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Correlations between Vitamin D Status and Biochemical/Clinical and Pathological Parameters in Primary Hyperparathyroidism

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Abstract

Background

To determine the prevalence of vitamin D deficiency and the effects of vitamin D status on parathyroid adenoma weight, clinical and biochemical indices in patients with primary hyperparathyroidism (pHPT) were studied.

Methods

Eighty patients with pHPT who underwent surgical treatment and in whom the presence of parathyroid adenoma were confirmed histopathologically were studied retrospectively from recorded data files. Patients were divided into three groups: patients with 25-hydroxyvitamin D (25-OHD) concentrations < 15 ng/ml (group 1, n = 44), patients with 25-OHD concentrations > 15–25 ng/ml (group 2, n = 9), and patients with 25-OHD concentrations > 26 ng/ml (group 3, n = 27). Serum calcium, phosphate, alkaline phosphatase, creatinine, and albumin levels and urinary calcium excretion were determined by auto-analyzer. Plasma 25-OHD and parathyroid hormone (PTH) levels were determined by immunoradiometric assay using commercially available kits.

Results

No statistically significant differences were observed with respect to serum calcium, phosphorus, albumin, and creatinine concentrations between these groups. Serum PTH, alkaline phosphatase concentrations, urinary calcium excretion, parathyroid adenoma weight, and postoperative sixth month PTH concentrations were significantly higher in group 1 patients than in group 2 and group 3 patients. Significant correlations were observed between parathyroid adenoma weight and serum 25-OHD concentrations (r = −0.348, P = 0.020); parathyroid adenoma weight and urinary calcium excretion (r = 0.348, P = 0.021). Multiple regression analysis revealed that parathyroid adenoma weight, serum 25-OHD, and preoperative PTH concentrations correlated independently and significantly with postoperative sixth month PTH concentrations.

Conclusions

Vitamin D deficiency leads to more severe bone disease, increased parathyroid tumor growth, and delayed postoperative recovery of parathyroid function in patients with primary hyperparathyroidism.

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Authors and Affiliations

  1. Department of Endocrinology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, CAPA, 34390, Turkey

    Neşe Özbey

  2. Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, CAPA, 34390, Turkey

    Yeşim Erbil, Selçuk Özarmağan, Umut Barbaros MD & Alp Bozbora

  3. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, CAPA, 34390, Turkey

    Evin Ademoğlu

Authors
  1. Neşe Özbey
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  2. Yeşim Erbil
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  3. Evin Ademoğlu
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  4. Selçuk Özarmağan
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  5. Umut Barbaros MD
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  6. Alp Bozbora
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Correspondence to Yeşim Erbil.

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Özbey, N., Erbil, Y., Ademoğlu, E. et al. Correlations between Vitamin D Status and Biochemical/Clinical and Pathological Parameters in Primary Hyperparathyroidism. World J. Surg. 30, 321–326 (2006). https://doi.org/10.1007/s00268-005-0239-y

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  • DOI: https://doi.org/10.1007/s00268-005-0239-y

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