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Serum Hyaluronate Level for Predicting Subclinical Liver Dysfunction after Hepatectomy

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Abstract

The serum hyaluronate (HA) level reflects sinusoidal endothelial cell function correlated with liver function. We have reviewed multiple liver function indicators from 37 patients who underwent hepatectomy for various liver diseases. The serum HA level was well correlated with the indocyanine green retention rate at 15 minutes (ICGR15), lectin-cholesterol (LCAT), hepatocyte growth factor (HGF), liver uptake ratio of technetium-99m galactosyl human serum albumin (99mTc-GSA) at 15 minutes (HH15), prealbumin, and hepatic uptake ratio of 99mTc-GSA at 15 minutes (LHL15). In addition, the model for end-stage liver disease (MELD) score at 7 days after operation was well correlated with serum HA, ICGR15, HH15, and LHL15. In patients who showed serum an HA level of = 100 ng/ml before hepatectomy, the MELD score had significantly deteriorated by 7 days after hepatectomy. Of the 20 patients who showed a serum HA level < 100 ng/ml before hepatectomy, 11 had high serum HA after hepatectomy. The bilirubin level 7 days after operation in this group was much higher than that for patients who maintained a serum HA level < 100 ng/ml after hepatectomy. In addition, the serum HGF level before hepatectomy in this group was significantly lower. We concluded that the serum HA level is a reliable indicator when evaluating liver function and predicting liver dysfunction after hepatectomy. Furthermore, patients with a significantly low HGF level who have a normal HA level are susceptible to liver dysfunction after hepatectomy.

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References

  1. T Katsuramaki K Fujimori T Furuhata et al. (2003) ArticleTitlePreoperative estimation of risk in hepatectomy using technetium-99m-galactosyl human serum albumin receptor amount by nonlinear 3-compartment model Hepatogastroenterology 50 174–177 Occurrence Handle12630017

    PubMed  Google Scholar 

  2. CT McGary RH Raja PH Weigel (1989) ArticleTitleEndocytosis of hyaluronic acid by rat liver endothelial cells: evidence for receptor recycling Biochem. J. 257 875–884 Occurrence Handle1:CAS:528:DyaL1MXpt1GmtQ%3D%3D Occurrence Handle2930491

    CAS  PubMed  Google Scholar 

  3. S Tamaki T Ueno T Torimura et al. (1996) ArticleTitleEvaluation of hyaluronic acid binding ability of hepatic sinusoidal endothelial cells in rats with liver cirrhosis Gastroenterology 111 1049–1057 Occurrence Handle1:CAS:528:DyaK28XmsFCrsrs%3D Occurrence Handle8831601

    CAS  PubMed  Google Scholar 

  4. A Engstrom-Laurent L Loof A Nyberg et al. (1985) ArticleTitleIncreased serum levels of hyaluronate in liver disease Hepatology 5 638–642 Occurrence Handle1:STN:280:BiqB2MbksVc%3D Occurrence Handle4018736

    CAS  PubMed  Google Scholar 

  5. S Yachida H Wakabayashi Y Kokudo et al. (2000) ArticleTitleMeasurement of serum hyaluronate as a predictor of human liver failure after major hepatectomy World J. Surg. 24 359–364 Occurrence Handle10.1007/s002689910057 Occurrence Handle1:STN:280:DC%2BD3c7is1Cgtw%3D%3D Occurrence Handle10658073

    Article  CAS  PubMed  Google Scholar 

  6. BC Das S Isaji Y Kawarada (2001) ArticleTitleAnalysis of 100 consecutive hepatectomies: risk factors in patients with liver cirrhosis or obstructive jaundice World J. Surg. 25 266–273 Occurrence Handle10.1007/s002680020059 Occurrence Handle1:STN:280:DC%2BD3M3ktFOhtw%3D%3D Occurrence Handle11343174

    Article  CAS  PubMed  Google Scholar 

  7. GK Michalopoulos MC DeFrances (1997) ArticleTitleLiver regeneration Science 276 60–66 Occurrence Handle10.1126/science.276.5309.60 Occurrence Handle1:CAS:528:DyaK2sXitlyqt78%3D Occurrence Handle9082986

    Article  CAS  PubMed  Google Scholar 

  8. T Mizuguchi Y Kamohara T Hui et al. (2001) ArticleTitleRegulation of c-met expression in rats with acute hepatic failure J. Surg. Res. 99 385–396 Occurrence Handle10.1006/jsre.2001.6216 Occurrence Handle1:CAS:528:DC%2BD3MXlsVSjt7g%3D Occurrence Handle11469916

    Article  CAS  PubMed  Google Scholar 

  9. Y Matsuda K Matsumoto A Yamada et al. (1997) ArticleTitlePreventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis Hepatology 26 81–89 Occurrence Handle10.1016/S0168-8278(97)80500-4 Occurrence Handle1:CAS:528:DyaK2sXkslagtL0%3D Occurrence Handle9214455

    Article  CAS  PubMed  Google Scholar 

  10. J Okano G Shiota H Kawasaki (1997) ArticleTitleProtective action of hepatocyte growth factor for acute liver injury caused by d-galactosamine in transgenic mice Hepatology 26 1241–1249 Occurrence Handle1:CAS:528:DyaK2sXntl2jt7o%3D Occurrence Handle9362368

    CAS  PubMed  Google Scholar 

  11. G Shiota J Okano H Kawasaki et al. (1995) ArticleTitleSerum hepatocyte growth factor levels in liver diseases: clinical implications Hepatology 21 106–112 Occurrence Handle10.1016/0270-9139(95)90416-6 Occurrence Handle1:STN:280:ByqC3cvnsVM%3D Occurrence Handle7806142

    Article  CAS  PubMed  Google Scholar 

  12. P Schirmacher A Geerts A Pietrangelo et al. (1992) ArticleTitleHepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells Hepatology 15 5–11 Occurrence Handle1:CAS:528:DyaK38Xht1Ggt7s%3D Occurrence Handle1530788

    CAS  PubMed  Google Scholar 

  13. S Noji K Tashiro E Koyama et al. (1990) ArticleTitleExpression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization Biochem. Biophys. Res. Commun. 173 42–47 Occurrence Handle1:CAS:528:DyaK3MXktVartQ%3D%3D Occurrence Handle2147853

    CAS  PubMed  Google Scholar 

  14. JJ Maher (1993) ArticleTitleCell-specific expression of hepatocyte growth factor in liver: upregulation in sinusoidal endothelial cells after carbon tetrachloride J. Clin. Invest. 91 2244–2252 Occurrence Handle1:CAS:528:DyaK3sXkt1Wit7o%3D Occurrence Handle7683700

    CAS  PubMed  Google Scholar 

  15. M Kudo A Todo K Ikekubo et al. (1993) ArticleTitleQuantitative assessment of hepatocellular function through in vivo radioreceptor imaging with technetium 99m galactosyl human serum albumin Hepatology 17 814–819 Occurrence Handle10.1016/0270-9139(93)90157-I Occurrence Handle1:CAS:528:DyaK3sXks1KksLc%3D Occurrence Handle8491449

    Article  CAS  PubMed  Google Scholar 

  16. PS Kamath RH Wiesner M Malinchoc et al. (2001) ArticleTitleA model to predict survival in patients with end-stage liver disease Hepatology 33 464–470 Occurrence Handle10.1053/jhep.2001.22172 Occurrence Handle1:STN:280:DC%2BD3M7kvVOqug%3D%3D Occurrence Handle11172350

    Article  CAS  PubMed  Google Scholar 

  17. RN Pugh IM Murray-Lyon JL Dawson et al. (1973) ArticleTitleTransection of the oesophagus for bleeding oesophageal varices Br. J. Surg. 60 646–649 Occurrence Handle1:STN:280:CSyB3svhvFU%3D Occurrence Handle4541913

    CAS  PubMed  Google Scholar 

  18. SD Ryder (2003) ArticleTitleGuidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults Gut 52 iii1–iii8 Occurrence Handle10.1136/gut.52.suppl_3.iii1 Occurrence Handle12692148

    Article  PubMed  Google Scholar 

  19. B Angermayr M Cejna F Karnel et al. (2003) ArticleTitleChild-Pugh versus MELD score in predicting survival in patients undergoing transjugular intrahepatic portosystemic shunt Gut 52 879–885 Occurrence Handle10.1136/gut.52.6.879 Occurrence Handle1:STN:280:DC%2BD3s3lvFWjsg%3D%3D Occurrence Handle12740346

    Article  CAS  PubMed  Google Scholar 

  20. B Smedsrod H Pertoft S Eriksson et al. (1984) ArticleTitleStudies in vitro on the uptake and degradation of sodium hyaluronate in rat liver endothelial cells Biochem. J. 223 617–626 Occurrence Handle1:STN:280:BiqD2s3gt1E%3D Occurrence Handle6508733

    CAS  PubMed  Google Scholar 

  21. AM Gressner S Schafer (1989) ArticleTitleComparison of sulphated glycosaminoglycan and hyaluronate synthesis and secretion in cultured hepatocytes, fat storing cells, and Kupffer cells J. Clin. Chem. Clin. Biochem. 27 141–149 Occurrence Handle1:CAS:528:DyaL1MXhvV2ru7o%3D Occurrence Handle2708943

    CAS  PubMed  Google Scholar 

  22. JR Fraser TC Laurent A Engstrom-Laurent et al. (1984) ArticleTitleElimination of hyaluronic acid from the blood stream in the human Clin. Exp. Pharmacol. Physiol. 11 17–25 Occurrence Handle1:CAS:528:DyaL2cXhsFSlsrk%3D Occurrence Handle6713733

    CAS  PubMed  Google Scholar 

  23. H Shimizu W He P Guo et al. (1994) ArticleTitleSerum hyaluronate in the assessment of liver endothelial cell function after orthotopic liver transplantation in the rat Hepatology 20 1323–1329 Occurrence Handle10.1016/0270-9139(94)90775-7 Occurrence Handle1:CAS:528:DyaK2MXitFWks7s%3D Occurrence Handle7927268

    Article  CAS  PubMed  Google Scholar 

  24. L Paimela A Heiskanen P Kurki et al. (1991) ArticleTitleSerum hyaluronate level as a predictor of radiologic progression in early rheumatoid arthritis Arthritis Rheum. 34 815–821 Occurrence Handle1:STN:280:By6B1c3ot1Q%3D Occurrence Handle2059229

    CAS  PubMed  Google Scholar 

  25. A Engstrom-Laurent N Feltelius R Hallgren et al. (1985) ArticleTitleRaised serum hyaluronate levels in scleroderma: an effect of growth factor induced activation of connective tissue cells? Ann. Rheum. Dis. 44 614–620 Occurrence Handle1:STN:280:BiqA3crptFI%3D Occurrence Handle3876080

    CAS  PubMed  Google Scholar 

  26. RK Reed UB Laurent JR Fraser et al. (1990) ArticleTitleRemoval rate of [3H]hyaluronan injected subcutaneously in rabbits Am. J. Physiol. 259 H532–H535 Occurrence Handle1:CAS:528:DyaK3cXlsV2gtLY%3D Occurrence Handle2386226

    CAS  PubMed  Google Scholar 

  27. N Fausto (2000) ArticleTitleLiver regeneration J. Hepatol. 32 19–31 Occurrence Handle10.1016/S0168-8278(00)80412-2 Occurrence Handle1:CAS:528:DC%2BD3cXisFOns7k%3D

    Article  CAS  Google Scholar 

  28. Y Yamashita A Shiota N Fujise et al. (1998) ArticleTitleEffects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis J. Vet. Med. Sci. 60 359–360 Occurrence Handle10.1292/jvms.60.359 Occurrence Handle1:STN:280:DyaK1c3itFGmtQ%3D%3D Occurrence Handle9560786

    Article  CAS  PubMed  Google Scholar 

  29. A Bardelli P Longati D Albero et al. (1996) ArticleTitleHGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death EMBO J. 15 6205–6212 Occurrence Handle1:CAS:528:DyaK28XnsFOju7o%3D Occurrence Handle8947043

    CAS  PubMed  Google Scholar 

  30. T Kaido S Yamaoka S Seto et al. (1997) ArticleTitleContinuous hepatocyte growth factor supply prevents lipopolysaccharide-induced liver injury in rats FEBS Lett. 411 378–382 Occurrence Handle10.1016/S0014-5793(97)00744-8 Occurrence Handle1:CAS:528:DyaK2sXktlGjsb4%3D Occurrence Handle9271240

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank Mr. Kim Barrymore for his help in preparing this manuscript. Part of this study was supported by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture, Japan (15790696 to T.M. and 12470265 and 13557107 to K.H. Part of this study was also supported by funds from the Sumitomo Trust (to T.M.).

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Correspondence to Toru Mizuguchi M.D., Ph.D..

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Mizuguchi, T., Katsuramaki, T., Nobuoka, T. et al. Serum Hyaluronate Level for Predicting Subclinical Liver Dysfunction after Hepatectomy. World J. Surg. 28, 971–976 (2004). https://doi.org/10.1007/s00268-004-7389-1

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