancer patients who have no peritoneal seeding at a macroscopic level but positive results in the peritoneal lavage cytology (PLC), the prognostic benefit expected by surgical resection is still controversial. During the period 1975–1994 as series of 417 consecutive patients without distant organ metastases underwent surgical resection for gastric cancer that had invaded the subserosal or deeper layers of the stomach wall. Immediately after laparotomy, the pouch of Douglas was washed with 100 ml of physiologic saline solution, and the fluid was collected for cytologic examination (four slide glasses) using Giemsa and Papanicolaou staining methods. According to the macroscopic (P) and cytologic (Cyt) results, the 417 patients were classified into three groups: P+ (n = 97); P/Cyt+ (n = 25); and P/Cyt (n = 295). Their 3-year survival rates after surgical resection were 4%, 24%, and 48%, respectively (p = 0.0001: P/Cyt+ vs. P/Cyt; p = 0.0018: P/Cyt+ vs. P+. Among the 25 P/Cyt+ patients, postoperative survival was not associated with the T stage, N stage, cellular atypism, or cluster formation but with the number of cancer cells per slide during PLC. The 3-year survival rate was 35% for the subgroup with fewer than 10 cancer cells per slide (17 patients) and 0% for the other subgroup with 10 or more cancer cells per slide (8 patients) (p = 0.017). For P/Cyt+ patients, who represent a subgroup of gastric cancer patients with an intermediate survival rate between the P/Cyt and P+ patients, the number of cancer cells observed during PLC offers a potent prognostic indicator for the gastrectomy.

Keywords

Gastric Cancer Gastric Cancer Patient Cluster Formation Peritoneal Dissemination Laparoscopic Staging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirurgie 2005

Authors and Affiliations

  • Isao Miyashiro
    • 1
    Email author
  • Ko Takachi
    • 1
  • Yuichiro Doki
    • 1
  • Osamu Ishikawa
    • 1
  • Hiroaki Ohigashi
    • 1
  • Kohei Murata
    • 1
  • Yo Sasaki
    • 1
  • Shingi Imaoka
    • 1
  • Akihiko Nakaizumi
    • 2
  • Akemi Takenaka
    • 2
  • Hiroshi Furukawa
    • 3
  • Masahiro Hiratsuka
    • 4
  1. 1.Department of SurgeryOsaka Medical Center for Cancer and Cardiovascular DiseasesHigashinari-kuJapan
  2. 2.Department of CytologyOsaka Medical Center for Cancer and Cardiovascular DiseasesHigashinari-kuJapan
  3. 3.Department of SurgerySakai Municipal HospitalSakaiJapan
  4. 4.Department of SurgeryItami Municipal HospitalItamiJapan

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