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Benign Peritoneal Cystic Mesothelioma

Abstract

Background

Benign peritoneal cystic mesothelioma (BPCM) is a rare tumor of unknown origin, most frequently encountered in women of reproductive age. Etiology is unknown; definitions and terminology are confusing, and preoperative diagnosis is difficult. Several differential diagnoses must be considered.

Methods

Based on our own clinical experience and a review of the relevant literature, we address clinical challenges and controversies of importance.

Results

Current literature on BPCM is mostly based on small case reports. Complete surgical resection is recommended if possible. Nevertheless, recurrent disease is not uncommon. Clinical positive effects of various adjuvant medical treatments remain to be shown.

Conclusions

Lack of consistent definitions, various treatment approaches, and mostly short follow-up times make it difficult to draw any firm conclusions from published reports. The natural history of this rare disease is less than well clarified. When possible, in an individual patient, surgical resection with curative intent seems to be the treatment of choice.

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References

  1. 1.

    Sawh RN, Malpica A, Deavers MT, et al. Benign cystic mesothelioma of the peritoneum: a clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status. Hum Pathol 2003;34:369–374

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Daya D, McCaughey WT. Pathology of the peritoneum: a review of selected topics. Semin Diagn Pathol 1991;8:277–289

    PubMed  CAS  Google Scholar 

  3. 3.

    Ross MJ, Welch WR, Scully RE. Multilocular peritoneal inclusion cysts (so-called cystic mesotheliomas). Cancer 1989;64:1336–1346

    PubMed  CAS  Google Scholar 

  4. 4.

    Rosai J. Surgical Pathology, 9th edition, Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Toronto, Mosby, 2004

  5. 5.

    Hejmadi R, Ganesan R, Kamal N. Malignant transformation of a well-differentiated peritoneal papillary mesothelioma. Acta Cytol 2003;47:517–518

    PubMed  Google Scholar 

  6. 6.

    Gonzalez-Moreno S, Yan H, Alcorn KW, et al. Malignant transformation of “benign” cystic mesothelioma of the peritoneum. J Surg Oncol 2002;79:243–251

    PubMed  Google Scholar 

  7. 7.

    Hutchinson R, Sokhi GS. Multicystic peritoneal mesothelioma: not a benign condition. Eur J Surg 1992;158:451–453

    PubMed  CAS  Google Scholar 

  8. 8.

    Iversen OH, Hovig T, Brandtzaeg P. Peritoneal, benign, cystic mesothelioma with free-floating cysts, re-examined by new methods. A case report. Acta Pathol Microbiol Immunol Scand 1988;96:123–127

    CAS  Google Scholar 

  9. 9.

    Moriwaki Y, Kobayashi S, Harada H, et al. Cystic mesothelioma of the peritoneum. J Gastroenterol 1996;31:868–874

    PubMed  CAS  Google Scholar 

  10. 10.

    O’Neil JD, Ros PR, Storm BL, et al. Cystic mesothelioma of the peritoneum. Radiology 1989;170:333–337

    PubMed  CAS  Google Scholar 

  11. 11.

    De Perrot M, Brundler M, Totsch M, et al. Mesenteric cysts. Toward less confusion? Dig Surg 2000;17:323–328

    PubMed  Google Scholar 

  12. 12.

    Kjellevold K, Nesland JM, Holm R, et al. Multicystic peritoneal mesothelioma. Pathol Res Pract 1986;181:767–773

    PubMed  CAS  Google Scholar 

  13. 13.

    Sethna K, Mohamed F, Marchettini P, et al. Peritoneal cystic mesothelioma: a case series. Tumori 2003;89:31–35

    PubMed  Google Scholar 

  14. 14.

    Van Ruth S, Bronkhorst MW, van Coevorden F, et al. Peritoneal benign cystic mesothelioma: a case report and review of the literature. Eur J Surg Oncol 2002;28:192–195

    PubMed  Google Scholar 

  15. 15.

    Katsube Y, Mukai K, Silverberg SG. Cystic mesothelioma of the peritoneum: a report of five cases, review of the literature. Cancer 1982;50:1615–1622

    PubMed  CAS  Google Scholar 

  16. 16.

    Hafner M, Novacek G, Herbst F, et al. Giant benign cystic mesothelioma: a case report and review of literature. Eur J Gastroenterol Hepatol 2002;14:77–80

    PubMed  CAS  Google Scholar 

  17. 17.

    Iwasaki J, Yu TJ, Tamaru J, et al. A cystic adenomatoid tumor of the uterus simulating lymphangioma grossly. Acta Pathol Jpn 1985;35:989–993

    PubMed  CAS  Google Scholar 

  18. 18.

    Quigley JC, Hart WR. Adenomatoid tumors of the uterus. Am J Clin Pathol 1981;76:627–635

    PubMed  CAS  Google Scholar 

  19. 19.

    Asensio JA, Goldblatt P, Thomford NR. Primary malignant peritoneal mesothelioma. A report of seven cases, a review of the literature. Arch Surg 1990;125:1477–1481

    PubMed  CAS  Google Scholar 

  20. 20.

    Jones DE, Silver D. Peritoneal mesotheliomas. Surgery 1979;86:556–560

    PubMed  CAS  Google Scholar 

  21. 21.

    Antman KH. Clinical presentation, natural history of benign and malignant mesothelioma. Semin Oncol 1981;8:313–320

    PubMed  CAS  Google Scholar 

  22. 22.

    Mennemeyer R, Smith M. Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer 1979;44:692–698

    PubMed  CAS  Google Scholar 

  23. 23.

    Ulvestad B, Kjaerheim K, Martinsen JI, et al. Cancer incidence among members of the Norwegian trade union of insulation workers. J Occup Environ Med 2004;46:84–89

    PubMed  Google Scholar 

  24. 24.

    De Toma G, Nicolanti V, Plocco M, et al. Cystic peritoneal mesothelioma: report of a case. Surg Today 2000;30:98–100

    PubMed  Google Scholar 

  25. 25.

    Datta RV, Paty PB. Cystic mesothelioma of the peritoneum. Eur J Surg Oncol 1997;23:461–462

    Article  PubMed  CAS  Google Scholar 

  26. 26.

    Carpenter HA, Lancaster JR, Lee RA. Multilocular cysts of the peritoneum. Mayo Clin Proc 1982;57:634–638

    PubMed  CAS  Google Scholar 

  27. 27.

    Burrig KF, Pfitzer P, Hort W. Well-differentiated papillary mesothelioma of the peritoneum: a borderline mesothelioma. Report of two cases, review of literature. Virchows Arch A Pathol Anat Histopathol 1990;417:443–447

    PubMed  CAS  Google Scholar 

  28. 28.

    Riddell RH, Goodman MJ, Moossa AR. Peritoneal malignant mesothelioma in a patient with recurrent peritonitis. Cancer 1981;48:134–139

    PubMed  CAS  Google Scholar 

  29. 29.

    Kumar D, Dhar A, Jain R, et al. Benign cystic peritoneal mesothelioma in a man. Indian J Gastroenterol 1998;17:156–157

    PubMed  CAS  Google Scholar 

  30. 30.

    Ozgen A, Akata D, Akhan O, et al. Giant benign cystic peritoneal mesothelioma: US, CT, and MRI findings. Abdom Imaging 1998;23:502–504

    PubMed  CAS  Google Scholar 

  31. 31.

    Moore JH Jr, Crum CP, Chandler JG, et al. Benign cystic mesothelioma. Cancer 1980;45:2395–2399

    PubMed  Google Scholar 

  32. 32.

    Hasan AK, Sinclair DJ. Case report: calcification in benign cystic peritoneal mesothelioma. Clin Radiol 1993;48:66–67

    PubMed  CAS  Google Scholar 

  33. 33.

    Takenouchi Y, Oda K, Takahara O, et al. Report of a case of benign cystic mesothelioma. Am J Gastroenterol 1995;90:1165–1167

    PubMed  CAS  Google Scholar 

  34. 34.

    Bhandarkar DS, Smith VJ, Evans DA, et al. Benign cystic peritoneal mesothelioma. J Clin Pathol 1993;46:867–868

    PubMed  CAS  Google Scholar 

  35. 35.

    Tao LC. Aspiration biopsy cytology of mesothelioma. Diagn Cytopathol 1989;5:14–21

    PubMed  CAS  Google Scholar 

  36. 36.

    Usha Kiran TS, Agboola A, Davies R, et al. Benign cystic mesothelioma: a diagnostic dilemma. Aust N Z J Obstet Gynaecol 2002;42:552–554

    PubMed  CAS  Google Scholar 

  37. 37.

    Raafat F, Egan M. Benign cystic mesothelioma of the peritoneum: immunohistochemical, ultrastructural features in a child. Pediatr Pathol 1988;8:321–329

    PubMed  CAS  Google Scholar 

  38. 38.

    Friedman MT, Gentile P, Tarectecan A, et al. Malignant mesothelioma: immunohistochemistry and DNA ploidy analysis as methods to differentiate mesothelioma from benign reactive mesothelial cell proliferation and adenocarcinoma in pleural and peritoneal effusions. Arch Pathol Lab Med 1996;120:959–966

    PubMed  CAS  Google Scholar 

  39. 39.

    Vara-Thorbeck C, Toscano-Mendez R. Peritoneal cystic mesothelioma. Surg Endosc 2002;16:220

    Article  PubMed  CAS  Google Scholar 

  40. 40.

    Rosai J, Dehner LP. Nodular mesothelial hyperplasia in hernia sacs: a benign reactive condition simulating a neoplastic process. Cancer 1975;35:165–175

    PubMed  CAS  Google Scholar 

  41. 41.

    Tzanakakis G, McCully KS, Vezeridis MP. Benign papillary mesothelioma of the peritoneum: a consideration in the differential diagnosis of peritoneal implants. South Med J 1989;82:1579–1580

    PubMed  CAS  Google Scholar 

  42. 42.

    Ricci F, Borzellino G, Ghimenton C, et al. Benign cystic mesothelioma in a male patient: surgical treatment by the laparoscopic route. Surg Laparosc Endosc 1995;5:157–160

    PubMed  CAS  Google Scholar 

  43. 43.

    Meister T, Birkfellner T, Poremba C, et al. Papillary mesothelioma of the peritoneum in the absence of asbestos exposure. Z Gastroenterol 2003;41:329–332

    Article  PubMed  CAS  Google Scholar 

  44. 44.

    Adolph AJ, Smith TE, Adolph J Benign multicystic mesothelioma: a case report. J Obstet Gynaecol Can 2002;24:246–247

    PubMed  CAS  Google Scholar 

  45. 45.

    Hanukoglu A, Gewurtz G, Zaidel L, et al. Benign cystic mesothelioma of the peritoneum: the occurrence of an adult entity in a child. Med Pediatr Oncol 1992;20:169–171

    PubMed  CAS  Google Scholar 

  46. 46.

    Yan TD, Haveric N, Carmignani CP, et al. Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy. Cancer 2005;103:839–849

    Article  PubMed  Google Scholar 

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Correspondence to Jon Arne Søreide MD, PhD.

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Søreide, J.A., Søreide, K., Körner, H. et al. Benign Peritoneal Cystic Mesothelioma. World J. Surg. 30, 560–566 (2006). https://doi.org/10.1007/s00268-005-0639-z

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Keywords

  • Malignant Mesothelioma
  • Pseudomyxoma Peritonei
  • Peritoneal Mesothelioma
  • Adenomatoid Tumor
  • Peritoneal Inclusion Cyst