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7201 Carcinoids: Increasing Incidence Overall and Disproportionate Mortality in the Elderly

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Abstract

Introduction

The aim of the study was to determine outcomes for respiratory and gastrointestinal carcinoid tumors utilizing a large cancer registry.

Methods

Cases of respiratory and gastrointestinal carcinoid from the Florida Cancer Data System (FCDS) from 1981 to 2001 were reviewed. Descriptive statistics, age-adjusted tumor incidence, and survival rates were determined.

Results

A total of 7201 cases of malignant carcinoid were identified. Pulmonary and gastrointestinal carcinoid tumors comprised 82% of all carcinoids encountered. The mean age was 64.4 ± 0.15 years. Stratified by location, there were 3000 (51.4%) foregut carcinoids (including those found in the respiratory tree—2325 in the lung), 2130 (36.5%) midgut carcinoids, and 712 (12.2%) hindgut carcinoids. Second, distinct malignancies were observed in 23% of cases. The total age-adjusted incidence rate has increased from 0.62 per 100,000 in 1980 to 5.17 per 100,000 in 2000. Overall median survival was 21.97 months. The median survival was 19.0 months for foregut carcinoids (excluding those arising in the respiratory tract); 33.9 months for midgut tumors; and 22.7 months for hindgut carcinoids. There was a statistically significant better survival for those with midgut tumors than for those in the other groups (P < 0.001). Age < 60 years, white race, and female sex were all associated with better survival (P < 0.01).

Conclusions

The incidence of pulmonary and gastrointestinal carcinoids has dramatically increased since 1981. Tumor location and age ≥ 60 years are the strongest predictors of mortality.

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Authors and Affiliations

  1. The Dewitt Daughtry Family Department of Surgery, University of Miami School of Medicine, Coral Gables, FL, 33124, USA

    Eduardo A. Perez MD, Leonidas G. Koniaris MD, Sarah E. Snell MD, Juan C. Gutierrez MD, William E. Sumner III MD, David J. Lee PhD, Nicole C. Hodgson MD, Alan S. Livingstone MD & Dido Franceschi MD

  2. 3550 Sylvester Comprehensive Cancer Center (310T), 1475 NW 12th Avenue, Miami, FL, 33136, USA

    Leonidas G. Koniaris MD

Authors
  1. Eduardo A. Perez MD
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  2. Leonidas G. Koniaris MD
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  3. Sarah E. Snell MD
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  4. Juan C. Gutierrez MD
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  5. William E. Sumner III MD
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  6. David J. Lee PhD
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  7. Nicole C. Hodgson MD
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  8. Alan S. Livingstone MD
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  9. Dido Franceschi MD
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Corresponding author

Correspondence to Leonidas G. Koniaris MD.

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Perez, E.A., Koniaris, L.G., Snell, S.E. et al. 7201 Carcinoids: Increasing Incidence Overall and Disproportionate Mortality in the Elderly. World J Surg 31, 1022–1030 (2007). https://doi.org/10.1007/s00268-005-0774-6

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  • DOI: https://doi.org/10.1007/s00268-005-0774-6

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