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Prospectively Randomized Trial Using Perioperative Low-dose Octreotide to Prevent Organ-related and General Complications after Pancreatic Surgery and Pancreatico-jejunostomy

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An Erratum to this article was published on 10 March 2006

Abstract

The aim of the present study was to evaluate the influence of low-dose perioperative octreotide on the prevention of complications (pancreatic fistula and general complications) in patients undergoing pancreatic surgery followed by pancreaticojejunostomy. A total of 105 patients were randomized to receive either octreotide 0.1 mg subcutaneously 3 times/day for a total of 7 days or no octreotide. The primary endpoints were the occurence of a pancreatic fistula and or general complications, including extended length of hospital stay. There were 25 surgical draining procedures performed and 80 duodenopancreatectomies with or without preservation of the pylorus. In all, 25 (23.8%) of the patients were treated for chronic pancreatitis, 8 (7.6%) for benign tumoral disease, and 72 (68.6%) for carcinoma. All patients underwent pancreaticojejunostomy.

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Acknowledgments

The authors thank MRS. Inge Baeke for secretarial assistance.

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Authors and Affiliations

  1. Department of Surgery, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Uwe J. Hesse M.D., Ph.D., Christophe De Decker M.D., Philippe Houtmeyers M.D., Wim Ceelen M.D., Piet Pattyn M.D., Ph.D., Roberto Troisi M.D., Ph.D. & Bernard de Hemptinne M.D.

  2. Department of Pathology, Ghent University Hospital, De Printelaan 185, 9000, Ghent, Belgium

    Pieter Demetter M.D., Ph.D.

Authors
  1. Uwe J. Hesse M.D., Ph.D.
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  2. Christophe De Decker M.D.
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  3. Philippe Houtmeyers M.D.
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  4. Pieter Demetter M.D., Ph.D.
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  5. Wim Ceelen M.D.
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  6. Piet Pattyn M.D., Ph.D.
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  7. Roberto Troisi M.D., Ph.D.
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  8. Bernard de Hemptinne M.D.
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Corresponding author

Correspondence to Uwe J. Hesse M.D., Ph.D..

Additional information

Present address: Klinikum Stuttgart–Krankenhaus Bad Cannstatt Priessnitzweg 24, D-70374 Stuttgart.

An erratum to this article is available at http://dx.doi.org/10.1007/s00268-005-7996-5.

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Hesse, U.J., De Decker, C., Houtmeyers, P. et al. Prospectively Randomized Trial Using Perioperative Low-dose Octreotide to Prevent Organ-related and General Complications after Pancreatic Surgery and Pancreatico-jejunostomy. World J. Surg. 29, 1325–1328 (2005). https://doi.org/10.1007/s00268-005-7546-1

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